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- W4292590690 abstract "Affecting 60% of the people diagnosed with dementia, Alzheimer’s disease is a neurodegenerative pathology that negatively impacts the cognitive function. It is characterised by symptoms as memory loss, locomotor difficulties, behavioural changes, and even rationalization issues. This disease has been studied on both rodents and fishes. Rodents helped science people establish the basic neurobiology of dementia, while fishes (Danio rerio – the zebra fish, especially) were more appropriate as transgenic models. Recent studies proved that transgenically induced Alzheimer’s disease at zebra fishes is not defined only by cognitive decline but also by motor function disorders. Objectives. This study aims to analyse how iron chloride and sucrose impact zebra fishes’ locomotion and memory by using the T maze. Methods. 50 zebra fishes were purchased from a local pisciculturist and randomly divided in 4 experimental groups. They were accommodated in the Ecotoxicology laboratory at “Alexandru Ioan Cuza” University for 3 weeks according to the European Union Commission and European Union Council recommendations regarding experimental purposes animals' protection and accommodation. Fishes’ possible behavioural changes were analysed after they were given sucrose and iron chloride separately and in their combination. Results. We observed that sucrose administration negatively impacted the locomotory activity while iron chloride surprisingly increased it. The possible explanation is the fact that iron chloride generated anxiety - an early-stage Alzheimer's disease symptom, and therefore improved fishes' swimming performance. Successive sucrose and iron chloride administration also led to increased locomotor activity." @default.
- W4292590690 created "2022-08-22" @default.
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- W4292590690 date "2021-01-01" @default.
- W4292590690 modified "2023-10-07" @default.
- W4292590690 title "Behavioural and Metabolical Changes Associated with the Pathophysiology of Alzheimer’s Disease in Zebrafish" @default.
- W4292590690 doi "https://doi.org/10.56082/annalsarscibio.2021.2.66" @default.
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