Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292332807> ?p ?o ?g. }
- W4292332807 abstract "In the last decades, the concept of preclinical rheumatoid arthritis (RA) has become established. In fact, the discovery that disease mechanisms start years before the onset of clinical RA has been one of the major recent insights in the understanding of RA pathogenesis. In accordance with the complex nature of the disease, preclinical events extend over several sequential phases. In a genetically predisposed host, environmental factors will further increase susceptibility for incident RA. In the initial steps of preclinical disease, immune disturbance mechanisms take place outside the joint compartment, namely in mucosal surfaces, such as the lung, gums or gut. Herein, the persistent immunologic response to altered antigens will lead to breach of tolerance and trigger autoimmunity. In a second phase, the immune response matures and is amplified at a systemic level, with epitope spreading and widening of the autoantibody repertoire. Finally, the synovial and bone compartment are targeted by specific autoantibodies against modified antigens, initiating a local inflammatory response that will eventually culminate in clinically evident synovitis. In this review, we discuss the elaborate disease mechanisms in place during preclinical RA, providing a broad perspective in the light of current evidence." @default.
- W4292332807 created "2022-08-19" @default.
- W4292332807 creator A5017617307 @default.
- W4292332807 creator A5043747371 @default.
- W4292332807 date "2022-08-19" @default.
- W4292332807 modified "2023-09-30" @default.
- W4292332807 title "Disease mechanisms in preclinical rheumatoid arthritis: A narrative review" @default.
- W4292332807 cites W1137513493 @default.
- W4292332807 cites W1155857603 @default.
- W4292332807 cites W1166389763 @default.
- W4292332807 cites W1247177501 @default.
- W4292332807 cites W1493134746 @default.
- W4292332807 cites W1549470277 @default.
- W4292332807 cites W1582344203 @default.
- W4292332807 cites W1751722025 @default.
- W4292332807 cites W1790082869 @default.
- W4292332807 cites W1820310789 @default.
- W4292332807 cites W1832022780 @default.
- W4292332807 cites W1868076121 @default.
- W4292332807 cites W1901640178 @default.
- W4292332807 cites W1917207513 @default.
- W4292332807 cites W1925892179 @default.
- W4292332807 cites W1928614391 @default.
- W4292332807 cites W1933626256 @default.
- W4292332807 cites W1936939552 @default.
- W4292332807 cites W1943338444 @default.
- W4292332807 cites W1965399166 @default.
- W4292332807 cites W1965551666 @default.
- W4292332807 cites W1967211753 @default.
- W4292332807 cites W1967240061 @default.
- W4292332807 cites W1969337384 @default.
- W4292332807 cites W1972171465 @default.
- W4292332807 cites W1972616962 @default.
- W4292332807 cites W1973652618 @default.
- W4292332807 cites W1974718865 @default.
- W4292332807 cites W1975829694 @default.
- W4292332807 cites W1978296336 @default.
- W4292332807 cites W1980024538 @default.
- W4292332807 cites W1980379994 @default.
- W4292332807 cites W1981088485 @default.
- W4292332807 cites W1983929025 @default.
- W4292332807 cites W1988094624 @default.
- W4292332807 cites W1996220958 @default.
- W4292332807 cites W1996786164 @default.
- W4292332807 cites W1998890104 @default.
- W4292332807 cites W1999850359 @default.
- W4292332807 cites W2001775594 @default.
- W4292332807 cites W2002401357 @default.
- W4292332807 cites W2005699747 @default.
- W4292332807 cites W2006547485 @default.
- W4292332807 cites W2007205421 @default.
- W4292332807 cites W2009103286 @default.
- W4292332807 cites W2009343967 @default.
- W4292332807 cites W2015690685 @default.
- W4292332807 cites W2015865604 @default.
- W4292332807 cites W2016370312 @default.
- W4292332807 cites W2016382347 @default.
- W4292332807 cites W2017290170 @default.
- W4292332807 cites W2017716166 @default.
- W4292332807 cites W2018987167 @default.
- W4292332807 cites W2019427304 @default.
- W4292332807 cites W2019582534 @default.
- W4292332807 cites W2021296708 @default.
- W4292332807 cites W2023976647 @default.
- W4292332807 cites W2024988150 @default.
- W4292332807 cites W2025408360 @default.
- W4292332807 cites W2028934624 @default.
- W4292332807 cites W2031823694 @default.
- W4292332807 cites W2032362610 @default.
- W4292332807 cites W2045590518 @default.
- W4292332807 cites W2049219670 @default.
- W4292332807 cites W2052399844 @default.
- W4292332807 cites W2053293872 @default.
- W4292332807 cites W2057443097 @default.
- W4292332807 cites W2058443096 @default.
- W4292332807 cites W2059353973 @default.
- W4292332807 cites W2059695215 @default.
- W4292332807 cites W2061682029 @default.
- W4292332807 cites W2062526524 @default.
- W4292332807 cites W2062566352 @default.
- W4292332807 cites W2064349379 @default.
- W4292332807 cites W2065013393 @default.
- W4292332807 cites W2065047098 @default.
- W4292332807 cites W2065734531 @default.
- W4292332807 cites W2067645583 @default.
- W4292332807 cites W2070890108 @default.
- W4292332807 cites W2072460496 @default.
- W4292332807 cites W2082991836 @default.
- W4292332807 cites W2083959000 @default.
- W4292332807 cites W2084515988 @default.
- W4292332807 cites W2084707696 @default.
- W4292332807 cites W2085096810 @default.
- W4292332807 cites W2085192554 @default.
- W4292332807 cites W2086101419 @default.
- W4292332807 cites W2086755979 @default.
- W4292332807 cites W2089920716 @default.
- W4292332807 cites W2090131412 @default.
- W4292332807 cites W2090407312 @default.
- W4292332807 cites W2090489482 @default.
- W4292332807 cites W2096966555 @default.