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- W4292314922 abstract "Abstract Measurement of adherence to oral pre-exposure prophylaxis (PrEP) in real-time has been challenging. We developed DOT Diary, a smartphone application that combines automated directly observed therapy with a PrEP adherence visualization toolkit, and tested its ability to measure PrEP adherence and to increase adherence among a diverse cohort of young men who have sex with men (MSM). We enrolled 100 MSM in San Francisco and Atlanta and randomly assigned them 2:1 to DOT Diary versus standard of care. Concordance between DOT Diary measurement and drug levels in dried blood spots was substantial, with 91.0% and 85.3% concordance between DOT Diary and emtricitabine-triphosphate and tenofovir-diphosphate, respectively. There was no significant difference in the proportion of participants with detectable PrEP drug levels at 24 weeks between study arms. These results suggest DOT Diary is substantially better than self-reported measures of adherence, but additional interventions are needed to improve PrEP adherence over time." @default.
- W4292314922 created "2022-08-19" @default.
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- W4292314922 date "2022-08-19" @default.
- W4292314922 modified "2023-10-06" @default.
- W4292314922 title "Randomized Controlled Trial of Automated Directly Observed Therapy for Measurement and Support of PrEP Adherence Among Young Men Who have Sex with Men" @default.
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- W4292314922 doi "https://doi.org/10.1007/s10461-022-03805-3" @default.
- W4292314922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35984607" @default.
- W4292314922 hasPublicationYear "2022" @default.
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