FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292559826> ?p ?o ?g. }

• W4292559826 abstract "The death of spinal motor neurons (SMNs) after spinal cord injury (SCI) is a crucial cause, contributing to a permanent neurological deficit. Total flavonoids of hawthorn leaves (TFHL) have been confirmed to have potentially therapeutic for SCI. Nonetheless, the roles and mechanisms of TFHL in recovering neuromotor function and regenerating axons of SMNs have not been fully elucidated. In this study, TFHL was applied to treat rats with SCI and injured SMNs for 7 days. In vivo experiment, rats with SCI were evaluated by a BBB (Basso-Beattie-Bresnahan) score to assess their motor functional recovery. The morphology, microstructure, apoptosis, Nissl bodies, and autophagy of SMNs in spinal cord tissue were detected by Hematoxylin-eosin (HE) staining, transmission electron microscopy, TUNEL staining, Nissl staining, and immunohistochemistry respectively. In vitro experiment, the co-culture model of SMNs and astrocytes was constructed to simulate the internal environment around SMNs in the spinal cord tissue. The cell morphology, microstructure, axonal regeneration, and autophagy were observed via optical microscope, transmission electron microscopy, and immunofluorescence. The content of neurotrophic factors in the cell culture medium of the co-culture model was detected by ELISA. Moreover, the expression of axon-related and autophagy-related proteins in the spinal cord tissue and SMNs was measured by Western Blot. We demonstrated that TFHL improved the neuromotor function recovery in rats after SCI. We then found that TFHL significantly promoted injured spinal cord tissue repair, reduced apoptosis, and improved the functional status of neurons in spinal cord tissue in vivo. Meanwhile, the cell morphology, microstructure, and axonal regeneration of damaged SMNs also obviously were improved, and the secretion of neurotrophic factors was facilitated after treatment with TFHL in vitro. Further, we revealed that TFHL promoted autophagy and related protein expression in vivo and vitro. Taken together, our study suggested that TFHL might facilitate autophagy and have neuroprotective properties in SMNs to enhance the recovery of neuromotor function of rats with SCI." @default.
• W4292559826 created "2022-08-22" @default.
• W4292559826 creator A5008007459 @default.
• W4292559826 creator A5010064618 @default.
• W4292559826 creator A5025602649 @default.
• W4292559826 creator A5056002024 @default.
• W4292559826 creator A5060640583 @default.
• W4292559826 creator A5063917352 @default.
• W4292559826 creator A5080286294 @default.
• W4292559826 creator A5084787098 @default.
• W4292559826 date "2022-08-22" @default.
• W4292559826 modified "2023-09-26" @default.
• W4292559826 title "Total flavonoids of hawthorn leaves protect spinal motor neurons via promotion of autophagy after spinal cord injury" @default.
• W4292559826 cites W1524705340 @default.
• W4292559826 cites W1998116758 @default.
• W4292559826 cites W2042899565 @default.
• W4292559826 cites W2044885291 @default.
• W4292559826 cites W2045528880 @default.
• W4292559826 cites W2060812361 @default.
• W4292559826 cites W2085864993 @default.
• W4292559826 cites W2168367599 @default.
• W4292559826 cites W2170645579 @default.
• W4292559826 cites W2281491717 @default.
• W4292559826 cites W2340786874 @default.
• W4292559826 cites W2528095620 @default.
• W4292559826 cites W2562536400 @default.
• W4292559826 cites W2590181299 @default.
• W4292559826 cites W2621605545 @default.
• W4292559826 cites W2744579607 @default.
• W4292559826 cites W2753211497 @default.
• W4292559826 cites W2765463353 @default.
• W4292559826 cites W2767312268 @default.
• W4292559826 cites W2807183210 @default.
• W4292559826 cites W2893982904 @default.
• W4292559826 cites W2909477364 @default.
• W4292559826 cites W2937346106 @default.
• W4292559826 cites W2944132366 @default.
• W4292559826 cites W2955893995 @default.
• W4292559826 cites W2963539474 @default.
• W4292559826 cites W2983855478 @default.
• W4292559826 cites W2999218949 @default.
• W4292559826 cites W3005174885 @default.
• W4292559826 cites W3008307280 @default.
• W4292559826 cites W3015905428 @default.
• W4292559826 cites W3018128871 @default.
• W4292559826 cites W3024325692 @default.
• W4292559826 cites W3042093224 @default.
• W4292559826 cites W3049431618 @default.
• W4292559826 cites W3080680156 @default.
• W4292559826 cites W3089352106 @default.
• W4292559826 cites W3093434759 @default.
• W4292559826 cites W3118795066 @default.
• W4292559826 cites W3124756354 @default.
• W4292559826 cites W3138545758 @default.
• W4292559826 cites W3157652072 @default.
• W4292559826 cites W3161170658 @default.
• W4292559826 cites W3189693479 @default.
• W4292559826 cites W3193365448 @default.
• W4292559826 cites W3193952537 @default.
• W4292559826 cites W3209018839 @default.
• W4292559826 cites W4200422903 @default.
• W4292559826 doi "https://doi.org/10.3389/fphar.2022.925568" @default.
• W4292559826 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36071834" @default.
• W4292559826 hasPublicationYear "2022" @default.
• W4292559826 type Work @default.
• W4292559826 citedByCount "1" @default.
• W4292559826 countsByYear W42925598262023 @default.
• W4292559826 crossrefType "journal-article" @default.
• W4292559826 hasAuthorship W4292559826A5008007459 @default.
• W4292559826 hasAuthorship W4292559826A5010064618 @default.
• W4292559826 hasAuthorship W4292559826A5025602649 @default.
• W4292559826 hasAuthorship W4292559826A5056002024 @default.
• W4292559826 hasAuthorship W4292559826A5060640583 @default.
• W4292559826 hasAuthorship W4292559826A5063917352 @default.
• W4292559826 hasAuthorship W4292559826A5080286294 @default.
• W4292559826 hasAuthorship W4292559826A5084787098 @default.
• W4292559826 hasBestOaLocation W42925598261 @default.
• W4292559826 hasConcept C105702510 @default.
• W4292559826 hasConcept C142724271 @default.
• W4292559826 hasConcept C169760540 @default.
• W4292559826 hasConcept C190283241 @default.
• W4292559826 hasConcept C203522944 @default.
• W4292559826 hasConcept C2776752467 @default.
• W4292559826 hasConcept C2778334475 @default.
• W4292559826 hasConcept C2780775167 @default.
• W4292559826 hasConcept C31573885 @default.
• W4292559826 hasConcept C37753355 @default.
• W4292559826 hasConcept C55493867 @default.
• W4292559826 hasConcept C71924100 @default.
• W4292559826 hasConcept C74864618 @default.
• W4292559826 hasConcept C86803240 @default.
• W4292559826 hasConcept C95444343 @default.
• W4292559826 hasConceptScore W4292559826C105702510 @default.
• W4292559826 hasConceptScore W4292559826C142724271 @default.
• W4292559826 hasConceptScore W4292559826C169760540 @default.
• W4292559826 hasConceptScore W4292559826C190283241 @default.
• W4292559826 hasConceptScore W4292559826C203522944 @default.
• W4292559826 hasConceptScore W4292559826C2776752467 @default.
• W4292559826 hasConceptScore W4292559826C2778334475 @default.
• W4292559826 hasConceptScore W4292559826C2780775167 @default.

• next