FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292603724> ?p ?o ?g. }

• W4292603724 abstract "Abstract Background Postoperative delirium (POD) is a critical complication in patients accepting colon carcinoma surgery. Neostigmine, as a cholinesterase inhibitor, can enhance the transmission of cholinergic transmitters in synaptic space, and play an important role in maintaining the normal level of cognition, attention and consciousness. The objective of this study was to investigate the effect of neostigmine on POD and clinical prognosis. Methods A randomized, double-blind controlled trial was implemented in Qingdao Municipal Hospital Affiliated to Qingdao University. A total of 454 patients aged 40 to 90 years old accepted colon carcinoma surgery were enrolled between June 7, 2020, and June 7, 2021, with final follow-up on December 8, 2021. Patients were randomly assigned to two groups: the neostigmine group (group N) and the placebo group (group P), the patients in group N were injected with 0.04 mg/kg neostigmine and 0.02 mg/kg atropine intravenously. The primary endpoint was the incidence of POD, researchers evaluated the occurrence of POD by the Confusion Assessment Method (CAM) twice daily (at 10 a.m. and 2 p.m.) during the first 7 postoperative days, POD severity was assessed by the Memorial Delirium Assessment Scale (MDAS). The secondary endpoints were the extubating time, postanesthesia care unit (PACU) time, the incidence of various postoperative complications, length of hospital stays, and 6 months postoperative mortality. Results The incidence of POD was 20.20% (81/401), including 19.39% (38/196) in group N and 20.98% (43/205) in group P. There was no significant statistical significance in the incidence of POD between group N and group P ( P > 0.05); Compared to group P, the extubating time and PACU time in group N were significantly reduced ( P < 0.001), the incidence of postoperative pulmonary complications (POPCs) decreased significantly in group N ( P < 0.05), while no significant differences were observed in postoperative hospital stay and mortality in 6 months between the two groups ( P > 0.05). Conclusion For patients accepted colon carcinoma surgery, neostigmine did not significantly reduce the incidence of POD, postoperative mortality and postoperative hospital stay, while it indeed reduced the extubating time, PACU time and the incidence of POPCs. Trial registration The randomized, double-blind, controlled trial was registered retrospectively at www.chictr.org.cn on 07/06/2020 (ChiCTR2000033639)." @default.
• W4292603724 created "2022-08-22" @default.
• W4292603724 creator A5005261215 @default.
• W4292603724 creator A5014560245 @default.
• W4292603724 creator A5018507990 @default.
• W4292603724 creator A5018703835 @default.
• W4292603724 creator A5033732336 @default.
• W4292603724 creator A5040961908 @default.
• W4292603724 creator A5081105290 @default.
• W4292603724 creator A5081195640 @default.
• W4292603724 date "2022-08-22" @default.
• W4292603724 modified "2023-10-06" @default.
• W4292603724 title "The effect of neostigmine on postoperative delirium after colon carcinoma surgery: a randomized, double-blind, controlled trial" @default.
• W4292603724 cites W1963778325 @default.
• W4292603724 cites W1966208007 @default.
• W4292603724 cites W1968820763 @default.
• W4292603724 cites W1985452079 @default.
• W4292603724 cites W1999831583 @default.
• W4292603724 cites W2003814194 @default.
• W4292603724 cites W2028954154 @default.
• W4292603724 cites W2061403265 @default.
• W4292603724 cites W2069368135 @default.
• W4292603724 cites W2086149339 @default.
• W4292603724 cites W2087972467 @default.
• W4292603724 cites W2098999434 @default.
• W4292603724 cites W2105995566 @default.
• W4292603724 cites W2111315178 @default.
• W4292603724 cites W2120789653 @default.
• W4292603724 cites W2129690840 @default.
• W4292603724 cites W2132695086 @default.
• W4292603724 cites W2140190457 @default.
• W4292603724 cites W2144457047 @default.
• W4292603724 cites W2151989011 @default.
• W4292603724 cites W2167848412 @default.
