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- W4292395481 abstract "Frederick Sanger (1918–2013) was a British biochemist who devised methods for determining the sequences of amino acids in proteins in the 1940s and for determining the sequences of nucleotides in nucleic acids in the 1970s. The two contributions were foundational for the field of molecular genetics and Sanger was recognized for these contributions with two Nobel prizes in chemistry, the only individual so honored. Sanger’s work from the time he was an undergraduate to his retirement was carried out in entirely in the department of biochemistry at Cambridge University. In addition to his appointment at Cambridge University, he joined the Medical Research Council’s Laboratory of Molecular Biology (in Cambridge) as head of its protein chemistry division upon its founding in 1962. Sanger’s early work provided the first amino acid sequence of a protein, insulin, the results of which clarified many open genetic problems, especially as related to the genetic code (e.g., the observation that there were no restrictions on the order of amino acids ruled out several proposed versions of the genetic code). Sanger’s laboratory generated much of the seminal work on nucleic acid and protein chemistry that allowed him and his collaborators to determine the first complete DNA sequences of several small phage genomes (φX174 and Lambda) and later, much larger animal viruses (Epstein Barr Virus). This work set the stage for the human genome project, a centerpiece of current genetic study." @default.
- W4292395481 created "2022-08-20" @default.
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- W4292395481 date "2022-01-01" @default.
- W4292395481 modified "2023-09-26" @default.
- W4292395481 title "Sanger, Frederick" @default.
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- W4292395481 doi "https://doi.org/10.1016/b978-0-12-822563-9.00039-1" @default.
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