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- W4292248049 startingPage "9283" @default.
- W4292248049 abstract "The aim of this in vitro study was to investigate the commitment and behavior of dental pulp stem cells (DPSCs) seeded onto two different grafting materials, human dentin particulate (DP) and deproteinized bovine bone matrix (BG), with those cultured in the absence of supplements. Gene expression analyses along with epigenetic and morphological tests were carried out to examine odontogenic and osteogenic differentiation and cell proliferation. Compressive testing of the grafting materials seeded with DPSCs was performed as well. DPSC differentiation into odontoblast-like cells was identified from the upregulation of odontogenic markers (DSPP and MSX) and osteogenic markers (RUNX2, alkaline phosphatase, osteonectin, osteocalcin, collagen type I, bmp2, smad5/8). Epigenetic tests confirmed the presence of miRNAs involved in odontogenic or osteogenic commitment of DPSCs cultured for up to 21 days on DP. Compressive strength values obtained from extracellular matrix (ECM) synthesized by DPSCs showed a trend of being higher when seeded onto DP than onto BG. High expression of VEGF factor, which is related to angiogenesis, and of dentin sialoprotein was observed only in the presence of DP. Morphological analyses confirmed the typical phenotype of adult odontoblasts. In conclusion, the odontogenic and osteogenic commitment of DPSCs and their respective functions can be achieved on DP, which enables exceptional dentin and bone regeneration." @default.
- W4292248049 created "2022-08-19" @default.
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- W4292248049 date "2022-08-18" @default.
- W4292248049 modified "2023-09-25" @default.
- W4292248049 title "Dentin Particulate for Bone Regeneration: An In Vitro Study" @default.
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- W4292248049 doi "https://doi.org/10.3390/ijms23169283" @default.
- W4292248049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36012558" @default.
- W4292248049 hasPublicationYear "2022" @default.
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