Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292595966> ?p ?o ?g. }
- W4292595966 endingPage "1830" @default.
- W4292595966 startingPage "1817" @default.
- W4292595966 abstract "ABSTRACT Background The deposition of α‐synuclein (α‐Syn) in the brain is the pathological hallmark of Parkinson's disease (PD). Epidemiological data indicate that exposure to fine particulate matter (≤2.5 μm in aerodynamic diameter [PM2.5]) is associated with an increased risk for PD. Objective The aim of this study is to investigate whether PM2.5 has a direct effect on α‐Syn pathology and how it drives the risk for PD. Methods PM2.5 was added into α‐Syn monomers and different cell models to test whether PM2.5 can promote the fibrillization and aggregation of α‐Syn. α‐Syn A53T transgenic mice and α‐Syn knockout mice were used to investigate the effects of PM2.5 on PD‐like pathology. Results PM2.5 triggers the fibrillization of α‐Syn and promotes the formation of α‐Syn fibrils with enhanced seeding activity and neurotoxicity. PM2.5 also induces mitochondrial dysfunction and oxidative stress. Intrastriatal injection or intranasal administration of PM2.5 exacerbates α‐Syn pathology and dopaminergic neuronal degeneration in α‐Syn A53T transgenic mice. The detrimental effect of PM2.5 was attenuated in α‐Syn knockout mice. Conclusions Our results identify that PM2.5 exposure could promote the α‐Syn pathology, providing mechanistic insights into how PM2.5 increases the risk for PD. © 2022 International Parkinson and Movement Disorder Society." @default.
- W4292595966 created "2022-08-22" @default.
- W4292595966 creator A5005775682 @default.
- W4292595966 creator A5016712790 @default.
- W4292595966 creator A5022153485 @default.
- W4292595966 creator A5029314429 @default.
- W4292595966 creator A5033777424 @default.
- W4292595966 creator A5043197762 @default.
- W4292595966 creator A5047709452 @default.
- W4292595966 creator A5052710748 @default.
- W4292595966 creator A5072809551 @default.
- W4292595966 creator A5073266870 @default.
- W4292595966 creator A5074607649 @default.
- W4292595966 creator A5080846142 @default.
- W4292595966 creator A5082285758 @default.
- W4292595966 creator A5088657051 @default.
- W4292595966 date "2022-08-22" @default.
- W4292595966 modified "2023-10-15" @default.
- W4292595966 title "Fine Particulate Matter Triggers α‐Synuclein Fibrillization and Parkinson‐like Neurodegeneration" @default.
- W4292595966 cites W2073449985 @default.
- W4292595966 cites W2081966615 @default.
- W4292595966 cites W2094288240 @default.
- W4292595966 cites W2128903550 @default.
- W4292595966 cites W2797369529 @default.
- W4292595966 cites W2802062315 @default.
- W4292595966 cites W2806503756 @default.
- W4292595966 cites W2808931321 @default.
- W4292595966 cites W2810451232 @default.
- W4292595966 cites W2901162259 @default.
- W4292595966 cites W291729710 @default.
- W4292595966 cites W2933754837 @default.
- W4292595966 cites W2947873105 @default.
- W4292595966 cites W2953112487 @default.
- W4292595966 cites W2969573657 @default.
- W4292595966 cites W3001336685 @default.
- W4292595966 cites W3005252823 @default.
- W4292595966 cites W3011755495 @default.
- W4292595966 cites W3023667110 @default.
- W4292595966 cites W3025767865 @default.
- W4292595966 cites W3027900078 @default.
- W4292595966 cites W3031912651 @default.
- W4292595966 cites W3082264965 @default.
- W4292595966 cites W3090493792 @default.
- W4292595966 cites W3093459267 @default.
- W4292595966 cites W3127979955 @default.
- W4292595966 cites W3135340356 @default.
- W4292595966 cites W3150238284 @default.
- W4292595966 cites W3160389978 @default.
- W4292595966 cites W3162257559 @default.
- W4292595966 cites W3174220639 @default.
- W4292595966 cites W3179839425 @default.
- W4292595966 cites W3199724439 @default.
- W4292595966 cites W3207879740 @default.
- W4292595966 cites W3210500184 @default.
- W4292595966 cites W3211255519 @default.
- W4292595966 doi "https://doi.org/10.1002/mds.29181" @default.
- W4292595966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36054165" @default.
- W4292595966 hasPublicationYear "2022" @default.
- W4292595966 type Work @default.
- W4292595966 citedByCount "7" @default.
- W4292595966 countsByYear W42925959662023 @default.
- W4292595966 crossrefType "journal-article" @default.
- W4292595966 hasAuthorship W4292595966A5005775682 @default.
- W4292595966 hasAuthorship W4292595966A5016712790 @default.
- W4292595966 hasAuthorship W4292595966A5022153485 @default.
- W4292595966 hasAuthorship W4292595966A5029314429 @default.
- W4292595966 hasAuthorship W4292595966A5033777424 @default.
- W4292595966 hasAuthorship W4292595966A5043197762 @default.
- W4292595966 hasAuthorship W4292595966A5047709452 @default.
- W4292595966 hasAuthorship W4292595966A5052710748 @default.
- W4292595966 hasAuthorship W4292595966A5072809551 @default.
- W4292595966 hasAuthorship W4292595966A5073266870 @default.
- W4292595966 hasAuthorship W4292595966A5074607649 @default.
- W4292595966 hasAuthorship W4292595966A5080846142 @default.
- W4292595966 hasAuthorship W4292595966A5082285758 @default.
- W4292595966 hasAuthorship W4292595966A5088657051 @default.
- W4292595966 hasConcept C102230213 @default.
- W4292595966 hasConcept C104317684 @default.
- W4292595966 hasConcept C126322002 @default.
- W4292595966 hasConcept C134018914 @default.
- W4292595966 hasConcept C137183658 @default.
- W4292595966 hasConcept C141035611 @default.
- W4292595966 hasConcept C142724271 @default.
- W4292595966 hasConcept C169760540 @default.
- W4292595966 hasConcept C170493617 @default.
- W4292595966 hasConcept C182704531 @default.
- W4292595966 hasConcept C185592680 @default.
- W4292595966 hasConcept C25498285 @default.
- W4292595966 hasConcept C2776151105 @default.
- W4292595966 hasConcept C2776925932 @default.
- W4292595966 hasConcept C2779134260 @default.
- W4292595966 hasConcept C2779491297 @default.
- W4292595966 hasConcept C2779734285 @default.
- W4292595966 hasConcept C29730261 @default.
- W4292595966 hasConcept C513476851 @default.
- W4292595966 hasConcept C55493867 @default.
- W4292595966 hasConcept C71924100 @default.
- W4292595966 hasConcept C86803240 @default.