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- W4292372852 abstract "Gene therapy has revolutionized the field of medicine, offering new hope for those with common and rare diseases. For nearly three decades, adeno-associated virus (AAV) has shown significant therapeutic benefits in multiple clinical trials, mainly due to its unique replication defects and non-pathogenicity in humans. In the field of cardiovascular disease (CVD), compared with non-viral vectors, lentiviruses, poxviruses, and adenovirus vectors, AAV possesses several advantages, including high security, low immunogenicity, sustainable and stable exogenous gene expression etc., which makes AAV one of the most promising candidates for the treatment of many genetic disorders and hereditary diseases. In this review, we evaluate the current information on the immune responses, transport pathways, and mechanisms of action associated with AAV-based CVD gene therapies and further explore potential optimization strategies to improve the efficiency of AAV transduction for the improved safety and efficiency of CVD treatment. In conclusion, AAV-mediated gene therapy has great potential for development in the cardiovascular system." @default.
- W4292372852 created "2022-08-20" @default.
- W4292372852 creator A5029791756 @default.
- W4292372852 creator A5031817044 @default.
- W4292372852 creator A5039832836 @default.
- W4292372852 creator A5071540194 @default.
- W4292372852 creator A5082308725 @default.
- W4292372852 date "2022-08-19" @default.
- W4292372852 modified "2023-10-17" @default.
- W4292372852 title "AAV-mediated gene therapy: Advancing cardiovascular disease treatment" @default.
- W4292372852 cites W1605004657 @default.
- W4292372852 cites W1942774139 @default.
- W4292372852 cites W1947058321 @default.
- W4292372852 cites W1973769490 @default.
- W4292372852 cites W1978368006 @default.
- W4292372852 cites W1987102172 @default.
- W4292372852 cites W1994064996 @default.
- W4292372852 cites W1998165633 @default.
- W4292372852 cites W2005754597 @default.
- W4292372852 cites W2006920577 @default.
- W4292372852 cites W2008289270 @default.
- W4292372852 cites W2009247311 @default.
- W4292372852 cites W2010344791 @default.
- W4292372852 cites W2017275157 @default.
- W4292372852 cites W2032062609 @default.
- W4292372852 cites W2035146556 @default.
- W4292372852 cites W2042259141 @default.
- W4292372852 cites W2043182993 @default.
- W4292372852 cites W2046488302 @default.
- W4292372852 cites W2047760317 @default.
- W4292372852 cites W2049478082 @default.
- W4292372852 cites W2049958940 @default.
- W4292372852 cites W2078327940 @default.
- W4292372852 cites W2082109839 @default.
- W4292372852 cites W2085421615 @default.
- W4292372852 cites W2089808477 @default.
- W4292372852 cites W2090146642 @default.
- W4292372852 cites W2102693920 @default.
- W4292372852 cites W2110557028 @default.
- W4292372852 cites W2125449435 @default.
- W4292372852 cites W2128688403 @default.
- W4292372852 cites W2129423973 @default.
- W4292372852 cites W2131047305 @default.
- W4292372852 cites W2148120054 @default.
- W4292372852 cites W2148389596 @default.
- W4292372852 cites W2151316131 @default.
- W4292372852 cites W2153809726 @default.
- W4292372852 cites W2164545730 @default.
- W4292372852 cites W2168233533 @default.
- W4292372852 cites W2220787769 @default.
- W4292372852 cites W2233607944 @default.
- W4292372852 cites W2266837556 @default.
- W4292372852 cites W2271175958 @default.
- W4292372852 cites W2563937758 @default.
- W4292372852 cites W2569712664 @default.
- W4292372852 cites W2620919080 @default.
- W4292372852 cites W2625682046 @default.
- W4292372852 cites W2755887165 @default.
- W4292372852 cites W2773751112 @default.
- W4292372852 cites W2774511679 @default.
- W4292372852 cites W2783469117 @default.
- W4292372852 cites W2784821118 @default.
- W4292372852 cites W2791154661 @default.
- W4292372852 cites W2801955216 @default.
- W4292372852 cites W2802545170 @default.
- W4292372852 cites W2808110707 @default.
- W4292372852 cites W2837459302 @default.
- W4292372852 cites W2883442429 @default.
- W4292372852 cites W2889510460 @default.
- W4292372852 cites W2900003149 @default.
- W4292372852 cites W2913212173 @default.
- W4292372852 cites W2914873583 @default.
- W4292372852 cites W2945235463 @default.
- W4292372852 cites W2947610390 @default.
- W4292372852 cites W2948388341 @default.
- W4292372852 cites W2965814050 @default.
- W4292372852 cites W2991022372 @default.
- W4292372852 cites W2993890101 @default.
- W4292372852 cites W2996373122 @default.
- W4292372852 cites W3000219265 @default.
- W4292372852 cites W3001618585 @default.
- W4292372852 cites W3002082131 @default.
- W4292372852 cites W3002203125 @default.
- W4292372852 cites W3003995118 @default.
- W4292372852 cites W3004887743 @default.
- W4292372852 cites W3006379979 @default.
- W4292372852 cites W3010479900 @default.
- W4292372852 cites W3011078551 @default.
- W4292372852 cites W3015160048 @default.
- W4292372852 cites W3016405424 @default.
- W4292372852 cites W3026795448 @default.
- W4292372852 cites W3032166296 @default.
- W4292372852 cites W3041718992 @default.
- W4292372852 cites W3045060379 @default.
- W4292372852 cites W3086403051 @default.
- W4292372852 cites W3087030402 @default.
- W4292372852 cites W3088224260 @default.
- W4292372852 cites W3088924018 @default.
- W4292372852 cites W3092811898 @default.
- W4292372852 cites W3092913715 @default.