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- W4292341110 abstract "Cell-based therapies offer an exciting and novel treatment for heart repair following myocardial infarction (MI). However, these therapies often suffer from poor cell viability and engraftment rates, which involve many factors, including the hypoxic conditions of the infarct environment. Meanwhile, vascular endothelial growth factor (VEGF) has previously been employed as a therapeutic agent to limit myocardial damage and simultaneously induce neovascularization. This study took an approach to transiently overexpress VEGF protein, in a controlled manner, by transfecting human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) with VEGF mRNA prior to transplantation. The conditioning of iPSC-CMs with VEGF mRNA ultimately led to greater survival rates of the transplanted cells, which promoted a stable vascular network in the grafted region. Furthermore, bulk RNA transcriptomics data and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed that phosphoinositide 3-kinase (PI3K)-protein kinase B (Akt) and AGE-RAGE signaling pathways were significantly upregulated in the VEGF-treated iPSC-CMs group. The over-expression of VEGF from iPSC-CMs stimulated cell proliferation and partially attenuated the hypoxic environment in the infarcted area, resulting in reduced ventricular remodeling. This study provides a valuable solution for the survival of transplanted cells in tissue-engineered heart regeneration and may further promote the application of modified mRNA (modRNA) in the field of tissue engineering." @default.
- W4292341110 created "2022-08-19" @default.
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- W4292341110 date "2023-01-01" @default.
- W4292341110 modified "2023-10-07" @default.
- W4292341110 title "Transient secretion of VEGF protein from transplanted hiPSC-CMs enhances engraftment and improves rat heart function post MI" @default.
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- W4292341110 cites W1993554607 @default.
- W4292341110 cites W1996575975 @default.
- W4292341110 cites W2015618974 @default.
- W4292341110 cites W2016680045 @default.
- W4292341110 cites W2023014134 @default.
- W4292341110 cites W2033624366 @default.
- W4292341110 cites W2051206599 @default.
- W4292341110 cites W2054540361 @default.
- W4292341110 cites W2057938879 @default.
- W4292341110 cites W2058692258 @default.
- W4292341110 cites W2060565064 @default.
- W4292341110 cites W2065168340 @default.
- W4292341110 cites W2082091110 @default.
- W4292341110 cites W2083599207 @default.
- W4292341110 cites W2086294280 @default.
- W4292341110 cites W2086464428 @default.
- W4292341110 cites W2086876030 @default.
- W4292341110 cites W2087419032 @default.
- W4292341110 cites W2090041902 @default.
- W4292341110 cites W2096237299 @default.
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- W4292341110 cites W2118402202 @default.
- W4292341110 cites W2119841264 @default.
- W4292341110 cites W2121166230 @default.
- W4292341110 cites W2126617987 @default.
- W4292341110 cites W2136122531 @default.
- W4292341110 cites W2152597627 @default.
- W4292341110 cites W2159348812 @default.
- W4292341110 cites W2160717085 @default.
- W4292341110 cites W2162482990 @default.
- W4292341110 cites W2164425162 @default.
- W4292341110 cites W2165162226 @default.
- W4292341110 cites W2166564847 @default.
- W4292341110 cites W2169859308 @default.
- W4292341110 cites W2177707018 @default.
- W4292341110 cites W2197175751 @default.
- W4292341110 cites W2200311017 @default.
- W4292341110 cites W2227274813 @default.
- W4292341110 cites W2300734873 @default.
- W4292341110 cites W2478832878 @default.
- W4292341110 cites W2528173482 @default.
- W4292341110 cites W2569102390 @default.
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- W4292341110 cites W2603453711 @default.
- W4292341110 cites W2736437772 @default.
- W4292341110 cites W2747325906 @default.
- W4292341110 cites W2761278051 @default.
- W4292341110 cites W2782863682 @default.
- W4292341110 cites W2789015856 @default.
- W4292341110 cites W2797607167 @default.
- W4292341110 cites W2887155754 @default.
- W4292341110 cites W2889425610 @default.
- W4292341110 cites W2892136976 @default.
- W4292341110 cites W2900621847 @default.
- W4292341110 cites W2943497585 @default.
- W4292341110 cites W2969208689 @default.
- W4292341110 cites W2975365532 @default.
- W4292341110 cites W3005591321 @default.
- W4292341110 cites W3029730275 @default.
- W4292341110 cites W3037288883 @default.
- W4292341110 cites W3038460051 @default.
- W4292341110 cites W3042581503 @default.
- W4292341110 cites W3045067389 @default.
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- W4292341110 doi "https://doi.org/10.1016/j.ymthe.2022.08.012" @default.
- W4292341110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35982619" @default.
- W4292341110 hasPublicationYear "2023" @default.
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