Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292553592> ?p ?o ?g. }
- W4292553592 abstract "The pathological T3N0M0 (pT3N0M0) rectal cancer is the earliest stage and has the best prognosis in the locally advanced rectal cancer, but the optimal treatment remains controversial. A reliable prognostic model is needed to discriminate the high-risk patients from the low-risk patients, and optimize adjuvant chemotherapy (ACT) treatment decisions by predicting the likelihood of ACT benefit for the target population.We gathered and analyzed 276 patients in Sun Yat-sen University Cancer Center from March 2005 to December 2011. All patients underwent total mesorectal excision (TME), without preoperative therapy, and were pathologically proven pT3N0M0 rectal cancer with negative circumferential resection margin (CRM). LASSO regression model was used for variable selection and risk factor prediction. Multivariable cox regression was used to develop the predicting model. Optimum cut-off values were determined using X-Tile plot analysis. The 10-fold cross-validation was adopted to validate the model. The performance of the nomogram was evaluated with its calibration, discrimination and clinical usefulness.A total of 188 patients (68.1%) had ACT and no patients had adjuvant radiotherapy. Age, monocyte percentage, carbohydrate antigen 19-9, lymph node dissection numbers and perineural invasion (PNI) were identified as significantly associated variables that could be combined for an accurate prediction risk of Cancer Specific Survival (CSS) for pT3N0M0 patients. The model adjusted for CSS showed good discrimination with a C-index of 0.723 (95% CI: 0.652-0.794). The calibration curves showed that the nomogram adjusted for CSS was able to predict 3-, 5-, and 10-year CSS accurately. The corresponding predicted probability was used to stratify high and low-risk patients (10-year CSS: 69.1% vs. 90.8%, HR = 3.815, 95%CI: 2.102-6.924, P < 0.0001). ACT improved overall survival (OS) in the low-risk patients (10-year OS: 91.9% vs. 83.3%, HR = 0.338, 95% CI: 0.135-0.848, P < 0.0001), while it did not exhibit a significant benefit in the high-risk patients.The present study showed that age, monocyte percentage, carbohydrate antigen 19-9, lymph node dissection numbers and PNI were independent prognostic factors for pT3N0M0 rectal cancer patients. A nomogram based on these prognostic factors effectively predicts CSS in patients, which can be conveniently used in clinical practice. ACT may improve overall survival in the low-risk patients. But the benefit of ACT was not seen in the high-risk patients." @default.
- W4292553592 created "2022-08-22" @default.
- W4292553592 creator A5000979147 @default.
- W4292553592 creator A5003645226 @default.
- W4292553592 creator A5038261359 @default.
- W4292553592 creator A5045550508 @default.
- W4292553592 creator A5058633305 @default.
- W4292553592 creator A5070478603 @default.
- W4292553592 creator A5087378995 @default.
- W4292553592 creator A5089120737 @default.
- W4292553592 date "2022-08-22" @default.
- W4292553592 modified "2023-09-30" @default.
- W4292553592 title "A nomogram for predicting 10-year cancer specific survival in patients with pathological T3N0M0 rectal cancer" @default.
- W4292553592 cites W1532654778 @default.
- W4292553592 cites W1732096386 @default.
- W4292553592 cites W1778696825 @default.
- W4292553592 cites W1915262341 @default.
- W4292553592 cites W1985213644 @default.
- W4292553592 cites W1987049028 @default.
- W4292553592 cites W1990423062 @default.
- W4292553592 cites W2013468153 @default.
- W4292553592 cites W2020478492 @default.
- W4292553592 cites W2034913961 @default.
- W4292553592 cites W2046774948 @default.
- W4292553592 cites W2048270768 @default.
- W4292553592 cites W2050260276 @default.
- W4292553592 cites W2072486718 @default.
- W4292553592 cites W2077241114 @default.
- W4292553592 cites W2079912968 @default.
- W4292553592 cites W2098916599 @default.
