Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292360269> ?p ?o ?g. }
- W4292360269 abstract "We have identified active enhancers in the mouse cerebellum at embryonic and postnatal stages which provides a view of novel enhancers active during cerebellar development. The majority of cerebellar enhancers have dynamic activity between embryonic and postnatal development. Cerebellar enhancers were enriched for neural transcription factor binding sites with temporally specific expression. Putative gene targets displayed spatially restricted expression patterns, indicating cell-type specific expression regulation. Functional analysis of target genes indicated that enhancers regulate processes spanning several developmental epochs such as specification, differentiation and maturation. We use these analyses to discover one novel regulator and one novel marker of cerebellar development: Bhlhe22 and Pax3, respectively. We identified an enrichment of de novo mutations and variants associated with autism spectrum disorder in cerebellar enhancers. Furthermore, by comparing our data with relevant brain development ENCODE histone profiles and cerebellar single-cell datasets we have been able to generalize and expand on the presented analyses, respectively. We have made the results of our analyses available online in the Developing Mouse Cerebellum Enhancer Atlas , where our dataset can be efficiently queried, curated and exported by the scientific community to facilitate future research efforts. Our study provides a valuable resource for studying the dynamics of gene expression regulation by enhancers in the developing cerebellum and delivers a rich dataset of novel gene-enhancer associations providing a basis for future in-depth studies in the cerebellum." @default.
- W4292360269 created "2022-08-20" @default.
- W4292360269 creator A5016295259 @default.
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- W4292360269 date "2022-08-09" @default.
- W4292360269 modified "2023-10-17" @default.
- W4292360269 title "Temporal analysis of enhancers during mouse cerebellar development reveals dynamic and novel regulatory functions" @default.
- W4292360269 cites W1549348414 @default.
- W4292360269 cites W1576952949 @default.
- W4292360269 cites W1581187181 @default.
- W4292360269 cites W1834862890 @default.
- W4292360269 cites W1837829179 @default.
- W4292360269 cites W1965294797 @default.
- W4292360269 cites W1965626594 @default.
- W4292360269 cites W1967463767 @default.
- W4292360269 cites W1971139891 @default.
- W4292360269 cites W1972232405 @default.
- W4292360269 cites W1972538107 @default.
- W4292360269 cites W1981030303 @default.
- W4292360269 cites W1981045324 @default.
- W4292360269 cites W1984693685 @default.
- W4292360269 cites W1986223165 @default.
- W4292360269 cites W1986586739 @default.
- W4292360269 cites W1996203485 @default.
- W4292360269 cites W1998630795 @default.
- W4292360269 cites W1999498057 @default.
- W4292360269 cites W2000918925 @default.
- W4292360269 cites W2001142544 @default.
- W4292360269 cites W2013785611 @default.
- W4292360269 cites W2014677321 @default.
- W4292360269 cites W2015845481 @default.
- W4292360269 cites W2021341670 @default.
- W4292360269 cites W2028224079 @default.
- W4292360269 cites W2030346902 @default.
- W4292360269 cites W2031133527 @default.
- W4292360269 cites W2033201031 @default.
- W4292360269 cites W2035618305 @default.
- W4292360269 cites W2041171293 @default.
- W4292360269 cites W2043500082 @default.
- W4292360269 cites W2045257932 @default.
- W4292360269 cites W2048263136 @default.
- W4292360269 cites W2051201017 @default.
- W4292360269 cites W2051588335 @default.
- W4292360269 cites W2052463507 @default.
- W4292360269 cites W2059386911 @default.
- W4292360269 cites W2060983457 @default.
- W4292360269 cites W2063786220 @default.
- W4292360269 cites W2063815548 @default.
- W4292360269 cites W2068206509 @default.
- W4292360269 cites W2070021921 @default.
- W4292360269 cites W2079978621 @default.
- W4292360269 cites W2082036307 @default.
- W4292360269 cites W2085583998 @default.
- W4292360269 cites W2087833268 @default.
- W4292360269 cites W2089138901 @default.
- W4292360269 cites W2090875715 @default.
- W4292360269 cites W2099035230 @default.
- W4292360269 cites W2100826819 @default.
- W4292360269 cites W2102619694 @default.
- W4292360269 cites W2107277218 @default.
- W4292360269 cites W2110496051 @default.
- W4292360269 cites W2119521084 @default.
- W4292360269 cites W2120288525 @default.
- W4292360269 cites W2124514674 @default.
- W4292360269 cites W2124985265 @default.
- W4292360269 cites W2125484558 @default.
- W4292360269 cites W2126551936 @default.
- W4292360269 cites W2137187022 @default.
- W4292360269 cites W2141511286 @default.
- W4292360269 cites W2148611256 @default.
- W4292360269 cites W2150506261 @default.
- W4292360269 cites W2152642144 @default.
- W4292360269 cites W2164781867 @default.
- W4292360269 cites W2171357033 @default.
- W4292360269 cites W2171808845 @default.
- W4292360269 cites W2192080449 @default.
- W4292360269 cites W2341539131 @default.
- W4292360269 cites W2346143774 @default.
- W4292360269 cites W2375595029 @default.
- W4292360269 cites W2460346852 @default.
- W4292360269 cites W2484001856 @default.
- W4292360269 cites W2516701482 @default.
- W4292360269 cites W2591909999 @default.
- W4292360269 cites W2759693465 @default.
- W4292360269 cites W2765567136 @default.
- W4292360269 cites W2774801370 @default.
- W4292360269 cites W2781757746 @default.
- W4292360269 cites W2782160930 @default.
- W4292360269 cites W2782424591 @default.
- W4292360269 cites W2786174959 @default.
- W4292360269 cites W2790089517 @default.
- W4292360269 cites W2794231744 @default.
- W4292360269 cites W2809919828 @default.