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- W4292553471 abstract "Summary The difficulty of retrieving high-resolution, in vivo evidence of the proliferative- and migratory processes occurring in neural germinal zones has limited our understanding of neurodevelopmental mechanisms. Here, we employed a connectomic approach using a high-resolution, serial-sectioning scanning electron microscopy volume to investigate the laminar cytoarchitecture of the transient external granular layer (EGL) of the developing cerebellum, where granule cells coordinate a series of mitotic and migratory events. By integrating image segmentation, 3D reconstruction, and deep learning approaches, we discovered and characterized anatomically complex intercellular connections bridging pairs of cerebellar granule cells throughout the EGL. Connected cells were either mitotic, migratory, or transitioning between these two cell stages, displaying a chronological continuum of proliferative and migratory events never previously observed in vivo at this resolution. This unprecedented ultra-structural characterization poses intriguing hypotheses about intercellular connectivity between developing progenitors, and its possible role in the development of the central nervous system (CNS)." @default.
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- W4292553471 date "2022-08-21" @default.
- W4292553471 modified "2023-09-26" @default.
- W4292553471 title "3D reconstruction of the cerebellar germinal layer reveals intercytoplasmic connections between developing granule cells" @default.
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- W4292553471 doi "https://doi.org/10.1101/2022.08.21.504684" @default.
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