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- W4292680041 startingPage "1291" @default.
- W4292680041 abstract "Wnt signaling executes an indispensable performance in osteoblast differentiation, bone development, homeostasis, and remodeling. Wnt signals trigger the intracellular Wnt signaling cascade to initiate regulating the implication of β-catenin in the bone environment. Going through the novel discoveries done via high-throughput sequencing technologies on genetic mouse models, we highlighted the significant contribution of Wnt ligands, co-receptors, inhibitors, their related skeletal phenotypes in mouse models and the similar bone disorders clinically observed in human beings. Moreover, the crosstalk between Wnt signaling pathway and BMP, TGF-β, FGF, Hippo, Hedgehog, Notch and PDGF signaling pathways is thoroughly demonstrated to be the underlying gene regulatory network that orchestrates osteoblast differentiation and bone development. We also introspected the significance of Wnt signaling transduction in the reorganization of cellular metabolism by stimulating glycolysis, glutamine catabolism, and fatty acid oxidation in osteoblast-lineage cells that display an important regulatory arbor in the cellular bioenergetics of the bone. Throughout this evaluation, most to date therapeutical approaches towards osteoporosis and other bone maladies found in human beings, are formulated with an aspiration to holistically revamp the present clinical applications involving various monoclonal antibodies therapies that lack specificity, efficacy, and safety into more requisite advanced therapeutics that satisfy these three requirements for further clinical considerations. Conclusively, our review provides comprehensive scientific findings related to the fundamental significance of Wnt signaling cascades in skeletal system and the underlying gene regulatory network with other signaling pathways enlightening researchers with the possibility to further integrate the identified target molecules into therapeutic strategies for skeletal disorders treatment in the clinic." @default.
- W4292680041 created "2022-08-23" @default.
- W4292680041 creator A5013051603 @default.
- W4292680041 creator A5043370802 @default.
- W4292680041 creator A5050905041 @default.
- W4292680041 creator A5056415211 @default.
- W4292680041 date "2023-07-01" @default.
- W4292680041 modified "2023-10-16" @default.
- W4292680041 title "Wnt signaling: Essential roles in osteoblast differentiation, bone metabolism and therapeutic implications for bone and skeletal disorders" @default.
- W4292680041 cites W1485743594 @default.
- W4292680041 cites W1516032812 @default.
- W4292680041 cites W1550905080 @default.
- W4292680041 cites W1557541313 @default.
- W4292680041 cites W1589352523 @default.
- W4292680041 cites W1594526962 @default.
- W4292680041 cites W1611720630 @default.
- W4292680041 cites W1900557155 @default.
- W4292680041 cites W1901220202 @default.
- W4292680041 cites W1907029095 @default.
- W4292680041 cites W1909817432 @default.
- W4292680041 cites W1963481639 @default.
- W4292680041 cites W1963686806 @default.
- W4292680041 cites W1966414415 @default.
- W4292680041 cites W1967053032 @default.
- W4292680041 cites W1967073403 @default.
- W4292680041 cites W1967598128 @default.
- W4292680041 cites W1967819106 @default.
- W4292680041 cites W1968623757 @default.
- W4292680041 cites W1969279069 @default.
- W4292680041 cites W1969758161 @default.
- W4292680041 cites W1971829846 @default.
- W4292680041 cites W1974506260 @default.
- W4292680041 cites W1976206175 @default.
- W4292680041 cites W1976329877 @default.
- W4292680041 cites W1978421713 @default.
- W4292680041 cites W1979471273 @default.
- W4292680041 cites W1980464649 @default.
- W4292680041 cites W1980666946 @default.
- W4292680041 cites W1980794764 @default.
- W4292680041 cites W1981020155 @default.
- W4292680041 cites W1985012226 @default.
- W4292680041 cites W1989306241 @default.
- W4292680041 cites W1989918771 @default.
- W4292680041 cites W1990462911 @default.
- W4292680041 cites W1991162692 @default.
- W4292680041 cites W1992027368 @default.
- W4292680041 cites W1994029539 @default.
- W4292680041 cites W1994325388 @default.
- W4292680041 cites W1995401177 @default.
- W4292680041 cites W1996570637 @default.
- W4292680041 cites W1998511060 @default.
- W4292680041 cites W1998758244 @default.
- W4292680041 cites W1999418860 @default.
- W4292680041 cites W2000575177 @default.
- W4292680041 cites W2002725330 @default.
- W4292680041 cites W2004027999 @default.
- W4292680041 cites W2004042093 @default.
- W4292680041 cites W2004558834 @default.
- W4292680041 cites W2004818856 @default.
- W4292680041 cites W2005644023 @default.
- W4292680041 cites W2005726256 @default.
- W4292680041 cites W2006419043 @default.
- W4292680041 cites W2007916618 @default.
- W4292680041 cites W2008432341 @default.
- W4292680041 cites W2009684443 @default.
- W4292680041 cites W2010496313 @default.
- W4292680041 cites W2011520135 @default.
- W4292680041 cites W2011991737 @default.
- W4292680041 cites W2012884263 @default.
- W4292680041 cites W2014684686 @default.
- W4292680041 cites W2015050458 @default.
- W4292680041 cites W2017965242 @default.
- W4292680041 cites W2019582558 @default.
- W4292680041 cites W2020469763 @default.
- W4292680041 cites W2020543900 @default.
- W4292680041 cites W2021470881 @default.
- W4292680041 cites W2023016113 @default.
- W4292680041 cites W2023985722 @default.
- W4292680041 cites W2024499742 @default.
- W4292680041 cites W2025827978 @default.
- W4292680041 cites W2026257628 @default.
- W4292680041 cites W2029456301 @default.
- W4292680041 cites W2029674033 @default.
- W4292680041 cites W2030168966 @default.
- W4292680041 cites W2031883266 @default.
- W4292680041 cites W2032379561 @default.
- W4292680041 cites W2033276135 @default.
- W4292680041 cites W2034826045 @default.
- W4292680041 cites W2034887444 @default.
- W4292680041 cites W2035809306 @default.
- W4292680041 cites W2036421755 @default.
- W4292680041 cites W2036588462 @default.
- W4292680041 cites W2036615406 @default.
- W4292680041 cites W2037978897 @default.
- W4292680041 cites W2038134714 @default.
- W4292680041 cites W2040400629 @default.
- W4292680041 cites W2041141449 @default.
- W4292680041 cites W2044413297 @default.