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- W4292485114 abstract "A major obstacle to identifying improved treatments for pediatric low-grade brain tumors (gliomas) is the inability to reproducibly generate human xenografts. To surmount this barrier, we leveraged human induced pluripotent stem cell (hiPSC) engineering to generate low-grade gliomas (LGGs) harboring the two most common pediatric pilocytic astrocytoma-associated molecular alterations, NF1 loss and KIAA1549:BRAF fusion. Herein, we identified that hiPSC-derived neuroglial progenitor populations (neural progenitors, glial restricted progenitors and oligodendrocyte progenitors), but not terminally differentiated astrocytes, give rise to tumors retaining LGG histologic features for at least 6 months in vivo. Additionally, we demonstrated that hiPSC-LGG xenograft formation requires the absence of CD4 T cell-mediated induction of astrocytic Cxcl10 expression. Genetic Cxcl10 ablation is both necessary and sufficient for human LGG xenograft development, which additionally enables the successful long-term growth of patient-derived pediatric LGGs in vivo. Lastly, MEK inhibitor (PD0325901) treatment increased hiPSC-LGG cell apoptosis and reduced proliferation both in vitro and in vivo. Collectively, this study establishes a tractable experimental humanized platform to elucidate the pathogenesis of and potential therapeutic opportunities for childhood brain tumors." @default.
- W4292485114 created "2022-08-21" @default.
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- W4292485114 date "2022-08-19" @default.
- W4292485114 modified "2023-10-05" @default.
- W4292485114 title "Human induced pluripotent stem cell engineering establishes a humanized mouse platform for pediatric low-grade glioma modeling" @default.
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- W4292485114 cites W2050959218 @default.
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- W4292485114 doi "https://doi.org/10.1186/s40478-022-01428-2" @default.
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- W4292485114 hasPublicationYear "2022" @default.
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