Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292259367> ?p ?o ?g. }
- W4292259367 endingPage "104198" @default.
- W4292259367 startingPage "104198" @default.
- W4292259367 abstract "As a ATP-binding cassette (ABC) transporter the OppA receptor plays key roles in protecting the host organism and transporting nutrients across the intestine by the oligopeptide transporter from symbiotic bacteria and directs maturation of the host immune system. Among lactic acid bacteria, Bifidobacterium longum KACC91563, isolated from fecal samples of healthy Korean neonates, has the capability to alleviate food allergy effects. Operating as a peptide importer, the extracellular OppA receptor from gram-positive B. longum KACC91563 translocates nutrients, specifically peptides, from the outside environment of the intestinal tract to the inside of symbiotic cells. In the present study we attempt to explicate the relationship between the substrate’s specificity from the OppA importer and the probiotic effects of B. longum KACC91563 in the host intestine. It was first identified in this study the specialized structure–function relationship from the OppA importer of B. longum KACC91563 with its structural and functional determinants. This could provide insights into substrate specificity of unique immunological properties and a key switch for the substrate’s metabolism to reprogramming immune responses in the host intestine by structure-based molecular modeling. The probiotic effects of oligopeptide substrate (such as a proline-rich peptide containing at least one branched residue of leucine, isoleucine, and valine) and its metabolism for the OppA from B. longum KACC91563 are attributed to enhancement of the epithelial barrier by several different strain specific pathways to prevent the strong adhesion of pathogens." @default.
- W4292259367 created "2022-08-19" @default.
- W4292259367 creator A5021858665 @default.
- W4292259367 creator A5043731787 @default.
- W4292259367 creator A5058474336 @default.
- W4292259367 creator A5066209020 @default.
- W4292259367 date "2022-11-01" @default.
- W4292259367 modified "2023-09-27" @default.
- W4292259367 title "Identifying ligand-binding specificity of the oligopeptide receptor OppA from Bifidobacterium longum KACC91563 by structure-based molecular modeling" @default.
- W4292259367 cites W1482516139 @default.
- W4292259367 cites W1747678681 @default.
- W4292259367 cites W1833804620 @default.
- W4292259367 cites W1923589852 @default.
- W4292259367 cites W1967754278 @default.
- W4292259367 cites W1972599527 @default.
- W4292259367 cites W1975304761 @default.
- W4292259367 cites W1981490865 @default.
- W4292259367 cites W1983311737 @default.
- W4292259367 cites W1988988021 @default.
- W4292259367 cites W1989228404 @default.
- W4292259367 cites W1990308099 @default.
- W4292259367 cites W1992192767 @default.
- W4292259367 cites W1993023349 @default.
- W4292259367 cites W1993358333 @default.
- W4292259367 cites W1993689973 @default.
- W4292259367 cites W1999613945 @default.
- W4292259367 cites W2006304581 @default.
- W4292259367 cites W2011346711 @default.
- W4292259367 cites W2016888450 @default.
- W4292259367 cites W2024381234 @default.
- W4292259367 cites W2026720253 @default.
- W4292259367 cites W2030423316 @default.
- W4292259367 cites W2033294574 @default.
- W4292259367 cites W2035126854 @default.
- W4292259367 cites W2041338197 @default.
- W4292259367 cites W2045119680 @default.
- W4292259367 cites W2050523255 @default.
- W4292259367 cites W2053494703 @default.
- W4292259367 cites W2058583788 @default.
- W4292259367 cites W2060872117 @default.
- W4292259367 cites W2061816351 @default.
- W4292259367 cites W2063769219 @default.
- W4292259367 cites W2066386335 @default.
- W4292259367 cites W2073489889 @default.
- W4292259367 cites W2074986801 @default.
- W4292259367 cites W2077553363 @default.
- W4292259367 cites W2087828356 @default.
- W4292259367 cites W2099471962 @default.
- W4292259367 cites W2102993309 @default.
- W4292259367 cites W2103726835 @default.
- W4292259367 cites W2109283416 @default.
- W4292259367 cites W2110576018 @default.
- W4292259367 cites W2116128404 @default.
- W4292259367 cites W2119508143 @default.
- W4292259367 cites W2120205420 @default.
- W4292259367 cites W2126383924 @default.
- W4292259367 cites W2132043383 @default.
- W4292259367 cites W2135416344 @default.
- W4292259367 cites W2141906439 @default.
- W4292259367 cites W2143099619 @default.
- W4292259367 cites W2146450264 @default.
- W4292259367 cites W2146559520 @default.
- W4292259367 cites W2147113485 @default.
- W4292259367 cites W2147776166 @default.
- W4292259367 cites W2156053468 @default.
- W4292259367 cites W2156522373 @default.
- W4292259367 cites W2158675123 @default.
- W4292259367 cites W2164917731 @default.
- W4292259367 cites W2166173217 @default.
- W4292259367 cites W2169629955 @default.
- W4292259367 cites W2169964279 @default.
- W4292259367 cites W2329589324 @default.
- W4292259367 cites W2339113488 @default.
- W4292259367 cites W2462837143 @default.
- W4292259367 cites W2464484550 @default.
- W4292259367 cites W2465559785 @default.
- W4292259367 cites W2511242571 @default.
- W4292259367 cites W2513043545 @default.
- W4292259367 cites W2582679467 @default.
- W4292259367 cites W2621339753 @default.
- W4292259367 cites W2789850489 @default.
- W4292259367 cites W2790486637 @default.
- W4292259367 cites W2806079229 @default.
- W4292259367 cites W2806231480 @default.
- W4292259367 cites W2807728333 @default.
- W4292259367 cites W2892666215 @default.
- W4292259367 cites W2904833041 @default.
- W4292259367 cites W2988480199 @default.
- W4292259367 cites W2996596598 @default.
- W4292259367 cites W3004016955 @default.
- W4292259367 cites W3014477180 @default.
- W4292259367 cites W3030574348 @default.
- W4292259367 cites W3110492090 @default.
- W4292259367 cites W4211107352 @default.
- W4292259367 cites W4230128459 @default.
- W4292259367 cites W4250614167 @default.
- W4292259367 doi "https://doi.org/10.1016/j.arabjc.2022.104198" @default.
- W4292259367 hasPublicationYear "2022" @default.