Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292471382> ?p ?o ?g. }
- W4292471382 abstract "Abstract Herein, Imiquimod (IMQ) was incorporated in nanotransethosomes (nTES) to develop the IMQ-nTES nano-drug delivery system. IMQ-nTES was optimized using 2 3 factorial design. The optimized formulation was expressed with a particle size of 192.4 ± 1.60 nm, Poly-dispersibility of 0.115 ± 0.008, and IMQ percent entrapment efficiency of 91.05 ± 3.22%. Smooth and round morphology of IMQ-nTES vesicles was confirmed by TEM micrographs. Moreover, FTIR results have shown drug-excipient compatibility. The IMQ-nTES was laden inside the low molecular weight chitosan gel, which exhibited easy application, spreadability and no irritation to the applied skin. The release pattern has clearly exhibited improved dissolution properties of IMQ with the provision of the sustain release pattern. Higher IMQ content was deposited in deeper epidermis and dermis with IMQ-nTES gel, in contrast to ALDARA. In vivo, comparative toxicity study on BALB/c mice has shown significantly reduced (p < 0.001) psoriatic area severity index (PASI) score and less increment in ear thickness. Epidermal hyperplasia was an obvious finding with ALDARA which was, providentially, minimal in IMQ-nTES gel-treated skin. FTIR analysis of skin tissue has shown an enhancement of lipid and protein content in the ALDARA group, however, in the IMQ-nTES group no such change was observed. With ALDARA application, CD4 + T-cells and constitutive NF-κβ expression were significantly elevated, in comparison to the IMQ-nTES gel treated group. Moreover, the adequate expression of IFN-γ and cytotoxic CD8 + T-cells were suggesting the preserved IMQ efficacy with IMQ-nTES gel. Quantification of cutaneous as well as systemic inflammatory markers has also suggested the reduced psoriatic potential of IMQ-nTES gel. In essence, IMQ-nTES gel can be a suitable alternative to ALDARA owing to its better safety profile." @default.
- W4292471382 created "2022-08-21" @default.
- W4292471382 creator A5014693090 @default.
- W4292471382 creator A5027141069 @default.
- W4292471382 creator A5027857210 @default.
- W4292471382 creator A5033092225 @default.
- W4292471382 creator A5068895532 @default.
- W4292471382 creator A5079229090 @default.
- W4292471382 creator A5080508264 @default.
- W4292471382 date "2022-08-20" @default.
- W4292471382 modified "2023-10-09" @default.
- W4292471382 title "A cutback in Imiquimod cutaneous toxicity; comparative cutaneous toxicity analysis of Imiquimod nanotransethosomal gel with 5% marketed cream on the BALB/c mice" @default.
- W4292471382 cites W1543621601 @default.
- W4292471382 cites W1564553363 @default.
- W4292471382 cites W1740615695 @default.
- W4292471382 cites W1939997832 @default.
- W4292471382 cites W1958714784 @default.
- W4292471382 cites W1962929997 @default.
- W4292471382 cites W1972573592 @default.
- W4292471382 cites W1995821683 @default.
- W4292471382 cites W2001020866 @default.
- W4292471382 cites W2002109885 @default.
- W4292471382 cites W2004314683 @default.
- W4292471382 cites W2034587896 @default.
- W4292471382 cites W2035824519 @default.
- W4292471382 cites W2045065875 @default.
- W4292471382 cites W2047305468 @default.
- W4292471382 cites W2054230488 @default.
- W4292471382 cites W2063512593 @default.
- W4292471382 cites W2069976868 @default.
- W4292471382 cites W2077442778 @default.
- W4292471382 cites W2083274240 @default.
- W4292471382 cites W2089257120 @default.
- W4292471382 cites W2090484501 @default.
- W4292471382 cites W2091754459 @default.
- W4292471382 cites W2101957891 @default.
- W4292471382 cites W2108940045 @default.
- W4292471382 cites W2156414024 @default.
- W4292471382 cites W2158955637 @default.
- W4292471382 cites W2165720802 @default.
- W4292471382 cites W2207973369 @default.
- W4292471382 cites W2322645310 @default.
- W4292471382 cites W2344016019 @default.
- W4292471382 cites W2345226553 @default.
- W4292471382 cites W2378290597 @default.
- W4292471382 cites W2468627168 @default.
- W4292471382 cites W2489429174 @default.
- W4292471382 cites W2497709384 @default.
- W4292471382 cites W2498179686 @default.
- W4292471382 cites W2512397510 @default.
- W4292471382 cites W2564448292 @default.
- W4292471382 cites W2568301440 @default.
- W4292471382 cites W258735800 @default.
- W4292471382 cites W2592589512 @default.
- W4292471382 cites W2625114561 @default.
- W4292471382 cites W2735527928 @default.
- W4292471382 cites W2747751358 @default.
- W4292471382 cites W2750175360 @default.
- W4292471382 cites W2775663182 @default.
- W4292471382 cites W2778023441 @default.
- W4292471382 cites W2789408402 @default.
- W4292471382 cites W2795797914 @default.
- W4292471382 cites W2802561193 @default.
- W4292471382 cites W2802604307 @default.
- W4292471382 cites W2809299141 @default.
- W4292471382 cites W2884746924 @default.
- W4292471382 cites W2885791666 @default.
- W4292471382 cites W2891761389 @default.
- W4292471382 cites W2902373780 @default.
- W4292471382 cites W2913426265 @default.
- W4292471382 cites W2922428194 @default.
- W4292471382 cites W2953801032 @default.
- W4292471382 cites W2960093952 @default.
- W4292471382 cites W2976189387 @default.
- W4292471382 cites W2980574246 @default.
- W4292471382 cites W2998812277 @default.
- W4292471382 cites W2999994762 @default.
- W4292471382 cites W3004647787 @default.
- W4292471382 cites W3033524992 @default.
- W4292471382 cites W3076506164 @default.
- W4292471382 cites W3080894464 @default.
- W4292471382 cites W3083987393 @default.
- W4292471382 cites W3084617491 @default.
- W4292471382 cites W3088839394 @default.
- W4292471382 cites W3109450700 @default.
- W4292471382 cites W3122557039 @default.
- W4292471382 cites W3130362014 @default.
- W4292471382 cites W3131454261 @default.
- W4292471382 cites W3154504961 @default.
- W4292471382 cites W3155999531 @default.
- W4292471382 cites W3156021049 @default.
- W4292471382 cites W3158233760 @default.
- W4292471382 cites W3161949483 @default.
- W4292471382 cites W3180513403 @default.
- W4292471382 cites W3217223912 @default.
- W4292471382 cites W3217654606 @default.
- W4292471382 cites W38991183 @default.
- W4292471382 cites W411024725 @default.
- W4292471382 cites W4237159160 @default.
- W4292471382 cites W4282600730 @default.