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- W4292261103 abstract "Hepatocellular carcinoma (HCC) is still a main health concern around the world, with a rising incidence and high mortality rate. The tumor-promoting components of the tumor microenvironment (TME) play a vital role in the development and metastasis of HCC. TME-targeted therapies have recently drawn increasing interest in the treatment of HCC. However, the short medication retention time in TME limits the efficiency of TME modulating strategies. The nanoparticles can be elaborately designed as needed to specifically target the tumor-promoting components in TME. In this regard, the use of nanomedicine to modulate TME components by delivering drugs with protection and prolonged circulation time in a spatiotemporal manner has shown promising potential. In this review, we briefly introduce the obstacles of TME and highlight the updated information on nanoparticles that modulate these obstacles. Furthermore, the present challenges and future prospects of TME modulating nanomedicines will be briefly discussed." @default.
- W4292261103 created "2022-08-19" @default.
- W4292261103 creator A5044536094 @default.
- W4292261103 creator A5070436601 @default.
- W4292261103 creator A5076518019 @default.
- W4292261103 creator A5080959496 @default.
- W4292261103 date "2022-08-17" @default.
- W4292261103 modified "2023-10-14" @default.
- W4292261103 title "Nanoparticle-Based Therapeutics to Overcome Obstacles in the Tumor Microenvironment of Hepatocellular Carcinoma" @default.
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