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- W4292405972 abstract "Adipose tissue secretes an abundance of lipid and protein mediators, and this secretome is depot-specific, with local and systemic effects on metabolic regulation. Intermuscular adipose tissue (IMAT) accumulates within the skeletal muscle compartment in obesity, and is associated with insulin resistance and metabolic disease. While the human IMAT secretome decreases insulin sensitivity in vitro, its composition is entirely unknown. The current study was conducted to investigate the composition of the human IMAT secretome, compared to that of the subcutaneous (SAT) and visceral adipose tissue (VAT) depots. IMAT, SAT, and VAT explants from individuals with obesity were used to generate conditioned media. Proteomics analysis of conditioned media was performed using multiplex proximity extension assays, and eicosanoid analysis using liquid chromatography–tandem mass spectrometry. Compared to SAT and/or VAT, IMAT secreted significantly more cytokines (IL2, IL5, IL10, IL13, IL27, FGF23, IFNγ and CSF1) and chemokines (MCP1, IL8, CCL11, CCL20, CCL25 and CCL27). Adipokines hepatocyte growth factor and resistin were secreted significantly more by IMAT than SAT or VAT. IMAT secreted significantly more eicosanoids (PGE2, TXB2, 5-HETE, and 12-HETE) compared to SAT and/or VAT. In the context of obesity, IMAT is a distinct adipose tissue with a highly immunogenic and inflammatory secretome, and given its proximity to skeletal muscle, may be critical to glucose regulation and insulin resistance." @default.
- W4292405972 created "2022-08-20" @default.
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- W4292405972 date "2022-08-01" @default.
- W4292405972 modified "2023-10-14" @default.
- W4292405972 title "Quantifying the inflammatory secretome of human intermuscular adipose tissue" @default.
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- W4292405972 cites W1924084714 @default.
- W4292405972 cites W1966705749 @default.
- W4292405972 cites W1968476943 @default.
- W4292405972 cites W1974599416 @default.
- W4292405972 cites W1976015795 @default.
- W4292405972 cites W1976844022 @default.
- W4292405972 cites W1980660681 @default.
- W4292405972 cites W1988910684 @default.
- W4292405972 cites W1991079474 @default.
- W4292405972 cites W1994664562 @default.
- W4292405972 cites W1995253456 @default.
- W4292405972 cites W2007822694 @default.
- W4292405972 cites W2010084870 @default.
- W4292405972 cites W2014716738 @default.
- W4292405972 cites W2015088284 @default.
- W4292405972 cites W2016785848 @default.
- W4292405972 cites W2019580308 @default.
- W4292405972 cites W2023520187 @default.
- W4292405972 cites W2029667930 @default.
- W4292405972 cites W2029790299 @default.
- W4292405972 cites W2030571587 @default.
- W4292405972 cites W2030689322 @default.
- W4292405972 cites W2033127055 @default.
- W4292405972 cites W2033169193 @default.
- W4292405972 cites W2033869640 @default.
- W4292405972 cites W2033946555 @default.
- W4292405972 cites W2042339399 @default.
- W4292405972 cites W2056986474 @default.
- W4292405972 cites W2071286559 @default.
- W4292405972 cites W2074023056 @default.
- W4292405972 cites W2076633494 @default.
- W4292405972 cites W2077745556 @default.
- W4292405972 cites W2088238416 @default.
- W4292405972 cites W2094644629 @default.
- W4292405972 cites W2095592092 @default.
- W4292405972 cites W2098494341 @default.
- W4292405972 cites W2098676976 @default.
- W4292405972 cites W2099257000 @default.
- W4292405972 cites W2102285747 @default.
- W4292405972 cites W2104421238 @default.
- W4292405972 cites W2107886081 @default.
- W4292405972 cites W2109213928 @default.
- W4292405972 cites W2116890951 @default.
- W4292405972 cites W2125407302 @default.
- W4292405972 cites W2127054064 @default.
- W4292405972 cites W2127537627 @default.
- W4292405972 cites W2130388731 @default.
- W4292405972 cites W2134802533 @default.
- W4292405972 cites W2135523822 @default.
- W4292405972 cites W2139833921 @default.
- W4292405972 cites W2144341012 @default.
- W4292405972 cites W2144803025 @default.
- W4292405972 cites W2148722507 @default.
- W4292405972 cites W2151246490 @default.
- W4292405972 cites W2157429518 @default.
- W4292405972 cites W2160610888 @default.
- W4292405972 cites W2160915024 @default.
- W4292405972 cites W2165648585 @default.
- W4292405972 cites W2170651583 @default.
- W4292405972 cites W2179326985 @default.
- W4292405972 cites W2295738103 @default.
- W4292405972 cites W2409158180 @default.
- W4292405972 cites W2418078332 @default.
- W4292405972 cites W2429204979 @default.
- W4292405972 cites W2558605920 @default.
- W4292405972 cites W2587054273 @default.
- W4292405972 cites W2620406790 @default.
- W4292405972 cites W2774342186 @default.
- W4292405972 cites W2794106651 @default.
- W4292405972 cites W2794273898 @default.
- W4292405972 cites W2810102400 @default.
- W4292405972 cites W2890365959 @default.
- W4292405972 cites W2895708430 @default.
- W4292405972 cites W2909780617 @default.
- W4292405972 cites W2946644515 @default.
- W4292405972 cites W3021355249 @default.
- W4292405972 cites W4226263198 @default.
- W4292405972 cites W4250725029 @default.
- W4292405972 cites W4285719527 @default.
- W4292405972 cites W54801374 @default.
- W4292405972 doi "https://doi.org/10.14814/phy2.15424" @default.
- W4292405972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35980018" @default.
- W4292405972 hasPublicationYear "2022" @default.
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