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• W4292386324 abstract "Abstract Background: Sepsis is the most common cause of death in hospitals, and intra-abdominal infection (IAI) accounts for a large portion of the causes of sepsis. We investigated the clinical outcomes and factors influencing mortality of patients with sepsis due to IAI. Methods: This post-hoc analysis of a prospective cohort study included 2,126 patients with sepsis who visited 16 tertiary care hospitals in Korea (September 2019–February 2020). The analysis included 219 patients aged > 19 years who were admitted to intensive care units owing to sepsis caused by IAI. Results: The incidence of septic shock was 47% and was significantly higher in the non-survivor group (58.7% vs 42.3%, p =0.028). The overall 28-day mortality was 28.8%. In multivariate logistic regression, after adjusting for age, sex, Charlson comorbidity index, and lactic acid, only coagulatory dysfunction ( p =0.001, odds ratio: 2.78 [1.47­–5.23]) was independently associated, and after adjusting for each risk factor, only simplified acute physiology score III ( p =0.014) and continuous renal replacement therapy ( p <0.001) were independently associated with higher 28-day mortality. Conclusions: Considering the independent risk factors influencing 28-day mortality, more intensive care may be needed for patients with coagulopathy than for patients with other organ dysfunctions caused by IAI." @default.
• W4292386324 created "2022-08-20" @default.
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• W4292386324 date "2022-08-19" @default.
• W4292386324 modified "2023-10-16" @default.
• W4292386324 title "Clinical outcomes and prognostic factors of patients with sepsis caused by intra-abdominal infection in the intensive care unit: A post-hoc analysis of a prospective cohort study in Korea" @default.
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• W4292386324 doi "https://doi.org/10.21203/rs.3.rs-1900275/v1" @default.
• W4292386324 hasPublicationYear "2022" @default.
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