Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292307729> ?p ?o ?g. }
- W4292307729 endingPage "18" @default.
- W4292307729 startingPage "1" @default.
- W4292307729 abstract "Mitochondrial dysfunction, which can be regulated by mitophagy, plays a central role in diabetic neuropathic pain (DNP). Mitophagy that was involved in nerve damage-induced neuropathic pain has been reported. Hyperglycemia and cellular hypoxic were the two main characters of diabetes. Hypoxia-inducible factor 1α subunit (HIF-1α) plays a vital role in mitochondrial homeostasis under hypoxia. However, it remains unclear whether mitophagy was changed and could be regulated by HIF-1α in DNP. In this study, the results showed that mitophagy was activated and HIF-1α was upregulated in the spinal cord of diabetic mice. HIF-1α agonist dimethyloxalylglycine (DMOG) could further elevate HIF-1α and Parkin protein, enhance mitophagy, decrease mitochondrial dysfunction, and hyperalgesia. Furthermore, Park2 (encoding Parkin) knockout aggravated hyperalgesia and mitochondrial dysfunction in diabetic mice. Furthermore, mitophagy could not be activated and induced by HIF-1α agonist DMOG in Park2-/- diabetic mice. In this study, we first demonstrated that HIF-1α could upregulate mitophagy in the spinal cord of mice with DNP through modulating the Parkin signaling pathway, promoting new insights into the mechanisms and research of treatment strategies for patients with DNP." @default.
- W4292307729 created "2022-08-19" @default.
- W4292307729 creator A5004530167 @default.
- W4292307729 creator A5016917789 @default.
- W4292307729 creator A5028462736 @default.
- W4292307729 creator A5032016764 @default.
- W4292307729 creator A5045846049 @default.
- W4292307729 creator A5061415306 @default.
- W4292307729 creator A5063815351 @default.
- W4292307729 creator A5063981570 @default.
- W4292307729 creator A5071798264 @default.
- W4292307729 creator A5086273802 @default.
- W4292307729 date "2022-08-16" @default.
- W4292307729 modified "2023-09-30" @default.
- W4292307729 title "HIF-1α Ameliorates Diabetic Neuropathic Pain via Parkin-Mediated Mitophagy in a Mouse Model" @default.
- W4292307729 cites W1119410116 @default.
- W4292307729 cites W1877873625 @default.
- W4292307729 cites W1892359602 @default.
- W4292307729 cites W1904531393 @default.
- W4292307729 cites W1963521777 @default.
- W4292307729 cites W1965827991 @default.
- W4292307729 cites W1974939683 @default.
- W4292307729 cites W1983834354 @default.
- W4292307729 cites W1999847819 @default.
- W4292307729 cites W2019994842 @default.
- W4292307729 cites W2021439462 @default.
- W4292307729 cites W2023536633 @default.
- W4292307729 cites W2025714022 @default.
- W4292307729 cites W2034087770 @default.
- W4292307729 cites W2036511281 @default.
- W4292307729 cites W2037612627 @default.
- W4292307729 cites W2038976751 @default.
- W4292307729 cites W2054203136 @default.
- W4292307729 cites W2074599258 @default.
- W4292307729 cites W2108326484 @default.
- W4292307729 cites W2119399459 @default.
- W4292307729 cites W2121278724 @default.
- W4292307729 cites W2124709546 @default.
- W4292307729 cites W2135574023 @default.
- W4292307729 cites W2137091464 @default.
- W4292307729 cites W2140647923 @default.
- W4292307729 cites W2144785170 @default.
- W4292307729 cites W2149317862 @default.
- W4292307729 cites W2155015733 @default.
- W4292307729 cites W2255839210 @default.
- W4292307729 cites W2471605942 @default.
- W4292307729 cites W2474518039 @default.
- W4292307729 cites W2511165799 @default.
- W4292307729 cites W2597734448 @default.
- W4292307729 cites W2613819022 @default.
- W4292307729 cites W2622472435 @default.
- W4292307729 cites W2769264260 @default.
- W4292307729 cites W2774974877 @default.
- W4292307729 cites W2793323793 @default.
- W4292307729 cites W2803280843 @default.
- W4292307729 cites W2811133902 @default.
- W4292307729 cites W2909588616 @default.
- W4292307729 cites W2917347104 @default.
- W4292307729 cites W2944329919 @default.
- W4292307729 cites W2946842613 @default.
- W4292307729 cites W2964855767 @default.
- W4292307729 cites W2976176026 @default.
- W4292307729 cites W3000812022 @default.
- W4292307729 cites W3005211134 @default.
- W4292307729 cites W3087855098 @default.
- W4292307729 cites W4211145818 @default.
- W4292307729 cites W57484554 @default.
- W4292307729 doi "https://doi.org/10.1155/2022/5274375" @default.
- W4292307729 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36017378" @default.
- W4292307729 hasPublicationYear "2022" @default.
- W4292307729 type Work @default.
- W4292307729 citedByCount "2" @default.
- W4292307729 countsByYear W42923077292023 @default.
- W4292307729 crossrefType "journal-article" @default.
- W4292307729 hasAuthorship W4292307729A5004530167 @default.
- W4292307729 hasAuthorship W4292307729A5016917789 @default.
- W4292307729 hasAuthorship W4292307729A5028462736 @default.
- W4292307729 hasAuthorship W4292307729A5032016764 @default.
- W4292307729 hasAuthorship W4292307729A5045846049 @default.
- W4292307729 hasAuthorship W4292307729A5061415306 @default.
- W4292307729 hasAuthorship W4292307729A5063815351 @default.
- W4292307729 hasAuthorship W4292307729A5063981570 @default.
- W4292307729 hasAuthorship W4292307729A5071798264 @default.
- W4292307729 hasAuthorship W4292307729A5086273802 @default.
- W4292307729 hasBestOaLocation W42923077291 @default.
- W4292307729 hasConcept C104317684 @default.
- W4292307729 hasConcept C126322002 @default.
- W4292307729 hasConcept C127561419 @default.
- W4292307729 hasConcept C134018914 @default.
- W4292307729 hasConcept C15490471 @default.
- W4292307729 hasConcept C169760540 @default.
- W4292307729 hasConcept C170493617 @default.
- W4292307729 hasConcept C185592680 @default.
- W4292307729 hasConcept C190283241 @default.
- W4292307729 hasConcept C203522944 @default.
- W4292307729 hasConcept C2777107010 @default.
- W4292307729 hasConcept C2777668072 @default.
- W4292307729 hasConcept C2778938600 @default.