Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292282969> ?p ?o ?g. }
- W4292282969 endingPage "113544" @default.
- W4292282969 startingPage "113544" @default.
- W4292282969 abstract "The human body is a highly aerobic organism, which needs large amount of oxygen, especially in tissues characterized by high metabolic demand, such as the heart. Inadequate oxygen delivery underlies cardiovascular diseases, such as coronary artery disease, heart failure and pulmonary hypertension. Hemoglobin, the oxygen-transport metalloprotein in the red blood cells, gives the blood enormous oxygen carrying capacity; thus oxygen binding to hemoglobin in the lungs and oxygen dissociation in the target tissues are crucial points for oxygen delivery as well as potential targets for intervention. Myo-inositol trispyrophosphate (ITPP) acts as an effector of hemoglobin, shifting the oxygen dissociation curve to the right and increasing oxygen release in the target tissues, especially under hypoxic conditions. ITPP has been successfully used in cancer studies, demonstrating anti-cancer properties due to prevention of tumor hypoxia. Currently it is being tested in phase 2 clinical trials in humans with various tumors. First preclinical evidence also indicates that it can successfully alleviate myocardial hypoxia and prevent adverse left ventricular and right ventricular remodeling in post-myocardial infarction heart failure and pulmonary hypertension. The aim of the article is to summarize the current knowledge on ITTP, as well as to determine the prospects for its potential use in the treatment of many cardiovascular disorders." @default.
- W4292282969 created "2022-08-19" @default.
- W4292282969 creator A5005820758 @default.
- W4292282969 creator A5010991884 @default.
- W4292282969 creator A5058317825 @default.
- W4292282969 creator A5068617154 @default.
- W4292282969 creator A5008155203 @default.
- W4292282969 date "2022-10-01" @default.
- W4292282969 modified "2023-10-16" @default.
- W4292282969 title "New potential treatment for cardiovascular disease through modulation of hemoglobin oxygen binding curve: Myo-inositol trispyrophosphate (ITPP), from cancer to cardiovascular disease" @default.
- W4292282969 cites W1537427486 @default.
- W4292282969 cites W1981293397 @default.
- W4292282969 cites W1984397954 @default.
- W4292282969 cites W2001877320 @default.
- W4292282969 cites W2003266780 @default.
- W4292282969 cites W2004681996 @default.
- W4292282969 cites W2010353217 @default.
- W4292282969 cites W2036241566 @default.
- W4292282969 cites W2046456997 @default.
- W4292282969 cites W2067953773 @default.
- W4292282969 cites W2072307720 @default.
- W4292282969 cites W2072493397 @default.
- W4292282969 cites W2084903891 @default.
- W4292282969 cites W2085678794 @default.
- W4292282969 cites W2090845109 @default.
- W4292282969 cites W2093076321 @default.
- W4292282969 cites W2094751995 @default.
- W4292282969 cites W2109383180 @default.
- W4292282969 cites W2118421305 @default.
- W4292282969 cites W2129865306 @default.
- W4292282969 cites W2131798870 @default.
- W4292282969 cites W2137244712 @default.
- W4292282969 cites W2139581171 @default.
- W4292282969 cites W2140148084 @default.
- W4292282969 cites W2169699497 @default.
- W4292282969 cites W2196327977 @default.
- W4292282969 cites W2475019041 @default.
- W4292282969 cites W2488008276 @default.
- W4292282969 cites W2524601646 @default.
- W4292282969 cites W2541486080 @default.
- W4292282969 cites W2577653522 @default.
- W4292282969 cites W2606523656 @default.
- W4292282969 cites W2616163559 @default.
- W4292282969 cites W2625185012 @default.
- W4292282969 cites W2738891633 @default.
- W4292282969 cites W2785747592 @default.
- W4292282969 cites W2791728491 @default.
- W4292282969 cites W2899621095 @default.
- W4292282969 cites W2905614999 @default.
- W4292282969 cites W2990344386 @default.
- W4292282969 cites W2993897878 @default.
- W4292282969 cites W3000982988 @default.
- W4292282969 cites W3016364844 @default.
- W4292282969 cites W3035338176 @default.
- W4292282969 cites W3110570807 @default.
- W4292282969 cites W3132022705 @default.
- W4292282969 cites W3132176281 @default.
- W4292282969 cites W3154839158 @default.
- W4292282969 cites W3176803502 @default.
- W4292282969 cites W3197374235 @default.
- W4292282969 cites W4205457333 @default.
- W4292282969 cites W4206634989 @default.
- W4292282969 cites W4224140336 @default.
- W4292282969 doi "https://doi.org/10.1016/j.biopha.2022.113544" @default.
- W4292282969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35988421" @default.
- W4292282969 hasPublicationYear "2022" @default.
- W4292282969 type Work @default.
- W4292282969 citedByCount "2" @default.
- W4292282969 countsByYear W42922829692023 @default.
- W4292282969 crossrefType "journal-article" @default.
- W4292282969 hasAuthorship W4292282969A5005820758 @default.
- W4292282969 hasAuthorship W4292282969A5008155203 @default.
- W4292282969 hasAuthorship W4292282969A5010991884 @default.
- W4292282969 hasAuthorship W4292282969A5058317825 @default.
- W4292282969 hasAuthorship W4292282969A5068617154 @default.
- W4292282969 hasConcept C121608353 @default.
- W4292282969 hasConcept C126322002 @default.
- W4292282969 hasConcept C127503593 @default.
- W4292282969 hasConcept C164705383 @default.
- W4292282969 hasConcept C178790620 @default.
- W4292282969 hasConcept C185592680 @default.
- W4292282969 hasConcept C2778198053 @default.
- W4292282969 hasConcept C2778213512 @default.
- W4292282969 hasConcept C2778917026 @default.
- W4292282969 hasConcept C2779134260 @default.
- W4292282969 hasConcept C2780074459 @default.
- W4292282969 hasConcept C2780930700 @default.
- W4292282969 hasConcept C2993864201 @default.
- W4292282969 hasConcept C500558357 @default.
- W4292282969 hasConcept C540031477 @default.
- W4292282969 hasConcept C71924100 @default.
- W4292282969 hasConcept C7836513 @default.
- W4292282969 hasConcept C98274493 @default.
- W4292282969 hasConceptScore W4292282969C121608353 @default.
- W4292282969 hasConceptScore W4292282969C126322002 @default.
- W4292282969 hasConceptScore W4292282969C127503593 @default.
- W4292282969 hasConceptScore W4292282969C164705383 @default.
- W4292282969 hasConceptScore W4292282969C178790620 @default.