FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292291569> ?p ?o ?g. }

• W4292291569 endingPage "2539" @default.
• W4292291569 startingPage "2539" @default.
• W4292291569 abstract "In the past, proinflammatory CD11b+Ly6Chi monocytes were predominantly considered as a uniform population. However, recent investigations suggests that this population is far more diverse than previously thought. For example, in mouse models of Entamoeba (E.) histolytica and Listeria (L.) monocytogenes liver infections, it was shown that their absence had opposite effects. In the former model, it ameliorated parasite-dependent liver injury, whereas in the listeria model it exacerbated liver pathology. Here, we analyzed Ly6Chi monocytes from the liver of both infection models at transcriptome, protein, and functional levels. Paralleled by E. histolytica- and L. monocytogenes-specific differences in recruitment-relevant chemokines, both infections induced accumulation of Ly6C+ monocytes at infection sites. Transcriptomic analysis revealed a high similarity between monocytes from naïve and parasite-infected mice and a clear proinflammatory phenotype of listeria-induced monocytes. This was further reflected by the upregulation of M2-related transcription factors (e.g., Mafb, Nr4a1, Fos) and higher CD14 expression by Ly6Chi monocytes in the E. histolytica infection model. In contrast, monocytes from the listeria infection model expressed M1-related transcription factors (e.g., Irf2, Mndal, Ifi204) and showed higher expression of CD38, CD74, and CD86, as well as higher ROS production. Taken together, proinflammatory Ly6Chi monocytes vary considerably depending on the causative pathogen. By using markers identified in the study, Ly6Chi monocytes can be further subdivided into different populations." @default.
• W4292291569 created "2022-08-19" @default.
• W4292291569 creator A5020982328 @default.
• W4292291569 creator A5023009667 @default.
• W4292291569 creator A5026681835 @default.
• W4292291569 creator A5028432200 @default.
• W4292291569 creator A5028818563 @default.
• W4292291569 creator A5033790137 @default.
• W4292291569 creator A5039701255 @default.
• W4292291569 creator A5056143565 @default.
• W4292291569 creator A5057604968 @default.
• W4292291569 creator A5078030078 @default.
• W4292291569 creator A5084314416 @default.
• W4292291569 creator A5086719853 @default.
• W4292291569 creator A5089871953 @default.
• W4292291569 date "2022-08-16" @default.
• W4292291569 modified "2023-10-05" @default.
• W4292291569 title "The Properties of Proinflammatory Ly6Chi Monocytes Are Differentially Shaped by Parasitic and Bacterial Liver Infections" @default.
• W4292291569 cites W131012821 @default.
• W4292291569 cites W1797422316 @default.
• W4292291569 cites W1856650971 @default.
• W4292291569 cites W1964369726 @default.
• W4292291569 cites W1966834234 @default.
• W4292291569 cites W1969361825 @default.
• W4292291569 cites W2010472544 @default.
• W4292291569 cites W2026578487 @default.
• W4292291569 cites W2029906813 @default.
• W4292291569 cites W2051396047 @default.
• W4292291569 cites W2052422785 @default.
• W4292291569 cites W2055620105 @default.
• W4292291569 cites W2056778161 @default.
• W4292291569 cites W2065192517 @default.
• W4292291569 cites W2085099489 @default.
• W4292291569 cites W2094887427 @default.
• W4292291569 cites W2100820895 @default.
• W4292291569 cites W2117373786 @default.
• W4292291569 cites W2125558391 @default.
• W4292291569 cites W2135703618 @default.
• W4292291569 cites W2139708643 @default.
• W4292291569 cites W2142361972 @default.
• W4292291569 cites W2151362823 @default.
• W4292291569 cites W2153406260 @default.
• W4292291569 cites W2157758580 @default.
• W4292291569 cites W2158276327 @default.
• W4292291569 cites W2161048718 @default.
• W4292291569 cites W2165506911 @default.
• W4292291569 cites W2169456326 @default.
• W4292291569 cites W2179438025 @default.
• W4292291569 cites W2209250550 @default.
• W4292291569 cites W2339331239 @default.
• W4292291569 cites W2408483783 @default.
• W4292291569 cites W2466341281 @default.
• W4292291569 cites W2506722431 @default.
• W4292291569 cites W2546644646 @default.
• W4292291569 cites W2753114438 @default.
• W4292291569 cites W2769350174 @default.
• W4292291569 cites W2806759055 @default.
• W4292291569 cites W2810795907 @default.
• W4292291569 cites W2891747209 @default.
• W4292291569 cites W2900044275 @default.
• W4292291569 cites W2976606306 @default.
• W4292291569 cites W3002219094 @default.
• W4292291569 cites W3004348895 @default.
• W4292291569 cites W3014645561 @default.
• W4292291569 cites W3016532619 @default.
• W4292291569 cites W3033697948 @default.
• W4292291569 cites W3041001805 @default.
• W4292291569 cites W3049273902 @default.
• W4292291569 doi "https://doi.org/10.3390/cells11162539" @default.
• W4292291569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36010615" @default.
• W4292291569 hasPublicationYear "2022" @default.
• W4292291569 type Work @default.
• W4292291569 citedByCount "2" @default.
• W4292291569 countsByYear W42922915692023 @default.
• W4292291569 crossrefType "journal-article" @default.
• W4292291569 hasAuthorship W4292291569A5020982328 @default.
• W4292291569 hasAuthorship W4292291569A5023009667 @default.
• W4292291569 hasAuthorship W4292291569A5026681835 @default.
• W4292291569 hasAuthorship W4292291569A5028432200 @default.
• W4292291569 hasAuthorship W4292291569A5028818563 @default.
• W4292291569 hasAuthorship W4292291569A5033790137 @default.
• W4292291569 hasAuthorship W4292291569A5039701255 @default.
• W4292291569 hasAuthorship W4292291569A5056143565 @default.
• W4292291569 hasAuthorship W4292291569A5057604968 @default.
• W4292291569 hasAuthorship W4292291569A5078030078 @default.
• W4292291569 hasAuthorship W4292291569A5084314416 @default.
• W4292291569 hasAuthorship W4292291569A5086719853 @default.
• W4292291569 hasAuthorship W4292291569A5089871953 @default.
• W4292291569 hasBestOaLocation W42922915691 @default.
• W4292291569 hasConcept C13373296 @default.
• W4292291569 hasConcept C164027704 @default.
• W4292291569 hasConcept C203014093 @default.
• W4292291569 hasConcept C2776914184 @default.
• W4292291569 hasConcept C2778513237 @default.
• W4292291569 hasConcept C2781184567 @default.
• W4292291569 hasConcept C2781350384 @default.
• W4292291569 hasConcept C2908647359 @default.
• W4292291569 hasConcept C523546767 @default.

• next