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- W4292369063 endingPage "821" @default.
- W4292369063 startingPage "807" @default.
- W4292369063 abstract "The systematic treatment of colorectal cancer (CRC) still has room for improvement. The efficacy of chemotherapy, that of anti-vascular therapy, and that of immunotherapy have been unsatisfactory. In recent years, nanomaterials have been used as carriers to improve the bioavailability of anticancer drugs. For the treatment of colorectal cancer, nanodrugs increase the possibility of more precise targeted delivery. However, the actual benefits may cover more aspects. Nanocarriers can produce synergistic effects with anticancer drugs, including the scavenging of reactive oxygen species and co-delivery of a variety of drugs. Currently, immunotherapy has very limited clinical applications in CRC. Modified nanocarriers can activate the immune microenvironment, which can be used for staging antigen recognition or the immune response. Cancer vaccines based on nanomaterials and modified immune checkpoint inhibitors have shown therapeutic potential in animal models. Considering the direct or indirect relationship between the intestinal microflora and CRC, a variety of nanodrugs that regulate microbial function have been explored as an anticancer strategy, and the special structure of microorganisms can also be used as a basis for improving the delivery of traditional nanoparticles (NPs). This review summarizes recent research performed on nanocarriers in in vivo and in vitro models and the synergistic anticancer effects of nanocarriers, focusing on the interaction between NPs and the body, resulting in enhanced efficacy and immune activation. Furthermore, this review describes the current trend of NPs used in the treatment of CRC." @default.
- W4292369063 created "2022-08-20" @default.
- W4292369063 creator A5003662438 @default.
- W4292369063 creator A5008891245 @default.
- W4292369063 creator A5030478182 @default.
- W4292369063 creator A5045553246 @default.
- W4292369063 creator A5053734887 @default.
- W4292369063 creator A5084614115 @default.
- W4292369063 date "2022-09-08" @default.
- W4292369063 modified "2023-10-17" @default.
- W4292369063 title "Research advances in nanomedicine applied to the systemic treatment of colorectal cancer" @default.
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