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- W4292657417 abstract "Abstract Alcohol use disorder (AUD) is a chronic and fatal disease. The main impediment of the AUD therapy is a high probability of relapse to alcohol abuse even after prolonged abstinence. The molecular mechanisms of cue-induced relapse are not well established, despite the fact that they may offer new targets for the treatment of AUD. Using a comprehensive animal model of AUD, virally-mediated and amygdala-targeted genetic manipulations by CRISPR/Cas9 technology and ex vivo electrophysiology, we identify a mechanism that selectively controls cue-induced alcohol relapse and AUD symptom severity. This mechanism is based on activity-regulated cytoskeleton-associated protein (Arc)/ARG3.1-dependent plasticity of the amygdala synapses. In humans, we identified single nucleotide polymorphisms in the ARC gene and their methylation predicting not only amygdala size, but also frequency of alcohol use, even at the onset of regular consumption. Targeting Arc during alcohol cue exposure may thus be a selective new mechanism for relapse prevention." @default.
- W4292657417 created "2022-08-22" @default.
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- W4292657417 date "2022-08-22" @default.
- W4292657417 modified "2023-10-17" @default.
- W4292657417 title "Arc controls alcohol cue relapse by a central amygdala mechanism" @default.
- W4292657417 cites W1507966780 @default.
- W4292657417 cites W1601463464 @default.
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- W4292657417 cites W1966208053 @default.
- W4292657417 cites W1978686840 @default.
- W4292657417 cites W1995549311 @default.
- W4292657417 cites W1998019661 @default.
- W4292657417 cites W2005354224 @default.
- W4292657417 cites W2013185658 @default.
- W4292657417 cites W2032752029 @default.
- W4292657417 cites W2036996043 @default.
- W4292657417 cites W2038471213 @default.
- W4292657417 cites W2045165595 @default.
- W4292657417 cites W2051692581 @default.
- W4292657417 cites W2064815984 @default.
- W4292657417 cites W2079090326 @default.
- W4292657417 cites W2084376094 @default.
- W4292657417 cites W2089262034 @default.
- W4292657417 cites W2095732550 @default.
- W4292657417 cites W2098536790 @default.
- W4292657417 cites W2100705061 @default.
- W4292657417 cites W2102973376 @default.
- W4292657417 cites W2107277218 @default.
- W4292657417 cites W2112323466 @default.
- W4292657417 cites W2114059961 @default.
- W4292657417 cites W2114559471 @default.
- W4292657417 cites W2118224832 @default.
- W4292657417 cites W2133559478 @default.
- W4292657417 cites W2152059360 @default.
- W4292657417 cites W2157400934 @default.
- W4292657417 cites W2168307108 @default.
- W4292657417 cites W2185868183 @default.
- W4292657417 cites W2248682259 @default.
- W4292657417 cites W2479791564 @default.
- W4292657417 cites W2517001916 @default.
- W4292657417 cites W2555330260 @default.
- W4292657417 cites W2558817386 @default.
- W4292657417 cites W2567963378 @default.
- W4292657417 cites W2576762795 @default.
- W4292657417 cites W2602799162 @default.
- W4292657417 cites W2607270593 @default.
- W4292657417 cites W2620639795 @default.
- W4292657417 cites W2740177085 @default.
- W4292657417 cites W2752963108 @default.
- W4292657417 cites W2779115478 @default.
- W4292657417 cites W2790323041 @default.
- W4292657417 cites W2805844509 @default.
- W4292657417 cites W2807737217 @default.
- W4292657417 cites W2896040605 @default.
- W4292657417 cites W2910936809 @default.
- W4292657417 cites W2911508257 @default.
- W4292657417 cites W2913279861 @default.
- W4292657417 cites W2943929497 @default.
- W4292657417 cites W2970130866 @default.
- W4292657417 cites W2983698758 @default.
- W4292657417 cites W3012679632 @default.
- W4292657417 cites W3032421086 @default.
- W4292657417 cites W3035851377 @default.
- W4292657417 cites W3117515580 @default.
- W4292657417 cites W3135068371 @default.
- W4292657417 cites W4247665917 @default.
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- W4292657417 doi "https://doi.org/10.21203/rs.3.rs-1917417/v1" @default.
- W4292657417 hasPublicationYear "2022" @default.