- W4292553592 cites W2116554142 @default.
- W4292553592 cites W2131204916 @default.
- W4292553592 cites W2133650808 @default.
- W4292553592 cites W2155492044 @default.
- W4292553592 cites W2159732195 @default.
- W4292553592 cites W2167684006 @default.
- W4292553592 cites W2168680994 @default.
- W4292553592 cites W2176362314 @default.
- W4292553592 cites W2406358661 @default.
- W4292553592 cites W2467657566 @default.
- W4292553592 cites W2597872842 @default.
- W4292553592 cites W2613221663 @default.
- W4292553592 cites W2617221589 @default.
- W4292553592 cites W2795718561 @default.
- W4292553592 cites W2906930533 @default.
- W4292553592 cites W2911291923 @default.
- W4292553592 cites W2950628641 @default.
- W4292553592 cites W2951173958 @default.
- W4292553592 cites W2954748261 @default.
- W4292553592 cites W2959534923 @default.
- W4292553592 cites W3005403657 @default.
- W4292553592 cites W3009485331 @default.
- W4292553592 cites W3009619051 @default.
- W4292553592 cites W3009782965 @default.
- W4292553592 cites W3009835802 @default.
- W4292553592 cites W3039259060 @default.
- W4292553592 cites W3046750712 @default.
- W4292553592 cites W3087225074 @default.
- W4292553592 cites W3100840114 @default.
- W4292553592 cites W3120493905 @default.
- W4292553592 cites W4281738617 @default.
- W4292553592 cites W841382446 @default.
- W4292553592 doi "https://doi.org/10.3389/fmed.2022.977652" @default.
- W4292553592 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36072948" @default.
- W4292553592 hasPublicationYear "2022" @default.
- W4292553592 type Work @default.
- W4292553592 citedByCount "0" @default.
- W4292553592 crossrefType "journal-article" @default.
- W4292553592 hasAuthorship W4292553592A5000979147 @default.
- W4292553592 hasAuthorship W4292553592A5003645226 @default.
- W4292553592 hasAuthorship W4292553592A5038261359 @default.
- W4292553592 hasAuthorship W4292553592A5045550508 @default.
- W4292553592 hasAuthorship W4292553592A5058633305 @default.
- W4292553592 hasAuthorship W4292553592A5070478603 @default.
- W4292553592 hasAuthorship W4292553592A5087378995 @default.
- W4292553592 hasAuthorship W4292553592A5089120737 @default.
- W4292553592 hasBestOaLocation W42925535921 @default.
- W4292553592 hasConcept C121608353 @default.
- W4292553592 hasConcept C126322002 @default.
- W4292553592 hasConcept C141071460 @default.
- W4292553592 hasConcept C143998085 @default.
- W4292553592 hasConcept C2777154038 @default.
- W4292553592 hasConcept C34626388 @default.
- W4292553592 hasConcept C50382708 @default.
- W4292553592 hasConcept C526805850 @default.
- W4292553592 hasConcept C71924100 @default.
- W4292553592 hasConceptScore W4292553592C121608353 @default.
- W4292553592 hasConceptScore W4292553592C126322002 @default.
- W4292553592 hasConceptScore W4292553592C141071460 @default.
- W4292553592 hasConceptScore W4292553592C143998085 @default.
- W4292553592 hasConceptScore W4292553592C2777154038 @default.
- W4292553592 hasConceptScore W4292553592C34626388 @default.
- W4292553592 hasConceptScore W4292553592C50382708 @default.
- W4292553592 hasConceptScore W4292553592C526805850 @default.
- W4292553592 hasConceptScore W4292553592C71924100 @default.
- W4292553592 hasLocation W42925535921 @default.
- W4292553592 hasLocation W42925535922 @default.
- W4292553592 hasLocation W42925535923 @default.
- W4292553592 hasLocation W42925535924 @default.
- W4292553592 hasOpenAccess W4292553592 @default.