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- W4292367747 abstract "Abstract The JAK-STAT signalling pathway plays a key role in cytokine signalling and is involved in development, immunity, and tumorigenesis for nearly any cell. At first glance, the JAK-STAT signalling pathway appears to be straight forward. However, on closer examination, there are many different factors influencing the JAK and the STAT proteins, which even so cannot sufficiently explain the wide variety of the cell's responses to the large number of cytokines. The JAK-STAT signalling pathway has been, and still is, subject of basic research and offers an enormous potential for the development of new methods of personalised medicine and thus the translation of basic molecular research into clinical practice beyond the use of JAK inhibitors. Gain-of-function and loss-of-function mutations in the two immunologically particularly relevant signal transducers STAT1 and STAT3 present themselves through individual phenotypic clinical pictures. This review is intended to provide an overview of these specific syndromes and to summarise current findings on pathomechanism, symptoms, immunological features and therapeutic options of STAT1, STAT3, JAK1 and JAK3 loss-of-function and gain-of-function diseases." @default.
- W4292367747 created "2022-08-20" @default.
- W4292367747 creator A5000930246 @default.
- W4292367747 creator A5036421404 @default.
- W4292367747 creator A5054697494 @default.
- W4292367747 creator A5070228992 @default.
- W4292367747 creator A5080699101 @default.
- W4292367747 date "2022-08-19" @default.
- W4292367747 modified "2023-09-27" @default.
- W4292367747 title "The Goldilocks Principle of JAKs and STATs: Gain-of function mutations, loss-of-function mutations, and their clinical consequences" @default.
- W4292367747 cites W1509504924 @default.
- W4292367747 cites W1521367633 @default.
- W4292367747 cites W1560134280 @default.
- W4292367747 cites W1590794504 @default.
- W4292367747 cites W1601667381 @default.
- W4292367747 cites W1827723601 @default.
- W4292367747 cites W1970012513 @default.
- W4292367747 cites W1973238275 @default.
- W4292367747 cites W1994233311 @default.
- W4292367747 cites W1995353970 @default.
- W4292367747 cites W1995928670 @default.
- W4292367747 cites W1996005331 @default.
- W4292367747 cites W1996138383 @default.
- W4292367747 cites W2011742128 @default.
- W4292367747 cites W2017682773 @default.
- W4292367747 cites W2021437054 @default.
- W4292367747 cites W2022819740 @default.
- W4292367747 cites W2026772276 @default.
- W4292367747 cites W2028980130 @default.
- W4292367747 cites W2034038847 @default.
- W4292367747 cites W2038705787 @default.
- W4292367747 cites W2040831482 @default.
- W4292367747 cites W2042593266 @default.
- W4292367747 cites W2043901802 @default.
- W4292367747 cites W2051018333 @default.
- W4292367747 cites W2056107229 @default.
- W4292367747 cites W2072109427 @default.
- W4292367747 cites W2074390096 @default.
- W4292367747 cites W2079178172 @default.
- W4292367747 cites W2083104111 @default.
- W4292367747 cites W2084274092 @default.
- W4292367747 cites W2086121828 @default.
- W4292367747 cites W2093804554 @default.
- W4292367747 cites W2106512898 @default.
- W4292367747 cites W2107278930 @default.
- W4292367747 cites W2109224123 @default.
- W4292367747 cites W2114043064 @default.
- W4292367747 cites W2115044545 @default.
- W4292367747 cites W2130003099 @default.
- W4292367747 cites W2131418107 @default.
- W4292367747 cites W2133489484 @default.
- W4292367747 cites W2137440275 @default.
- W4292367747 cites W2143729842 @default.
- W4292367747 cites W2145968395 @default.
- W4292367747 cites W2159530833 @default.
- W4292367747 cites W2162790692 @default.
- W4292367747 cites W2172453490 @default.
- W4292367747 cites W2178197433 @default.
- W4292367747 cites W2253776931 @default.
- W4292367747 cites W2292791280 @default.
- W4292367747 cites W2329293925 @default.
- W4292367747 cites W2335963744 @default.
- W4292367747 cites W2337579752 @default.
- W4292367747 cites W2340870558 @default.
- W4292367747 cites W2342613314 @default.
- W4292367747 cites W2467020097 @default.
- W4292367747 cites W2568057136 @default.
- W4292367747 cites W2575587665 @default.
- W4292367747 cites W2579991322 @default.
- W4292367747 cites W2592674743 @default.
- W4292367747 cites W2593491675 @default.
- W4292367747 cites W2621105652 @default.
- W4292367747 cites W2735417632 @default.
- W4292367747 cites W2749321272 @default.
- W4292367747 cites W2770306723 @default.
- W4292367747 cites W2772004082 @default.
- W4292367747 cites W2793755038 @default.
- W4292367747 cites W2804271609 @default.
- W4292367747 cites W2807718031 @default.
- W4292367747 cites W2808427866 @default.
- W4292367747 cites W2808941341 @default.
- W4292367747 cites W2883803416 @default.
- W4292367747 cites W2886181943 @default.
- W4292367747 cites W2887787769 @default.
- W4292367747 cites W2892635078 @default.
- W4292367747 cites W2908728730 @default.
- W4292367747 cites W2916903727 @default.
- W4292367747 cites W2916946405 @default.
- W4292367747 cites W2917492917 @default.
- W4292367747 cites W2937292311 @default.
- W4292367747 cites W2944087535 @default.
- W4292367747 cites W2954425631 @default.
- W4292367747 cites W2955888220 @default.
- W4292367747 cites W2956030496 @default.
- W4292367747 cites W2963532101 @default.
- W4292367747 cites W2980972927 @default.
- W4292367747 cites W2990697662 @default.
- W4292367747 cites W3081194337 @default.
- W4292367747 cites W3096967998 @default.
- W4292367747 cites W3121068596 @default.