Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292674805> ?p ?o ?g. }
- W4292674805 abstract "Despite therapeutic improvements in recent years, breast cancer remains an often fatal disease. In addition, breast cancer ulceration may occur during late stages, further complicating therapeutic or palliative interventions. In the past decade, a novel technology received significant attention in the medical field: gas plasma. This topical treatment relies on the partial ionization of gases that simultaneously produce a plethora of reactive oxygen and nitrogen species (ROS/RNS). Such local ROS/RNS overload inactivates tumour cells in a non-necrotic manner and was recently identified to induce immunogenic cancer cell death (ICD). ICD promotes dendritic cell maturation and amplifies antitumour immunity capable of targeting breast cancer metastases. Gas plasma technology was also shown to provide additive toxicity in combination with radio and chemotherapy and re-sensitized drug-resistant breast cancer cells. This work outlines the assets of gas plasma technology as a novel tool for targeting breast cancer by summarizing the action of plasma devices, the roles of ROS, signalling pathways, modes of cell death, combination therapies and immunological consequences of gas plasma exposure in breast cancer cells in vitro, in vivo, and in patient-derived microtissues ex vivo." @default.
- W4292674805 created "2022-08-23" @default.
- W4292674805 creator A5011618716 @default.
- W4292674805 creator A5053623492 @default.
- W4292674805 creator A5078105548 @default.
- W4292674805 date "2022-08-01" @default.
- W4292674805 modified "2023-10-01" @default.
- W4292674805 title "The potential of gas plasma technology for targeting breast cancer" @default.
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