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• W4292608138 abstract "Abstract RNA viruses have high mutation rates, with the majority of mutations being deleterious. We examine patterns of deleterious mutation accumulation over multiple rounds of viral replication, with a focus on how cellular coinfection and heterogeneity in viral output affect these patterns. Specifically, using agent-based intercellular simulations we find, in agreement with previous studies, that coinfection of cells by viruses relaxes the strength of purifying selection and thereby increases the rate of deleterious mutation accumulation. We further find that cellular heterogeneity in viral output exacerbates the rate of deleterious mutation accumulation, regardless of whether this heterogeneity in viral output is stochastic or is due to variation in the cellular multiplicity of infection. These results highlight the need to consider the unique life histories of viruses and their population structure to better understand observed patterns of viral evolution." @default.
• W4292608138 created "2022-08-22" @default.
• W4292608138 creator A5051861319 @default.
• W4292608138 creator A5054619927 @default.
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• W4292608138 date "2022-08-22" @default.
• W4292608138 modified "2023-09-27" @default.
• W4292608138 title "Heterogeneity in viral populations increases the rate of deleterious mutation accumulation" @default.
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• W4292608138 doi "https://doi.org/10.1093/genetics/iyac127" @default.
• W4292608138 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35993909" @default.
• W4292608138 hasPublicationYear "2022" @default.
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