Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292679884> ?p ?o ?g. }
- W4292679884 abstract "Diabetic nephropathy is a common complication of type I and type II diabetes, in which renal glomeruli are destroyed, resulting in renal damage, proteinuria, and hypertension. Apoptosis, autophagy, and necroptosis are 3 forms of programmed cell death that have been implicated in the pathogenesis of diabetic nephropathy. Apoptosis of podocytes leads to glomerular injury and podocyte depletion, which are associated with proteinuria and glomerular structural damage in diabetic nephropathy. Additionally, epithelial cells in the proximal convoluted tubules also undergo apoptosis in diabetic nephropathy, leading to tubular atrophy, which causes tubular cell depletion and the subsequent formation of atubular glomeruli in association with the loss of renal function. On the other hand, insufficiency of autophagy has been correlated with the pathogenesis of diabetic nephropathy. For instance, decreased autophagic activity has been shown in podocytes of the diabetic kidney, causing variations in podocyte function and subsequent disruption to the glomerular filtration barrier. Furthermore, attenuated autophagic activity has also been demonstrated in proximal tubular cells of the diabetic kidney, resulting in the buildup of impaired molecules and organelles, which are normally broken down by autophagy, leading to proteinuria. Moreover, necroptosis might have a key role in podocyte damage and subsequent decline in diabetic nephropathy. Thus, this article aims to review the mechanisms and effects of programmed cell death in diabetic nephropathy, including the roles of apoptosis, autophagy, and necroptosis." @default.
- W4292679884 created "2022-08-23" @default.
- W4292679884 creator A5056967355 @default.
- W4292679884 date "2022-08-10" @default.
- W4292679884 modified "2023-10-13" @default.
- W4292679884 title "Programmed Cell Death in Diabetic Nephropathy: A Review of Apoptosis, Autophagy, and Necroptosis" @default.
- W4292679884 cites W2011670301 @default.
- W4292679884 cites W2025914300 @default.
- W4292679884 cites W2029607958 @default.
- W4292679884 cites W2049857974 @default.
- W4292679884 cites W2096478902 @default.
- W4292679884 cites W2100260879 @default.
- W4292679884 cites W2104785025 @default.
- W4292679884 cites W2110645858 @default.
- W4292679884 cites W2111352765 @default.
- W4292679884 cites W2114889530 @default.
- W4292679884 cites W2124213076 @default.
- W4292679884 cites W2126207811 @default.
- W4292679884 cites W2132652380 @default.
- W4292679884 cites W2136361664 @default.
- W4292679884 cites W2140761309 @default.
- W4292679884 cites W2149152787 @default.
- W4292679884 cites W2191038342 @default.
- W4292679884 cites W2193925300 @default.
- W4292679884 cites W2195210582 @default.
- W4292679884 cites W2255104527 @default.
- W4292679884 cites W2257214644 @default.
- W4292679884 cites W2284443530 @default.
- W4292679884 cites W2296097249 @default.
- W4292679884 cites W2337636620 @default.
- W4292679884 cites W2346288848 @default.
- W4292679884 cites W2409344485 @default.
- W4292679884 cites W2434638516 @default.
- W4292679884 cites W2460126198 @default.
- W4292679884 cites W2479269302 @default.
- W4292679884 cites W2549375482 @default.
- W4292679884 cites W2561520623 @default.
- W4292679884 cites W2564407987 @default.
- W4292679884 cites W2583476095 @default.
- W4292679884 cites W2588205705 @default.
- W4292679884 cites W2588959632 @default.
- W4292679884 cites W2589426237 @default.
- W4292679884 cites W2592941914 @default.
- W4292679884 cites W2594748846 @default.
- W4292679884 cites W2602060453 @default.
- W4292679884 cites W2605479507 @default.
- W4292679884 cites W2610328326 @default.
- W4292679884 cites W2610514067 @default.
- W4292679884 cites W2615714795 @default.
- W4292679884 cites W2624312794 @default.
- W4292679884 cites W2625887862 @default.
- W4292679884 cites W2725911293 @default.
- W4292679884 cites W2738598016 @default.
- W4292679884 cites W2740451759 @default.
- W4292679884 cites W2751019535 @default.
- W4292679884 cites W2752265698 @default.
- W4292679884 cites W2757565199 @default.
- W4292679884 cites W2762167080 @default.
- W4292679884 cites W2763871199 @default.
- W4292679884 cites W2766223190 @default.
- W4292679884 cites W2767924566 @default.
- W4292679884 cites W2768768130 @default.
- W4292679884 cites W2769632036 @default.
- W4292679884 cites W2770483809 @default.
- W4292679884 cites W2771826181 @default.
- W4292679884 cites W2775286112 @default.
- W4292679884 cites W2778979662 @default.
- W4292679884 cites W2781136666 @default.
- W4292679884 cites W2789348215 @default.
- W4292679884 cites W2789348909 @default.
- W4292679884 cites W2791895358 @default.
- W4292679884 cites W2791990516 @default.
- W4292679884 cites W2803563276 @default.
- W4292679884 cites W2851271116 @default.
- W4292679884 cites W2883611070 @default.
- W4292679884 cites W2886442927 @default.
- W4292679884 cites W2887837540 @default.
- W4292679884 cites W2888326900 @default.
- W4292679884 cites W2888584880 @default.
- W4292679884 cites W2890298129 @default.
- W4292679884 cites W2890347012 @default.
- W4292679884 cites W2891866165 @default.
- W4292679884 cites W2892820035 @default.
- W4292679884 cites W2892870547 @default.
- W4292679884 cites W2897151822 @default.
- W4292679884 cites W2897321615 @default.
- W4292679884 cites W2897782627 @default.
- W4292679884 cites W2900379762 @default.
- W4292679884 cites W2901164800 @default.
- W4292679884 cites W2902493914 @default.
- W4292679884 cites W2903828449 @default.
- W4292679884 cites W2908974630 @default.
- W4292679884 cites W2927935720 @default.
- W4292679884 cites W2929633637 @default.
- W4292679884 cites W2938394881 @default.
- W4292679884 cites W2939056166 @default.
- W4292679884 cites W2942886351 @default.
- W4292679884 cites W2952510256 @default.
- W4292679884 cites W2954850953 @default.
- W4292679884 cites W2956714488 @default.