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• W4292357029 abstract "Objective. The goals of this study are to assess the correlation between 24-hour ambulatory blood pressure (BP) variability and white matter lesions (WML) in patients with cerebral small vascular disease (CSVD) and to provide guidance for the prevention of WML. Methods. A total of 136 patients diagnosed with CSVD and essential hypertension were recruited and divided into two groups. The Fazekas scale was used to quantify the severity of WML. The basic information, BP levels, BP variability, and circadian rhythm changes across these groups were recorded and compared. Results. The control group consisted of 40 subjects without WML ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M1> <mtext>Fazekas</mtext> <mtext> </mtext> <mtext>score</mtext> <mo>=</mo> <mn>0</mn> </math> ), and the WML group was composed of 96 patients with WML ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M2> <mtext>Fazekas</mtext> <mtext> </mtext> <mtext>score</mtext> <mo>≥</mo> <mn>1</mn> </math> ). Patients in the WML group were then divided into three subgroups: mild WML ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M3> <mi>n</mi> <mo>=</mo> <mn>43</mn> </math> , <math xmlns=http://www.w3.org/1998/Math/MathML id=M4> <mtext>Fazekas</mtext> <mtext> </mtext> <mtext>score</mtext> <mo>=</mo> <mn>1</mn> </math> ), moderate WML ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M5> <mi>n</mi> <mo>=</mo> <mn>24</mn> </math> , <math xmlns=http://www.w3.org/1998/Math/MathML id=M6> <mtext>Fazekas</mtext> <mtext> </mtext> <mtext>score</mtext> <mo>=</mo> <mn>2</mn> </math> ), and severe WML ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M7> <mi>n</mi> <mo>=</mo> <mn>29</mn> </math> , <math xmlns=http://www.w3.org/1998/Math/MathML id=M8> <mtext>Fazekas</mtext> <mtext> </mtext> <mtext>score</mtext> <mo>=</mo> <mn>3</mn> <mo>–</mo> <mn>4</mn> </math> ). Age, history of diabetes, and serum uric acid levels were significantly increased between the WML and control groups ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M9> <mi>P</mi> <mo><</mo> <mn>0.05</mn> </math> ). The levels of 24-hour mean diastolic BP ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M10> <mi>F</mi> <mo>=</mo> <mn>3.158</mn> </math> , <math xmlns=http://www.w3.org/1998/Math/MathML id=M11> <mi>P</mi> <mo>=</mo> <mn>0.026</mn> </math> ) and daytime mean systolic BP ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M12> <mi>F</mi> <mo>=</mo> <mn>3.526</mn> </math> , <math xmlns=http://www.w3.org/1998/Math/MathML id=M13> <mi>P</mi> <mo>=</mo> <mn>0.017</mn> </math> ) were significantly increased between the control and WML groups. There was no significant difference in the rhythmic classification of BP among all groups ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M14> <mi>P</mi> <mo>></mo> <mn>0.05</mn> </math> ). An ordered multinomial logistic regression analysis revealed that age, triglyceride levels, and nondipper BP were independent risk factors in WML. Conclusion. Age, history of diabetes, serum uric acid levels, 24-hour mean systolic level, and daily mean systolic BP level were significantly increased between the WML and control groups. Age, triglyceride levels, and nondipper BP were independent risk factors in WML in patients with CSVD, while the 24-hour dynamic blood pressure standard deviation and 24-hour dynamic blood pressure coefficient of variation were not associated with the occurrence of WML." @default.
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• W4292357029 date "2022-08-08" @default.
• W4292357029 modified "2023-10-10" @default.
• W4292357029 title "Correlation between 24-Hour Ambulatory Blood Pressure Variability and White Matter Lesions in Patients with Cerebral Small Vascular Disease: A Cross-Sectional Study" @default.
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• W4292357029 doi "https://doi.org/10.1155/2022/6364769" @default.
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