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- W429236472 abstract "In neural stem cells (NSCs), glycoconjugates and carbohydrate antigens are known to serve as excellent biomarkers for cellular differentiation and to play functional roles in determining cell fate. O-Linked β-N-acetylglucosamine (O-GlcNAc) modifying nuclear and cytoplasmic proteins on the serine/threonine residues is also expected to play the regulatory roles. It is not known, however, if O-GlcNAc modification is expressed in NSCs and what the function of this expression is. In this study, we evaluated the patterns and possible functions O-GlcNAcylation in mouse embryonic neuroepithelial cells (NECs) which are rich in NSCs. We found the expression of O-GlcNAc transferase, O-GlcNAcase, and a number of O-GlcNAcylated proteins in NECs. Treatment of NECs with O-GlcNAcase inhibitors induced robust O-GlcNAc accumulation in NECs and reduction of the cell number. In O-GlcNAcase inhibitor-treated NECs, the Ras-MAPK pathway and the PI3K-Akt pathway, important for proliferation and survival, respectively, were intact, but caspase-3, an executioner of cell death, was activated. These results suggest that O-GlcNAc is involved in cell death signaling in NECs. Furthermore, we identified an O-GlcNAc-modified protein, Sp1 transcription factor. This work was supported by USPHS grants NS11853, AG027199 and a grant from the Childrens' Medical Research Foundation, Chicago, IL." @default.
- W429236472 created "2016-06-24" @default.
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- W429236472 date "2009-04-01" @default.
- W429236472 modified "2023-10-16" @default.
- W429236472 title "O‐GlcNAc modification of proteins in mouse embryonic neural stem cells" @default.
- W429236472 doi "https://doi.org/10.1096/fasebj.23.1_supplement.693.7" @default.
- W429236472 hasPublicationYear "2009" @default.
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