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- W4292399650 startingPage "151940" @default.
- W4292399650 abstract "A primary underlying defect makes β-cells susceptible to no longer compensate for the peripheral insulin resistance and to trigger the onset of type 2 diabetes (T2D). New evidence suggests that in T2D, β-cells are not destroyed but experience a loss of identity, reverting to a progenitor-like state and largely losing the ability to sense glucose and produce insulin. We assessed (using fluorescence microscopy and histomorphometry correlated with the glycaemic status) the main β-cell identity modifications as diabetes progresses in the TallyHo/JngJ (TH) male mice, a polygenic model of spontaneous T2D, akin to the human phenotype. We found that: 1) conversion to overt diabetes is paralleled by a progressive reduction of insulin-expressing cells and expansion of a glucagon-positive population, together with alteration of islet size and shape; 2) the β-cell population is highly heterogeneous in terms of insulin content and specific transcription factors like PDX1 and NKX6.1, that are gradually lost during diabetes progression; 3) GLUT2 expression is altered early and strongly reduced at late stages of diabetes; 4) an endocrine developmental program dependent on NGN3-expressing progenitors is revived when hyperglycaemia becomes severe; and 5) the re-expression of the EMT-associated factor vimentin occurs as diabetes worsens, representing a possible regenerative response to β-cell loss. Based on these results, we formulated additional hypotheses for the β-cell identity alteration in the TH model, together with several limitations of the study, that constitute future research directions." @default.
- W4292399650 created "2022-08-20" @default.
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- W4292399650 date "2022-10-01" @default.
- W4292399650 modified "2023-09-26" @default.
- W4292399650 title "Heterogeneity and altered β-cell identity in the TallyHo model of early-onset type 2 diabetes" @default.
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- W4292399650 doi "https://doi.org/10.1016/j.acthis.2022.151940" @default.
- W4292399650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35969910" @default.
- W4292399650 hasPublicationYear "2022" @default.
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