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- W4292466715 abstract "Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in the PKD1 or PKD2 gene which encodes membrane receptor PKD1 and cation channel PKD2, respectively. PKD2, also called transient receptor potential polycystin-2 (TRPP2), is a Ca 2+ -permeable channel located on the membrane of cell surface, primary cilia, and endoplasmic reticulum (ER). Ca 2+ is closely associated with diverse cellular functions. While ER Ca 2+ homeostasis depends on different Ca 2+ receptors, channels and transporters, the role of PKD2 within the ER remains controversial. Whether and how PKD2-mediated ER Ca 2+ leak relates to ADPKD pathogenesis is not well understood. Here, we reviewed current knowledge about the biophysical and physiological properties of PKD2 and how PKD2 contributes to ER Ca 2+ homeostasis." @default.
- W4292466715 created "2022-08-21" @default.
- W4292466715 creator A5063034566 @default.
- W4292466715 creator A5063059269 @default.
- W4292466715 creator A5075280684 @default.
- W4292466715 date "2022-08-10" @default.
- W4292466715 modified "2023-09-30" @default.
- W4292466715 title "Role of PKD2 in the endoplasmic reticulum calcium homeostasis" @default.
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- W4292466715 doi "https://doi.org/10.3389/fphys.2022.962571" @default.
- W4292466715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36035467" @default.
- W4292466715 hasPublicationYear "2022" @default.
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