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- W4292407505 abstract "The development of fluorescent probes based on the skeletal structure of small-molecule targeted anticancer drugs is promising for biomedical applications because these probes generally show trackable fluorescence and connatural bioactivity inherited from the parental anticancer drugs. By mimicking a classic estrogen receptor (ER) antagonist, namely, tamoxifen, we herein design and synthesize a photoactivatable luminogen with aggregation-induced emission and medicinal benefits. The probe is weakly emissive when it is selectively internalized by estrogen receptor-positive cells. Under photoirradiation, its emission can be turned on to report the intracellular distribution. The cell viability assay suggests that the probe only exhibits cytotoxicity to ER-positive cells but negligible cytotoxicity to ER-negative cells. This study thus provides new access to targeted theranostic systems with photoactivity." @default.
- W4292407505 created "2022-08-20" @default.
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- W4292407505 date "2022-08-18" @default.
- W4292407505 modified "2023-10-15" @default.
- W4292407505 title "A Photoactivatable AIEgen for Selective Imaging and Killing of Estrogen Receptor-Positive Cells" @default.
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- W4292407505 doi "https://doi.org/10.1021/acsmaterialslett.2c00529" @default.
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