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• W4292262959 abstract "Objective Serotonergic psychedelics are re-emerging as potential novel treatments for several psychiatric disorders including major depressive disorder. The Canadian Network for Mood and Anxiety Treatments (CANMAT) convened a task force to review the evidence and provide a consensus recommendation for the clinical use of psychedelic treatments for major depressive disorder. Methods A systematic review was conducted to identify contemporary clinical trials of serotonergic psychedelics for the treatment of major depressive disorder and cancer-related depression. Studies published between January 1990 and July 2021 were identified using combinations of search terms, inspection of bibliographies and review of other psychedelic reviews and consensus statements. The levels of evidence for efficacy were graded according to the Canadian Network for Mood and Anxiety Treatments criteria. Results Only psilocybin and ayahuasca have contemporary clinical trials evaluating antidepressant effects. Two pilot studies showed preliminary positive effects of single-dose ayahuasca for treatment-resistant depression (Level 3 evidence). Small randomized controlled trials of psilocybin combined with psychotherapy showed superiority to waitlist controls and comparable efficacy and safety to an active comparator (escitalopram with supportive psychotherapy) in major depressive disorder, with additional randomized controlled trials showing efficacy specifically in cancer-related depression (Level 3 evidence). There was only one open-label trial of psilocybin in treatment-resistant unipolar depression (Level 4 evidence). Small sample sizes and functional unblinding were major limitations in all studies. Adverse events associated with psychedelics, including psychological (e.g., psychotomimetic effects) and physical (e.g., nausea, emesis and headaches) effects, were generally transient. Conclusions There is currently only low-level evidence to support the efficacy and safety of psychedelics for major depressive disorder. In Canada, as of 2022, psilocybin remains an experimental option that is only available through clinical trials or the special access program. As such, Canadian Network for Mood and Anxiety Treatments considers psilocybin an experimental treatment and recommends its use primarily within clinical trials, or, less commonly, through the special access program in rare, special circumstances." @default.
• W4292262959 created "2022-08-19" @default.
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• W4292262959 date "2022-08-17" @default.
• W4292262959 modified "2023-10-05" @default.
• W4292262959 title "The Canadian Network for Mood and Anxiety Treatments (CANMAT) Task Force Report: Serotonergic Psychedelic Treatments for Major Depressive Disorder" @default.
• W4292262959 cites W1522335173 @default.
• W4292262959 cites W1553790444 @default.
• W4292262959 cites W1985044857 @default.
• W4292262959 cites W1988563049 @default.
• W4292262959 cites W2000909913 @default.
• W4292262959 cites W2026832357 @default.
• W4292262959 cites W2027157675 @default.
• W4292262959 cites W2027585755 @default.
• W4292262959 cites W2039391993 @default.
• W4292262959 cites W2051426845 @default.
• W4292262959 cites W2056232804 @default.
• W4292262959 cites W2059976461 @default.
• W4292262959 cites W2067268774 @default.
• W4292262959 cites W2095852687 @default.
• W4292262959 cites W2096626991 @default.
• W4292262959 cites W2097860992 @default.
• W4292262959 cites W2107899339 @default.
• W4292262959 cites W2108914738 @default.
• W4292262959 cites W2109543774 @default.
• W4292262959 cites W2113099805 @default.
• W4292262959 cites W2118739111 @default.
• W4292262959 cites W2124026487 @default.
• W4292262959 cites W2124291611 @default.
• W4292262959 cites W2129290879 @default.
• W4292262959 cites W2137983723 @default.
• W4292262959 cites W2162010696 @default.
• W4292262959 cites W2165673785 @default.
• W4292262959 cites W2170848267 @default.
• W4292262959 cites W2171340584 @default.
• W4292262959 cites W2342266152 @default.
• W4292262959 cites W2346262441 @default.
• W4292262959 cites W2396675581 @default.
• W4292262959 cites W2417999625 @default.
• W4292262959 cites W2419844652 @default.
• W4292262959 cites W2478017657 @default.
• W4292262959 cites W2485472464 @default.
• W4292262959 cites W2558412547 @default.
• W4292262959 cites W2559739670 @default.
• W4292262959 cites W2589071607 @default.
• W4292262959 cites W2738683289 @default.
• W4292262959 cites W2767530231 @default.
• W4292262959 cites W2768626284 @default.
• W4292262959 cites W2790481213 @default.
• W4292262959 cites W2792027821 @default.
• W4292262959 cites W2885979090 @default.
• W4292262959 cites W2886232664 @default.
• W4292262959 cites W2886249511 @default.
• W4292262959 cites W2895828174 @default.
• W4292262959 cites W2903001666 @default.
• W4292262959 cites W2903601547 @default.
• W4292262959 cites W2952169207 @default.
• W4292262959 cites W2962285119 @default.
• W4292262959 cites W2970757804 @default.
• W4292262959 cites W2981779913 @default.
• W4292262959 cites W2982708806 @default.
• W4292262959 cites W2992322507 @default.
• W4292262959 cites W3000549374 @default.
• W4292262959 cites W3000636165 @default.
• W4292262959 cites W3006905788 @default.
• W4292262959 cites W3010491167 @default.
• W4292262959 cites W3012221112 @default.
• W4292262959 cites W3012354707 @default.
• W4292262959 cites W3024403515 @default.
• W4292262959 cites W3085274948 @default.
• W4292262959 cites W3087462486 @default.
• W4292262959 cites W3090010637 @default.
• W4292262959 cites W3094461574 @default.
• W4292262959 cites W3095307948 @default.
• W4292262959 cites W3096208965 @default.
• W4292262959 cites W3099585958 @default.
• W4292262959 cites W3109908198 @default.
• W4292262959 cites W3112173414 @default.

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