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- W4292377380 abstract "The goal of the development of targeted drug delivery systems is clinically useful formulations to improve therapeutic benefit and patient compliance. Current targeted drug delivery research has extensively focused on polymeric micelles for their smaller size, low toxicity, biodegradability, drug protection, relative ease of preparation, and optimization. Polymeric micelles are made up of hydrophilic shell polymer in the outer compartment and hydrophobic core in the inner compartment that carries and protects the drug. The properties and unique structure of polymeric micelles give an advantage in the preparation of excellent delivery vehicles for various applications. However, the challenges in developing targeted drug delivery systems are the ability to interact with target receptors and uptake by specific targeted cells. This chapter provides additional insight into cellular events and behavior in response to drug delivery systems and is not limited to engineering and biochemistry principles. It discusses the current targeting strategy and the characteristics of polymeric micelles that affect their interaction with the biological environment. Furthermore, it presents the studies that have successfully developed and improved polymeric micelles’ ability to interact with target cell receptors. In view of this, a deeper understanding of polymeric micelles’ properties and validation of the interaction with the biological environment will provide a promising achievement from preclinical to successful clinical settings to effectively treat a wide range of diseases." @default.
- W4292377380 created "2022-08-20" @default.
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- W4292377380 creator A5085773686 @default.
- W4292377380 creator A5091405085 @default.
- W4292377380 date "2022-01-01" @default.
- W4292377380 modified "2023-09-25" @default.
- W4292377380 title "Cellular interaction of polymeric micelles in targeted drug delivery systems: the road from tissue to cell" @default.
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