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- W4292261036 abstract "B cell lymphoma therapy has been transformed by CD19-targeting cellular therapeutics that induce high clinical response rates and impressive remissions in relapsed and refractory patients. However, approximately half of all patients who respond to CD19-directed cell therapy relapse, the majority within 6 months. One characteristic of relapse is loss or reduction of CD19 expression on malignant B cells. We designed a unique therapeutic to prevent and reverse relapses due to lost or reduced CD19 expression. This novel biologic, a CAR T Engager, binds CD20 and displays the CD19 extracellular domain. This approach increases the apparent CD19 antigen density on CD19-positive/CD20-positive lymphoma cells, and prevents antigen-loss induced relapse, as CD19 bound to CD20 remains present on the cell surface. We demonstrate that this novel therapeutic prevents and reverses lymphoma relapse in vitro and prevents CD19-negative lymphoma growth and relapse in vivo." @default.
- W4292261036 created "2022-08-19" @default.
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- W4292261036 date "2022-08-17" @default.
- W4292261036 modified "2023-09-26" @default.
- W4292261036 title "CAR-T Engager proteins optimize anti-CD19 CAR-T cell therapies for lymphoma" @default.
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- W4292261036 doi "https://doi.org/10.1080/2162402x.2022.2111904" @default.
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