• W4292603724 cites W2168157935 @default.
• W4292603724 cites W2344565087 @default.
• W4292603724 cites W2469994275 @default.
• W4292603724 cites W2492722401 @default.
• W4292603724 cites W2573351958 @default.
• W4292603724 cites W2586426771 @default.
• W4292603724 cites W2766396702 @default.
• W4292603724 cites W2768845207 @default.
• W4292603724 cites W2900441263 @default.
• W4292603724 cites W2912239957 @default.
• W4292603724 cites W2997566832 @default.
• W4292603724 cites W3004873902 @default.
• W4292603724 cites W33157334 @default.
• W4292603724 cites W4211189332 @default.
• W4292603724 doi "https://doi.org/10.1186/s12871-022-01804-4" @default.
• W4292603724 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35996073" @default.
• W4292603724 hasPublicationYear "2022" @default.
• W4292603724 type Work @default.
• W4292603724 citedByCount "1" @default.
• W4292603724 countsByYear W42926037242023 @default.
• W4292603724 crossrefType "journal-article" @default.
• W4292603724 hasAuthorship W4292603724A5005261215 @default.
• W4292603724 hasAuthorship W4292603724A5014560245 @default.
• W4292603724 hasAuthorship W4292603724A5018507990 @default.
• W4292603724 hasAuthorship W4292603724A5018703835 @default.
• W4292603724 hasAuthorship W4292603724A5033732336 @default.
• W4292603724 hasAuthorship W4292603724A5040961908 @default.
• W4292603724 hasAuthorship W4292603724A5081105290 @default.
• W4292603724 hasAuthorship W4292603724A5081195640 @default.
• W4292603724 hasBestOaLocation W42926037241 @default.
• W4292603724 hasConcept C120665830 @default.
• W4292603724 hasConcept C121332964 @default.
• W4292603724 hasConcept C141071460 @default.
• W4292603724 hasConcept C142724271 @default.
• W4292603724 hasConcept C168563851 @default.
• W4292603724 hasConcept C177713679 @default.
• W4292603724 hasConcept C204787440 @default.
• W4292603724 hasConcept C27081682 @default.
• W4292603724 hasConcept C2777411258 @default.
• W4292603724 hasConcept C2779526319 @default.
• W4292603724 hasConcept C2779753318 @default.
• W4292603724 hasConcept C2780651394 @default.
• W4292603724 hasConcept C2781453256 @default.
• W4292603724 hasConcept C31174226 @default.
• W4292603724 hasConcept C42219234 @default.
• W4292603724 hasConcept C61511704 @default.
• W4292603724 hasConcept C71924100 @default.
• W4292603724 hasConceptScore W4292603724C120665830 @default.
• W4292603724 hasConceptScore W4292603724C121332964 @default.
• W4292603724 hasConceptScore W4292603724C141071460 @default.
• W4292603724 hasConceptScore W4292603724C142724271 @default.
• W4292603724 hasConceptScore W4292603724C168563851 @default.
• W4292603724 hasConceptScore W4292603724C177713679 @default.
• W4292603724 hasConceptScore W4292603724C204787440 @default.
• W4292603724 hasConceptScore W4292603724C27081682 @default.
• W4292603724 hasConceptScore W4292603724C2777411258 @default.
• W4292603724 hasConceptScore W4292603724C2779526319 @default.
• W4292603724 hasConceptScore W4292603724C2779753318 @default.
• W4292603724 hasConceptScore W4292603724C2780651394 @default.
• W4292603724 hasConceptScore W4292603724C2781453256 @default.
• W4292603724 hasConceptScore W4292603724C31174226 @default.
• W4292603724 hasConceptScore W4292603724C42219234 @default.
• W4292603724 hasConceptScore W4292603724C61511704 @default.
• W4292603724 hasConceptScore W4292603724C71924100 @default.
• W4292603724 hasIssue "1" @default.
• W4292603724 hasLocation W42926037241 @default.

• next