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- W4292542361 endingPage "428" @default.
- W4292542361 startingPage "409" @default.
- W4292542361 abstract "Ischemic preconditioning (IP) is an innate phenomenon, triggered by brief, non-lethal cycles of ischemia/reperfusion applied to a tissue or organ that confers tolerance to a subsequent more prolonged ischemic event. Once started, it can reduce the severity of myocardial ischemia associated with some clinical situations, such as percutaneous coronary intervention (PCI) and intermittent aortic clamping during coronary artery bypass graft surgery (CABG). Although the mechanisms underlying IP have not been completely elucidated, several studies have shown that this phenomenon involves the participation of cell triggers, intracellular signaling pathways, and end-effectors. Understanding this mechanism enables the development of preconditioning mimetic agents. It is known that a range of medications that activate the signaling cascades at different cellular levels can interfere with both the stimulation and the blockade of IP. Investigations of signaling pathways underlying ischemic conditioning have identified a number of therapeutic targets for pharmacological manipulation. This review aims to present and discuss the effects of several medications on myocardial IP." @default.
- W4292542361 created "2022-08-22" @default.
- W4292542361 creator A5024436002 @default.
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- W4292542361 creator A5038775512 @default.
- W4292542361 creator A5059460659 @default.
- W4292542361 creator A5083286757 @default.
- W4292542361 date "2022-09-01" @default.
- W4292542361 modified "2023-10-01" @default.
- W4292542361 title "Protective or Inhibitory Effect of Pharmacological Therapy on Cardiac Ischemic Preconditioning: A Literature Review" @default.
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