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- W4292247496 endingPage "9317" @default.
- W4292247496 startingPage "9317" @default.
- W4292247496 abstract "Salivary gland tumors represent a serious medical problem and new tools for differential diagnosis and patient monitoring are needed. Here, we present data and discuss the potential of molecular chaperones as biomarkers and therapeutic targets, focusing on Hsp10 and Hsp90. The salivary glands are key physiological elements but, unfortunately, the information and the means available for the management of their pathologies, including cancer, are scarce. Progress in the study of carcinogenesis has occurred on various fronts lately, one of which has been the identification of the chaperone system (CS) as a physiological system with presence in all cells and tissues (including the salivary glands) that plays a role in tumor-cell biology. The chief components of the CS are the molecular chaperones, some of which belong to families of evolutionarily related molecules named heat shock protein (Hsp). We are quantifying and mapping these molecular chaperones in salivary glands to determine their possible role in the carcinogenetic mechanisms in these glands and to assess their potential as diagnostic biomarkers and therapeutic targets. Here, we report recent findings on Hsp10 and Hsp90 and show that the quantitative and topographic patterns of tissue Hsp90 are distinctive of malignant tumors and differentiate benign from malignant lesions. The Hsp90 results show a correlation between quantity of chaperone and tumor progression, which in turn calls for negative chaperonotherapy, namely, elimination/inhibition of the chaperone to stop the tumor. We found that in vitro, the Hsp90 inhibitor Ganetespib is cytotoxic for the salivary gland UM-HACC-2A cell line. The drug, by interfering with the pro-survival NF-κB pathway, hampers cellular proliferation and migration, and favors apoptosis, and can, therefore, be considered a suitable candidate for future experimentation to develop a treatment for salivary gland tumors." @default.
- W4292247496 created "2022-08-19" @default.
- W4292247496 creator A5014042288 @default.
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- W4292247496 creator A5075254959 @default.
- W4292247496 creator A5087378104 @default.
- W4292247496 date "2022-08-18" @default.
- W4292247496 modified "2023-09-26" @default.
- W4292247496 title "The Chaperone System in Salivary Glands: Hsp90 Prospects for Differential Diagnosis and Treatment of Malignant Tumors" @default.
- W4292247496 cites W1525657614 @default.
- W4292247496 cites W1820331374 @default.
- W4292247496 cites W1892753805 @default.
- W4292247496 cites W1963506820 @default.
- W4292247496 cites W1969768379 @default.
- W4292247496 cites W1975131304 @default.
- W4292247496 cites W1979556835 @default.
- W4292247496 cites W1982383741 @default.
- W4292247496 cites W1985163885 @default.
- W4292247496 cites W1991196199 @default.
- W4292247496 cites W1991241647 @default.
- W4292247496 cites W1998055009 @default.
- W4292247496 cites W2003603336 @default.
- W4292247496 cites W2005621869 @default.
- W4292247496 cites W2011116859 @default.
- W4292247496 cites W2014537095 @default.
- W4292247496 cites W2014881369 @default.
- W4292247496 cites W2021267847 @default.
- W4292247496 cites W2021777937 @default.
- W4292247496 cites W2022234086 @default.
- W4292247496 cites W2026888844 @default.
- W4292247496 cites W2028383952 @default.
- W4292247496 cites W2030982690 @default.
- W4292247496 cites W2053253397 @default.
- W4292247496 cites W2060148257 @default.
- W4292247496 cites W2072402454 @default.
- W4292247496 cites W2073886258 @default.
- W4292247496 cites W2074516633 @default.
- W4292247496 cites W2074805964 @default.
- W4292247496 cites W2089400513 @default.
- W4292247496 cites W2089776151 @default.
- W4292247496 cites W2098224915 @default.
- W4292247496 cites W2099031921 @default.
- W4292247496 cites W2100370559 @default.
- W4292247496 cites W2116082448 @default.
- W4292247496 cites W2118605659 @default.
- W4292247496 cites W2118851638 @default.
- W4292247496 cites W2122216968 @default.
- W4292247496 cites W2129302331 @default.
- W4292247496 cites W2131822545 @default.
- W4292247496 cites W2141956720 @default.
- W4292247496 cites W2145972625 @default.
- W4292247496 cites W2158797202 @default.
- W4292247496 cites W2163188200 @default.
- W4292247496 cites W2163295338 @default.
- W4292247496 cites W2167862457 @default.
- W4292247496 cites W2169705405 @default.
- W4292247496 cites W2240905806 @default.
- W4292247496 cites W2256726316 @default.
- W4292247496 cites W2256952545 @default.
- W4292247496 cites W2280878239 @default.
- W4292247496 cites W2300422020 @default.
- W4292247496 cites W2308276320 @default.
- W4292247496 cites W2324910620 @default.
- W4292247496 cites W2418233915 @default.
- W4292247496 cites W2443819849 @default.
- W4292247496 cites W2465729507 @default.
- W4292247496 cites W2480237799 @default.
- W4292247496 cites W2500846231 @default.
- W4292247496 cites W2550521968 @default.
- W4292247496 cites W2560070304 @default.
- W4292247496 cites W2560997559 @default.
- W4292247496 cites W2570618306 @default.
- W4292247496 cites W2575363022 @default.
- W4292247496 cites W2581821348 @default.
- W4292247496 cites W2587457642 @default.
- W4292247496 cites W2588881160 @default.
- W4292247496 cites W2591253403 @default.
- W4292247496 cites W2593119424 @default.
- W4292247496 cites W2606526816 @default.
- W4292247496 cites W2733316209 @default.
- W4292247496 cites W2736124285 @default.
- W4292247496 cites W2780860952 @default.
- W4292247496 cites W2794088236 @default.
- W4292247496 cites W2794335286 @default.
- W4292247496 cites W2798140734 @default.
- W4292247496 cites W2799880735 @default.
- W4292247496 cites W2804173788 @default.
- W4292247496 cites W2889331509 @default.
- W4292247496 cites W2889502232 @default.
- W4292247496 cites W2896419620 @default.
- W4292247496 cites W2909886854 @default.
- W4292247496 cites W2921217908 @default.
- W4292247496 cites W2934765358 @default.
- W4292247496 cites W2937714804 @default.