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- W4292313595 abstract "In cancer cells, metabolic reprogramming is associated with an alteration of the O-GlcNAcylation homeostasis. This post-translational modification (PTM) that attaches O-GlcNAc moiety to intracellular proteins is dynamically and finely regulated by the O-GlcNAc Transferase (OGT) and the O-GlcNAcase (OGA). It is now established that O-GlcNAcylation participates in many features of cancer cells including a high rate of cell growth, invasion, and metastasis but little is known about its impact on the response to therapies. The purpose of this review is to highlight the role of O-GlcNAc protein modification in cancer resistance to therapies. We summarize the current knowledge about the crosstalk between O-GlcNAcylation and molecular mechanisms underlying tumor sensitivity/resistance to targeted therapies, chemotherapies, immunotherapy, and radiotherapy. We also discuss potential benefits and strategies of targeting O-GlcNAcylation to overcome cancer resistance." @default.
- W4292313595 created "2022-08-19" @default.
- W4292313595 creator A5002960934 @default.
- W4292313595 creator A5004534583 @default.
- W4292313595 date "2022-08-17" @default.
- W4292313595 modified "2023-10-14" @default.
- W4292313595 title "Targeting O-GlcNAcylation to overcome resistance to anti-cancer therapies" @default.
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