Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292623930> ?p ?o ?g. }
- W4292623930 abstract "The phenol oxidase system is ancient and ubiquitously distributed in all living organisms. In various groups it serves for the biosynthesis of pigments and neurotransmitters (dopamine), defence reactions and tissue hardening. Ascidians belong to subphylum Tunicata, which is considered the closest living relative to Vertebrates. Two phenol oxidases previously described for ascidians are vertebrate-like and arthropod-like phenol oxidases. In our present study, we described a new ascidian protein, Tuphoxin, with putative phenol oxidase function, which bears no sequence similarity with two enzymes described previously. The closest related proteins to Tuphoxin are mollusc haemocyanins. Unlike haemocyanins, which are oxygen transporting plasma proteins, Tuphoxin is synthesised in ascidian blood cells and secreted in the extracellular matrix of the tunic-ascidian outer coverings. Single mature transcript coding for this phenol oxidase can give several protein products of different sizes. Thus limited proteolysis of the initial protein is suggested. A unique feature of Tuphoxins and their homologues among Tunicata is the presence of thrombospondin first type repeats (TSP1) domain in their sequence which is supposed to provide interaction with extracellular matrix. The finding of TSP1 in the structure of phenol oxidases is new and we consider this to be an innovation of Tunicata evolutionary lineage." @default.
- W4292623930 created "2022-08-22" @default.
- W4292623930 creator A5001033601 @default.
- W4292623930 creator A5007449483 @default.
- W4292623930 creator A5009531550 @default.
- W4292623930 creator A5013612473 @default.
- W4292623930 creator A5025427927 @default.
- W4292623930 creator A5030380744 @default.
- W4292623930 creator A5036540319 @default.
- W4292623930 creator A5041067110 @default.
- W4292623930 creator A5042164154 @default.
- W4292623930 creator A5062717456 @default.
- W4292623930 date "2022-08-22" @default.
- W4292623930 modified "2023-09-30" @default.
- W4292623930 title "New putative phenol oxidase in ascidian blood cells" @default.
- W4292623930 cites W109755099 @default.
- W4292623930 cites W129313138 @default.
- W4292623930 cites W1488957061 @default.
- W4292623930 cites W1509814577 @default.
- W4292623930 cites W1543209415 @default.
- W4292623930 cites W16992876 @default.
- W4292623930 cites W1843241824 @default.
- W4292623930 cites W1869937368 @default.
- W4292623930 cites W1896695878 @default.
- W4292623930 cites W1900418691 @default.
- W4292623930 cites W1919247897 @default.
- W4292623930 cites W1963515661 @default.
- W4292623930 cites W1963924039 @default.
- W4292623930 cites W1964693757 @default.
- W4292623930 cites W1969157447 @default.
- W4292623930 cites W1970068721 @default.
- W4292623930 cites W1974781567 @default.
- W4292623930 cites W1977831536 @default.
- W4292623930 cites W1978852670 @default.
- W4292623930 cites W1989590504 @default.
- W4292623930 cites W1990874860 @default.
- W4292623930 cites W1991807082 @default.
- W4292623930 cites W1992643802 @default.
- W4292623930 cites W1998159224 @default.
- W4292623930 cites W1999054494 @default.
- W4292623930 cites W1999810095 @default.
- W4292623930 cites W2003587139 @default.
- W4292623930 cites W2004589024 @default.
- W4292623930 cites W2004798786 @default.
- W4292623930 cites W2011657487 @default.
- W4292623930 cites W2015885001 @default.
- W4292623930 cites W2016951742 @default.
- W4292623930 cites W2020629753 @default.
- W4292623930 cites W2020716533 @default.
- W4292623930 cites W2026594509 @default.
- W4292623930 cites W2028291957 @default.
- W4292623930 cites W2028356706 @default.
- W4292623930 cites W2033191750 @default.
- W4292623930 cites W2036859794 @default.
- W4292623930 cites W2037159956 @default.
- W4292623930 cites W2041056624 @default.
- W4292623930 cites W2044658439 @default.
- W4292623930 cites W2045202298 @default.
- W4292623930 cites W2046878296 @default.
- W4292623930 cites W2057339191 @default.
- W4292623930 cites W2060022123 @default.
- W4292623930 cites W2061646488 @default.
- W4292623930 cites W2062065058 @default.
- W4292623930 cites W2065639980 @default.
- W4292623930 cites W2067243040 @default.
- W4292623930 cites W2069104726 @default.
- W4292623930 cites W2074349002 @default.
- W4292623930 cites W2077806048 @default.
- W4292623930 cites W2086352779 @default.
- W4292623930 cites W2087042268 @default.
- W4292623930 cites W2092046156 @default.
- W4292623930 cites W2093322868 @default.
- W4292623930 cites W2093922208 @default.
- W4292623930 cites W2094620274 @default.
- W4292623930 cites W2097382368 @default.
- W4292623930 cites W2104187422 @default.
- W4292623930 cites W2108590080 @default.
- W4292623930 cites W2113191844 @default.
- W4292623930 cites W2125620659 @default.
- W4292623930 cites W2127157137 @default.
- W4292623930 cites W2127774996 @default.
- W4292623930 cites W2129536004 @default.
- W4292623930 cites W2132228365 @default.
- W4292623930 cites W2132934971 @default.
- W4292623930 cites W2146192112 @default.
- W4292623930 cites W2146385204 @default.
- W4292623930 cites W2152230603 @default.
- W4292623930 cites W2157550346 @default.
- W4292623930 cites W2158714788 @default.
- W4292623930 cites W2161429638 @default.
- W4292623930 cites W2163627198 @default.
- W4292623930 cites W2171081570 @default.
- W4292623930 cites W2336400828 @default.
- W4292623930 cites W2349289192 @default.
- W4292623930 cites W2588875570 @default.
- W4292623930 cites W2605094667 @default.
- W4292623930 cites W2623935699 @default.
- W4292623930 cites W2749136745 @default.
- W4292623930 cites W2769508876 @default.
- W4292623930 cites W2770344858 @default.