FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292247275> ?p ?o ?g. }

• W4292247275 abstract "Florida Native is a heritage sheep breed in the United States and expresses superior ability to regulate gastrointestinal nematodes. The objective of the present study was to investigate the importance of copy number variants (CNVs) on resistance to natural Haemonchus contortus infections. A total of 300 Florida Native sheep were evaluated. Phenotypic records included fecal egg count (FEC, eggs/gram), FAMACHA© score, percentage cell volume (PCV, %), body condition score (BCS) and average daily gain (ADG, kg). Sheep were genotyped using the GGP Ovine 50K single nucleotide polymorphism (SNP) chip. Log ratios from 45.2 k SNP markers spanning the entire genome were utilized for CNV detection. After quality control, 261 animals with CNVs and phenotypic records were used for the association testing. Association tests were carried out using correlation-trend test and principal component analysis correction to identify CNVs associated with FEC, FAMACHA©, PCV, BCS and ADG. Significant CNVs were detected when their adjusted p-value was <.05 after FDR correction. A total of 8124 CNVs were identified, which gave 246 non-overlapping CNVs. Fourteen CNVs were significantly associated with FEC and PCV. CNVs associated with FEC overlapped 14 Quantitative Trait Locus previously associated with H. contortus resistance. Our study demonstrated for the first time that CNVs could be potentially involved with parasite resistance in Florida Native sheep. Immune-related genes such as CCL1, CCL2, CCL8, CCL11, NOS2, TNF, CSF3 and STAT3 genes could play an important role for controlling H. contortus resistance. These genes could be potentially utilized as candidate markers for selection of parasite resistance in this breed." @default.
• W4292247275 created "2022-08-19" @default.
• W4292247275 creator A5028365790 @default.
• W4292247275 creator A5050789062 @default.
• W4292247275 creator A5085265418 @default.
• W4292247275 creator A5090146164 @default.
• W4292247275 date "2022-09-07" @default.
• W4292247275 modified "2023-10-12" @default.
• W4292247275 title "Copy number variant‐based genome wide association study reveals immune‐related genes associated with parasite resistance in a heritage sheep breed from the United States" @default.
• W4292247275 cites W1412756978 @default.
• W4292247275 cites W1527743177 @default.
• W4292247275 cites W1583774698 @default.
• W4292247275 cites W1963823134 @default.
• W4292247275 cites W1965778925 @default.
• W4292247275 cites W1973645863 @default.
• W4292247275 cites W1992396524 @default.
• W4292247275 cites W2003610501 @default.
• W4292247275 cites W2009378188 @default.
• W4292247275 cites W2011505235 @default.
• W4292247275 cites W2013164930 @default.
• W4292247275 cites W2014606320 @default.
• W4292247275 cites W2014647718 @default.
• W4292247275 cites W2015894758 @default.
• W4292247275 cites W2016952830 @default.
• W4292247275 cites W2021990840 @default.
• W4292247275 cites W2028005736 @default.
• W4292247275 cites W2032141740 @default.
• W4292247275 cites W2036597538 @default.
• W4292247275 cites W2037546635 @default.
• W4292247275 cites W2043165579 @default.
• W4292247275 cites W2048809938 @default.
• W4292247275 cites W2049117580 @default.
• W4292247275 cites W2054069038 @default.
• W4292247275 cites W2073933067 @default.
• W4292247275 cites W2077560413 @default.
• W4292247275 cites W2093172276 @default.
• W4292247275 cites W2094174059 @default.
• W4292247275 cites W2149221426 @default.
• W4292247275 cites W2154054213 @default.
• W4292247275 cites W2158221283 @default.
• W4292247275 cites W2162927194 @default.
• W4292247275 cites W2236270374 @default.
• W4292247275 cites W2264759678 @default.
• W4292247275 cites W2483177305 @default.
• W4292247275 cites W2552485160 @default.
• W4292247275 cites W2593757611 @default.
• W4292247275 cites W2621737315 @default.
• W4292247275 cites W2754505756 @default.
• W4292247275 cites W2898567584 @default.
• W4292247275 cites W2942034784 @default.
• W4292247275 cites W2973724609 @default.
• W4292247275 cites W2980648085 @default.
• W4292247275 cites W3084284006 @default.
• W4292247275 cites W3126672577 @default.
• W4292247275 cites W3161762821 @default.
• W4292247275 cites W4292247275 @default.
• W4292247275 cites W4298858 @default.
• W4292247275 doi "https://doi.org/10.1111/pim.12943" @default.
• W4292247275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36071651" @default.
• W4292247275 hasPublicationYear "2022" @default.
• W4292247275 type Work @default.
• W4292247275 citedByCount "3" @default.
• W4292247275 countsByYear W42922472752022 @default.
• W4292247275 countsByYear W42922472752023 @default.
• W4292247275 crossrefType "journal-article" @default.
• W4292247275 hasAuthorship W4292247275A5028365790 @default.
• W4292247275 hasAuthorship W4292247275A5050789062 @default.
• W4292247275 hasAuthorship W4292247275A5085265418 @default.
• W4292247275 hasAuthorship W4292247275A5090146164 @default.
• W4292247275 hasBestOaLocation W42922472751 @default.
• W4292247275 hasConcept C104317684 @default.
• W4292247275 hasConcept C106208931 @default.
• W4292247275 hasConcept C120821319 @default.
• W4292247275 hasConcept C122060243 @default.
• W4292247275 hasConcept C135763542 @default.
• W4292247275 hasConcept C139275648 @default.
• W4292247275 hasConcept C141231307 @default.
• W4292247275 hasConcept C153209595 @default.
• W4292247275 hasConcept C165901193 @default.
• W4292247275 hasConcept C186413461 @default.
• W4292247275 hasConcept C203014093 @default.
• W4292247275 hasConcept C2776482104 @default.
• W4292247275 hasConcept C2779825395 @default.
• W4292247275 hasConcept C54355233 @default.
• W4292247275 hasConcept C69991583 @default.
• W4292247275 hasConcept C81941488 @default.
• W4292247275 hasConcept C84597430 @default.
• W4292247275 hasConcept C86803240 @default.
• W4292247275 hasConcept C9287583 @default.
• W4292247275 hasConceptScore W4292247275C104317684 @default.
• W4292247275 hasConceptScore W4292247275C106208931 @default.
• W4292247275 hasConceptScore W4292247275C120821319 @default.
• W4292247275 hasConceptScore W4292247275C122060243 @default.
• W4292247275 hasConceptScore W4292247275C135763542 @default.
• W4292247275 hasConceptScore W4292247275C139275648 @default.
• W4292247275 hasConceptScore W4292247275C141231307 @default.
• W4292247275 hasConceptScore W4292247275C153209595 @default.
• W4292247275 hasConceptScore W4292247275C165901193 @default.
• W4292247275 hasConceptScore W4292247275C186413461 @default.
• W4292247275 hasConceptScore W4292247275C203014093 @default.

• next