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• W4292296645 abstract "Objectives To evaluate oxidative DNA damage (8-hydroxy-2′-deoxyguanosine [8-OHdG]) and its repair by the base excision repair pathway (Redox factor-1 [Ref-1]; X-ray Repair Cross Complementing-1 [XRCC-1]) in oral leukoplakia (OL) with different degrees of epithelial dysplasia (ED). Study Design Forty-four cases of OL and 10 normal oral mucosa (NOM) were evaluated quantitatively for 8-OHdG, Ref-1, and XRCC-1 by immunohistochemistry. Results Cytoplasmic 8-OHdG expression was significantly associated with multiple synchronous lesions (P = .048). A significantly gradual cytoplasmic 8-OHdG increase was observed between NOM and ED (P < .05). Nuclear Ref-1 expression was significantly lower (P = .004) in nondysplasia/mild ED, whereas its cytoplasmic expression was higher in nondysplasia/mild ED and moderate/severe ED compared to NOM (P = .03, P < .0001, respectively). Significantly higher cytoplasmic XRCC-1 expression in OL (P < .0001) was observed. Conclusions 8-OHdG plays a role in the onset of multiple synchronous OL and the severity of ED. The subcellular level of Ref-1 implies different roles according to the ED degree. Cytoplasmic XRCC-1 expression indicates a DNA repair mechanism failure during oral carcinogenesis. To evaluate oxidative DNA damage (8-hydroxy-2′-deoxyguanosine [8-OHdG]) and its repair by the base excision repair pathway (Redox factor-1 [Ref-1]; X-ray Repair Cross Complementing-1 [XRCC-1]) in oral leukoplakia (OL) with different degrees of epithelial dysplasia (ED). Forty-four cases of OL and 10 normal oral mucosa (NOM) were evaluated quantitatively for 8-OHdG, Ref-1, and XRCC-1 by immunohistochemistry. Cytoplasmic 8-OHdG expression was significantly associated with multiple synchronous lesions (P = .048). A significantly gradual cytoplasmic 8-OHdG increase was observed between NOM and ED (P < .05). Nuclear Ref-1 expression was significantly lower (P = .004) in nondysplasia/mild ED, whereas its cytoplasmic expression was higher in nondysplasia/mild ED and moderate/severe ED compared to NOM (P = .03, P < .0001, respectively). Significantly higher cytoplasmic XRCC-1 expression in OL (P < .0001) was observed. 8-OHdG plays a role in the onset of multiple synchronous OL and the severity of ED. The subcellular level of Ref-1 implies different roles according to the ED degree. Cytoplasmic XRCC-1 expression indicates a DNA repair mechanism failure during oral carcinogenesis." @default.
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• W4292296645 date "2022-09-01" @default.
• W4292296645 modified "2023-10-16" @default.
• W4292296645 title "OXIDATIVE DNA DAMAGE IN ORAL LEUKOPLAKIA AND ITS ROLE IN THE ORAL CARCINOGENESIS" @default.
• W4292296645 doi "https://doi.org/10.1016/j.oooo.2022.01.632" @default.
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