FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292499229> ?p ?o ?g. }

• W4292499229 abstract "Abstract Background PI3K-Akt pathway activation and the expression of histone deacetylases (HDACs) are highly increased in esophageal cancer, suggesting that inhibition of such targets may be a viable therapeutic strategy. Herein, we aimed to evaluate the anti-tumor effect of CUDC-907, a dual PI3K-HDAC inhibitor, in esophageal squamous cell carcinoma (ESCC). Methods The anti-tumor effects of CUDC-907 in ESCC were evaluated using cell counting kit-8, flow cytometry, and western blot. mRNA-sequencing was used to explore the mechanism underlying CUDC-907 anti-tumor effects. The relations of reactive oxygen species (ROS), lipocalin 2 (LCN2), and CUDC-907 were determined by flow cytometry, rescue experiments, and western blot. The activation of the IRE1α-JNK-CHOP signal cascade was confirmed by western blot. The in vivo inhibitory effects of CUDC-907 were examined by a subcutaneous xenograft model in nude mice. Results CUDC-907 displayed effective inhibition in the proliferation, migration, and invasion of ESCC cells. Through an mRNA-sequencing and functional enrichment analysis, autophagy was found to be associated with cancer cells death. CUDC-907 not only inhibited the PI3K-Akt-mTOR pathways to result in autophagy, but also induced ROS accumulation to activate IRE1α-JNK-CHOP-mediated cytotoxic autophagy by downregulating LCN2 expression. Consistently, the in vivo anti-tumor effects of CUDC-907 accompanied by the downregulated expression of p-mTOR and LCN2 and upregulated expression of p-IRE1α and LC3B-II were evaluated in a xenograft mouse model. Conclusion Our findings suggested the clinical development and administration of CUDC-907 might act as a novel treatment strategy for ESCC. A more in-depth understanding of the anti-tumor effect of CUDC-907 in ESCC will benefit the clinically targeted treatment of ESCC." @default.
• W4292499229 created "2022-08-21" @default.
• W4292499229 creator A5002040719 @default.
• W4292499229 creator A5029695887 @default.
• W4292499229 creator A5033559805 @default.
• W4292499229 creator A5041699635 @default.
• W4292499229 creator A5060438882 @default.
• W4292499229 creator A5086146759 @default.
• W4292499229 creator A5089757436 @default.
• W4292499229 creator A5090539887 @default.
• W4292499229 date "2022-08-21" @default.
• W4292499229 modified "2023-10-18" @default.
• W4292499229 title "Anti-tumor effects of dual PI3K-HDAC inhibitor CUDC-907 on activation of ROS-IRE1α-JNK-mediated cytotoxic autophagy in esophageal cancer" @default.
• W4292499229 cites W1622029110 @default.
• W4292499229 cites W1963557715 @default.
• W4292499229 cites W1969524738 @default.
• W4292499229 cites W1972779889 @default.
• W4292499229 cites W1978974174 @default.
• W4292499229 cites W1991075835 @default.
• W4292499229 cites W2007437042 @default.
• W4292499229 cites W2014116656 @default.
• W4292499229 cites W2029679395 @default.
• W4292499229 cites W2106196422 @default.
• W4292499229 cites W2107661677 @default.
• W4292499229 cites W2159871803 @default.
• W4292499229 cites W2167992541 @default.
• W4292499229 cites W2192317544 @default.
• W4292499229 cites W2300908044 @default.
• W4292499229 cites W2332463535 @default.
• W4292499229 cites W2419447319 @default.
• W4292499229 cites W2548078838 @default.
• W4292499229 cites W2591872758 @default.
• W4292499229 cites W2608348693 @default.
• W4292499229 cites W2625470034 @default.
• W4292499229 cites W2747125926 @default.
• W4292499229 cites W2752305310 @default.
• W4292499229 cites W2807581530 @default.
• W4292499229 cites W2888898013 @default.
• W4292499229 cites W2891534244 @default.
• W4292499229 cites W2904591752 @default.
• W4292499229 cites W2907977380 @default.
• W4292499229 cites W2974310060 @default.
• W4292499229 cites W2988139673 @default.
• W4292499229 cites W2990124410 @default.
• W4292499229 cites W3003404611 @default.
• W4292499229 cites W3012640775 @default.
• W4292499229 cites W3013352992 @default.
• W4292499229 cites W3087509556 @default.
• W4292499229 cites W3092728279 @default.
• W4292499229 cites W3094746264 @default.
• W4292499229 cites W3119005666 @default.
• W4292499229 cites W3133295747 @default.
• W4292499229 cites W3152901913 @default.
• W4292499229 cites W3160336239 @default.
• W4292499229 cites W3166528212 @default.
• W4292499229 cites W3183713817 @default.
• W4292499229 cites W3187318779 @default.
• W4292499229 cites W3195935456 @default.
• W4292499229 cites W3202895962 @default.
• W4292499229 cites W3212425132 @default.
• W4292499229 cites W3215952199 @default.
• W4292499229 cites W4200407601 @default.
• W4292499229 cites W4212998302 @default.
• W4292499229 cites W4249441028 @default.
• W4292499229 cites W911344616 @default.
• W4292499229 doi "https://doi.org/10.1186/s13578-022-00855-x" @default.
• W4292499229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35989326" @default.
• W4292499229 hasPublicationYear "2022" @default.
• W4292499229 type Work @default.
• W4292499229 citedByCount "4" @default.
• W4292499229 countsByYear W42924992292023 @default.
• W4292499229 crossrefType "journal-article" @default.
• W4292499229 hasAuthorship W4292499229A5002040719 @default.
• W4292499229 hasAuthorship W4292499229A5029695887 @default.
• W4292499229 hasAuthorship W4292499229A5033559805 @default.
• W4292499229 hasAuthorship W4292499229A5041699635 @default.
• W4292499229 hasAuthorship W4292499229A5060438882 @default.
• W4292499229 hasAuthorship W4292499229A5086146759 @default.
• W4292499229 hasAuthorship W4292499229A5089757436 @default.
• W4292499229 hasAuthorship W4292499229A5090539887 @default.
• W4292499229 hasBestOaLocation W42924992291 @default.
• W4292499229 hasConcept C104317684 @default.
• W4292499229 hasConcept C190283241 @default.
• W4292499229 hasConcept C203014093 @default.
• W4292499229 hasConcept C203522944 @default.
• W4292499229 hasConcept C2776415932 @default.
• W4292499229 hasConcept C502942594 @default.
• W4292499229 hasConcept C553184892 @default.
• W4292499229 hasConcept C55493867 @default.
• W4292499229 hasConcept C62478195 @default.
• W4292499229 hasConcept C75217442 @default.
• W4292499229 hasConcept C86554907 @default.
• W4292499229 hasConcept C86803240 @default.
• W4292499229 hasConcept C95444343 @default.
• W4292499229 hasConceptScore W4292499229C104317684 @default.
• W4292499229 hasConceptScore W4292499229C190283241 @default.
• W4292499229 hasConceptScore W4292499229C203014093 @default.
• W4292499229 hasConceptScore W4292499229C203522944 @default.
• W4292499229 hasConceptScore W4292499229C2776415932 @default.
• W4292499229 hasConceptScore W4292499229C502942594 @default.

• next