FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292450679> ?p ?o ?g. }

• W4292450679 endingPage "81" @default.
• W4292450679 startingPage "72" @default.
• W4292450679 abstract "Acitretin is an oral drug approved by the Food and Drug Administration that is commonly used to treat psoriasis. In recent years, acitretin has been identified as a candidate drug for the treatment of Alzheimer's disease, but its role in neuronal development is still unclear. In this study, the human neuroblastoma cell line SH-SY5Y was used as a model to study neuronal differentiation. We found that acitretin effectively promoted the differentiation of SH-SY5Y cells into neuronal cells and upregulated the expression of the neuronal marker β-III tubulin and the mature neuronal marker NFH. Differentially expressed genes were identified by RNA sequencing and analyzed by bioinformatics approaches. The results showed that genes associated with neuron development-related pathways, such as SSPO and KCNT1, had significant changes in expression. Analysis showed that PRKCA and CAMK2B may play important roles in the process by which acitretin promotes neurodevelopment. Through whole-cell patch clamping and a microelectrode array assay, we found that acitretin-treated neurons generated electrical spikes similar to those generated by mature neurons. This study provided evidence to support an accessible and safe model of neuron-like cells and verified that acitretin can promote the differentiation of neurons and has the potential to treat brain tumors and neurodevelopmental and neurodegenerative diseases." @default.
• W4292450679 created "2022-08-20" @default.
• W4292450679 creator A5015330549 @default.
• W4292450679 creator A5022088613 @default.
• W4292450679 creator A5022814949 @default.
• W4292450679 creator A5035914897 @default.
• W4292450679 creator A5043421617 @default.
• W4292450679 creator A5073468737 @default.
• W4292450679 creator A5087369332 @default.
• W4292450679 creator A5073412843 @default.
• W4292450679 date "2022-08-20" @default.
• W4292450679 modified "2023-10-15" @default.
• W4292450679 title "In Vitro Effects of Acitretin on Human Neuronal SH-SY5Y Cells" @default.
• W4292450679 cites W1951878306 @default.
• W4292450679 cites W1975394753 @default.
• W4292450679 cites W2004803686 @default.
• W4292450679 cites W2013028438 @default.
• W4292450679 cites W2018821302 @default.
• W4292450679 cites W2021173451 @default.
• W4292450679 cites W2042449171 @default.
• W4292450679 cites W2080327158 @default.
• W4292450679 cites W2083700985 @default.
• W4292450679 cites W2109348594 @default.
• W4292450679 cites W2117145998 @default.
• W4292450679 cites W2118034163 @default.
• W4292450679 cites W2157636777 @default.
• W4292450679 cites W2281449070 @default.
• W4292450679 cites W2581824660 @default.
• W4292450679 cites W2758985612 @default.
• W4292450679 cites W2888201656 @default.
• W4292450679 cites W2997813581 @default.
• W4292450679 cites W3096719134 @default.
• W4292450679 cites W3136051851 @default.
• W4292450679 cites W3112630782 @default.
• W4292450679 doi "https://doi.org/10.1007/s11064-022-03716-8" @default.
• W4292450679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35987975" @default.
• W4292450679 hasPublicationYear "2022" @default.
• W4292450679 type Work @default.
• W4292450679 citedByCount "0" @default.
• W4292450679 crossrefType "journal-article" @default.
• W4292450679 hasAuthorship W4292450679A5015330549 @default.
• W4292450679 hasAuthorship W4292450679A5022088613 @default.
• W4292450679 hasAuthorship W4292450679A5022814949 @default.
• W4292450679 hasAuthorship W4292450679A5035914897 @default.
• W4292450679 hasAuthorship W4292450679A5043421617 @default.
• W4292450679 hasAuthorship W4292450679A5073412843 @default.
• W4292450679 hasAuthorship W4292450679A5073468737 @default.
• W4292450679 hasAuthorship W4292450679A5087369332 @default.
• W4292450679 hasBestOaLocation W42924506791 @default.
• W4292450679 hasConcept C104317684 @default.
• W4292450679 hasConcept C148738053 @default.
• W4292450679 hasConcept C169760540 @default.
• W4292450679 hasConcept C203014093 @default.
• W4292450679 hasConcept C2776715637 @default.
• W4292450679 hasConcept C2778496887 @default.
• W4292450679 hasConcept C2778794669 @default.
• W4292450679 hasConcept C2779083432 @default.
• W4292450679 hasConcept C2780564577 @default.
• W4292450679 hasConcept C502942594 @default.
• W4292450679 hasConcept C54355233 @default.
• W4292450679 hasConcept C81885089 @default.
• W4292450679 hasConcept C86803240 @default.
• W4292450679 hasConcept C98274493 @default.
• W4292450679 hasConceptScore W4292450679C104317684 @default.
• W4292450679 hasConceptScore W4292450679C148738053 @default.
• W4292450679 hasConceptScore W4292450679C169760540 @default.
• W4292450679 hasConceptScore W4292450679C203014093 @default.
• W4292450679 hasConceptScore W4292450679C2776715637 @default.
• W4292450679 hasConceptScore W4292450679C2778496887 @default.
• W4292450679 hasConceptScore W4292450679C2778794669 @default.
• W4292450679 hasConceptScore W4292450679C2779083432 @default.
• W4292450679 hasConceptScore W4292450679C2780564577 @default.
• W4292450679 hasConceptScore W4292450679C502942594 @default.
• W4292450679 hasConceptScore W4292450679C54355233 @default.
• W4292450679 hasConceptScore W4292450679C81885089 @default.
• W4292450679 hasConceptScore W4292450679C86803240 @default.
• W4292450679 hasConceptScore W4292450679C98274493 @default.
• W4292450679 hasFunder F4320321001 @default.
• W4292450679 hasFunder F4320335787 @default.
• W4292450679 hasIssue "1" @default.
• W4292450679 hasLocation W42924506791 @default.
• W4292450679 hasLocation W42924506792 @default.
• W4292450679 hasLocation W42924506793 @default.
• W4292450679 hasOpenAccess W4292450679 @default.
• W4292450679 hasPrimaryLocation W42924506791 @default.
• W4292450679 hasRelatedWork W1993650910 @default.
• W4292450679 hasRelatedWork W2065298531 @default.
• W4292450679 hasRelatedWork W2094123535 @default.
• W4292450679 hasRelatedWork W2144209664 @default.
• W4292450679 hasRelatedWork W2418740007 @default.
• W4292450679 hasRelatedWork W2473182326 @default.
• W4292450679 hasRelatedWork W4294324472 @default.
• W4292450679 hasRelatedWork W4294733772 @default.
• W4292450679 hasRelatedWork W4321617536 @default.
• W4292450679 hasRelatedWork W61136835 @default.
• W4292450679 hasVolume "48" @default.
• W4292450679 isParatext "false" @default.
• W4292450679 isRetracted "false" @default.

• next