Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292574085> ?p ?o ?g. }
- W4292574085 abstract "Background HIV persistence during antiretroviral therapy (ART) is the principal obstacle to cure. Lymphoid tissue is a compartment for HIV, but mechanisms of persistence during ART and viral rebound when ART is interrupted are inadequately understood. Metabolic activity in lymphoid tissue of patients on long-term ART is relatively low, and increases when ART is stopped. Increases in metabolic activity can be detected by 18 F-fluorodeoxyglucose Positron Emission Tomography (FDG-PET) and may represent sites of HIV replication or immune activation in response to HIV replication. Methods FDG-PET imaging will be used to identify areas of high and low metabolic uptake in lymphoid tissue of individuals undergoing long-term ART. Baseline tissue samples will be collected. Participants will then be randomized 1:1 to continue or interrupt ART via analytic treatment interruption (ATI). Image-guided biopsy will be repeated 10 days after ATI initiation. After ART restart criteria are met, image-guided biopsy will be repeated once viral suppression is re-achieved. Participants who continued ART will have a second FDG-PET and biopsies 12–16 weeks after the first. Genetic characteristics of HIV populations in areas of high and low FDG uptake will be assesed. Optional assessments of non-lymphoid anatomic compartments may be performed to evaluate HIV populations in distinct anatomic compartments. Anticipated results We anticipate that PET standardized uptake values (SUV) will correlate with HIV viral RNA in biopsies of those regions and that lymph nodes with high SUV will have more viral RNA than those with low SUV within a patient. Individuals who undergo ATI are expected to have diverse viral populations upon viral rebound in lymphoid tissue. HIV populations in tissues may initially be phylogenetically diverse after ATI, with emergence of dominant viral species (clone) over time in plasma. Dominant viral species may represent the same HIV population seen before ATI. Discussion This study will allow us to explore utility of PET for identification of HIV infected cells and determine whether high FDG uptake respresents areas of HIV replication, immune activation or both. We will also characterize HIV infected cell populations in different anatomic locations. The protocol will represent a platform to investigate persistence and agents that may target HIV populations. Study protocol registration Identifier: NCT05419024." @default.
- W4292574085 created "2022-08-22" @default.
- W4292574085 creator A5000097172 @default.
- W4292574085 creator A5000335170 @default.
- W4292574085 creator A5005114471 @default.
- W4292574085 creator A5006307543 @default.
- W4292574085 creator A5009477138 @default.
- W4292574085 creator A5010503150 @default.
- W4292574085 creator A5017891860 @default.
- W4292574085 creator A5020491291 @default.
- W4292574085 creator A5026128828 @default.
- W4292574085 creator A5026470145 @default.
- W4292574085 creator A5026594704 @default.
- W4292574085 creator A5028059374 @default.
- W4292574085 creator A5034128963 @default.
- W4292574085 creator A5038057527 @default.
- W4292574085 creator A5044249775 @default.
- W4292574085 creator A5058691136 @default.
- W4292574085 creator A5061093871 @default.
- W4292574085 creator A5064867855 @default.
- W4292574085 creator A5076255550 @default.
- W4292574085 creator A5082703920 @default.
- W4292574085 creator A5085630104 @default.
- W4292574085 date "2022-08-22" @default.
- W4292574085 modified "2023-10-11" @default.
- W4292574085 title "Imaging and biopsy of HIV-infected individuals undergoing analytic treatment interruption" @default.
- W4292574085 cites W1497170016 @default.
- W4292574085 cites W1700981343 @default.
- W4292574085 cites W1899998931 @default.
- W4292574085 cites W1971331125 @default.
- W4292574085 cites W1976111750 @default.
- W4292574085 cites W1978406880 @default.
- W4292574085 cites W1979000541 @default.
- W4292574085 cites W1979344038 @default.
- W4292574085 cites W1989825814 @default.
- W4292574085 cites W1997386233 @default.
- W4292574085 cites W1998994059 @default.
- W4292574085 cites W2005991279 @default.
- W4292574085 cites W2011626958 @default.
- W4292574085 cites W2012437716 @default.
- W4292574085 cites W2013315610 @default.
- W4292574085 cites W2015228918 @default.
- W4292574085 cites W2023469490 @default.
- W4292574085 cites W2030844138 @default.
- W4292574085 cites W2036572839 @default.
- W4292574085 cites W2038474674 @default.
- W4292574085 cites W2056833651 @default.
- W4292574085 cites W2069574917 @default.
- W4292574085 cites W2070959267 @default.
- W4292574085 cites W2071631843 @default.
- W4292574085 cites W2072620561 @default.
- W4292574085 cites W2075401994 @default.
- W4292574085 cites W2088783247 @default.
- W4292574085 cites W2093441624 @default.
- W4292574085 cites W2095683811 @default.
- W4292574085 cites W2125075911 @default.
- W4292574085 cites W2127012498 @default.
- W4292574085 cites W2136043926 @default.
- W4292574085 cites W2139217795 @default.
- W4292574085 cites W2141561961 @default.
- W4292574085 cites W2145125949 @default.
- W4292574085 cites W2145266626 @default.
- W4292574085 cites W2151758275 @default.
- W4292574085 cites W2158564605 @default.
- W4292574085 cites W2162498382 @default.
- W4292574085 cites W2163515030 @default.
- W4292574085 cites W2187666247 @default.
- W4292574085 cites W2264411206 @default.
- W4292574085 cites W2272142554 @default.
- W4292574085 cites W2329122269 @default.
- W4292574085 cites W2401325207 @default.
- W4292574085 cites W2406049093 @default.
- W4292574085 cites W2468631541 @default.
- W4292574085 cites W2473595575 @default.
- W4292574085 cites W2528211551 @default.
- W4292574085 cites W2557191642 @default.
- W4292574085 cites W2579096052 @default.
- W4292574085 cites W2782685227 @default.
- W4292574085 cites W2793402562 @default.
- W4292574085 cites W2820991405 @default.
- W4292574085 cites W2884947610 @default.
- W4292574085 cites W2891693365 @default.
- W4292574085 cites W2892871408 @default.
- W4292574085 cites W2896724624 @default.
- W4292574085 cites W2902316253 @default.
- W4292574085 cites W2911228036 @default.
- W4292574085 cites W2917405435 @default.
- W4292574085 cites W2921307991 @default.
- W4292574085 cites W2921747626 @default.
- W4292574085 cites W2922618739 @default.
- W4292574085 cites W2924717068 @default.
- W4292574085 cites W2938880203 @default.
- W4292574085 cites W2942485869 @default.
- W4292574085 cites W2964495532 @default.
- W4292574085 cites W2964788379 @default.
- W4292574085 cites W2973153742 @default.
- W4292574085 cites W2986940440 @default.
- W4292574085 cites W2998907312 @default.
- W4292574085 cites W3004820006 @default.
- W4292574085 cites W3016186788 @default.