FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292681852> ?p ?o ?g. }

• W4292681852 endingPage "513" @default.
• W4292681852 startingPage "497" @default.
• W4292681852 abstract "Hyperfibrinolysis and coagulation dysfunction may occur in cirrhotic patients with acute variceal bleed (AVB) despite successful endotherapy. To prospectively study the association of endogenous heparinoids and coagulation dysfunction with variceal rebleeding and outcome in cirrhosis. Consecutive patients were assessed with conventional coagulation tests, SONOCLOT™ [(global(gb) and heparinase(h) treated] and factors VII, VIII, XIII, X, tissue plasminogen activator, and plasminogen activator inhibitor ELISA assays in a university hospital. Heparin-like-effect (HLE) was defined as ≥ 20% difference in paired gb/h-SONOCLOT™ traces for activated clotting time (ACT). Of 143 patients screened, 90 (46.4 ± 11.7 years, males 82.2%, ethanol-related 58.8%) were recruited, who bled from esophageal varices (81,90.0%), gastric varices (6,6.6%), or esophageal varices with portal hypertensive gastropathy (3,3.3%). Twenty (21.7%) had early rebleeding, mainly post-variceal ligation ulcer related (70%). Patients who rebled had low Factor XIII [1.6 (1.2–2.1) vs 2.4 ng/ml (2.0–2.8) P = 0.035] and Factor VII (94.1 ± 46.9 vs. 124.0 ± 50.4, P = 0.023). On receiver operating curve analysis, the gbACT > 252 s (sensitivity 86.8%, specificity 76.9%, P < 0.001), hACT > 215 s (sensitivity 71.1%, specificity 70.3%, P < 0.001), and HLE > 50% (sensitivity 69.5%, specificity 70.3%, P = 0.006) predicted rebleeding. Baseline Factor VIII (HR 1.26; 95% CI 1.17–1.34, P < 0.001), low factor VII (HR 0.89; 95% CI 0.76–0.98, P = 0.035), and lysis (HR 1.25, 95% CI 1.17–1.33, P < 0.001) predicted mortality. Endogenous heparinoids at baseline predicted sepsis (HR 1.8; 95% CI 1.4–6.5; P = 0.022), rebleeding events (HR 1.2; 95% CI 1.1–6.3; P = 0.030), and mortality (HR 1.1; 95% CI 1.0–4.6; P = 0.030). Hyperfibrinolysis, Factor VII/XIII deficiency, and HLE are associated with rebleeding after AVB. Trial Registration NCT04111120 available from https://clinicaltrials.gov/ct2/show/NCT04111120 ." @default.
• W4292681852 created "2022-08-23" @default.
• W4292681852 creator A5000464419 @default.
• W4292681852 creator A5001912728 @default.
• W4292681852 creator A5013493873 @default.
• W4292681852 creator A5032351621 @default.
• W4292681852 creator A5037076474 @default.
• W4292681852 creator A5038348038 @default.
• W4292681852 creator A5040682018 @default.
• W4292681852 creator A5044538545 @default.
• W4292681852 creator A5045640684 @default.
• W4292681852 creator A5052966640 @default.
• W4292681852 creator A5054713971 @default.
• W4292681852 creator A5055112118 @default.
• W4292681852 creator A5055368865 @default.
• W4292681852 creator A5062468782 @default.
• W4292681852 creator A5065833346 @default.
• W4292681852 creator A5071567530 @default.
• W4292681852 creator A5085969978 @default.
• W4292681852 date "2022-08-19" @default.
• W4292681852 modified "2023-09-27" @default.
• W4292681852 title "Association of Heparin-Like Effect, Factor VII/XIII Deficiency and Fibrinolysis with Rebleeding Risk in Cirrhosis with Acute Variceal Bleeding" @default.
• W4292681852 cites W1965482373 @default.
• W4292681852 cites W1993192315 @default.
• W4292681852 cites W2006963507 @default.
• W4292681852 cites W2019762012 @default.
• W4292681852 cites W2022985666 @default.
• W4292681852 cites W2032692913 @default.
• W4292681852 cites W2061028801 @default.
• W4292681852 cites W2081927623 @default.
• W4292681852 cites W2105369912 @default.
• W4292681852 cites W2124587282 @default.
• W4292681852 cites W2148373446 @default.
• W4292681852 cites W2167068882 @default.
• W4292681852 cites W2280404143 @default.
• W4292681852 cites W2519905028 @default.
• W4292681852 cites W2734609612 @default.
• W4292681852 cites W2739234165 @default.
• W4292681852 cites W2809833128 @default.
• W4292681852 cites W2907244794 @default.
• W4292681852 cites W2909805340 @default.
• W4292681852 cites W2943918698 @default.
• W4292681852 cites W2946946736 @default.
• W4292681852 cites W2989714602 @default.
• W4292681852 cites W3023252335 @default.
• W4292681852 cites W3040316445 @default.
• W4292681852 cites W3045469049 @default.
• W4292681852 cites W3096849632 @default.
• W4292681852 cites W3158664492 @default.
• W4292681852 cites W3160303902 @default.
• W4292681852 cites W3160778596 @default.
• W4292681852 cites W4200473175 @default.
• W4292681852 cites W4224216090 @default.
• W4292681852 cites W4225397868 @default.
• W4292681852 cites W4297907675 @default.
• W4292681852 doi "https://doi.org/10.1007/s10620-022-07656-9" @default.
• W4292681852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35984611" @default.
• W4292681852 hasPublicationYear "2022" @default.
• W4292681852 type Work @default.
• W4292681852 citedByCount "0" @default.
• W4292681852 crossrefType "journal-article" @default.
• W4292681852 hasAuthorship W4292681852A5000464419 @default.
• W4292681852 hasAuthorship W4292681852A5001912728 @default.
• W4292681852 hasAuthorship W4292681852A5013493873 @default.
• W4292681852 hasAuthorship W4292681852A5032351621 @default.
• W4292681852 hasAuthorship W4292681852A5037076474 @default.
• W4292681852 hasAuthorship W4292681852A5038348038 @default.
• W4292681852 hasAuthorship W4292681852A5040682018 @default.
• W4292681852 hasAuthorship W4292681852A5044538545 @default.
• W4292681852 hasAuthorship W4292681852A5045640684 @default.
• W4292681852 hasAuthorship W4292681852A5052966640 @default.
• W4292681852 hasAuthorship W4292681852A5054713971 @default.
• W4292681852 hasAuthorship W4292681852A5055112118 @default.
• W4292681852 hasAuthorship W4292681852A5055368865 @default.
• W4292681852 hasAuthorship W4292681852A5062468782 @default.
• W4292681852 hasAuthorship W4292681852A5065833346 @default.
• W4292681852 hasAuthorship W4292681852A5071567530 @default.
• W4292681852 hasAuthorship W4292681852A5085969978 @default.
• W4292681852 hasBestOaLocation W42926818521 @default.
• W4292681852 hasConcept C126322002 @default.
• W4292681852 hasConcept C141071460 @default.
• W4292681852 hasConcept C2776825266 @default.
• W4292681852 hasConcept C2777214474 @default.
• W4292681852 hasConcept C2777595160 @default.
• W4292681852 hasConcept C2778012290 @default.
• W4292681852 hasConcept C2778808290 @default.
• W4292681852 hasConcept C2779679481 @default.
• W4292681852 hasConcept C2781219028 @default.
• W4292681852 hasConcept C41260117 @default.
• W4292681852 hasConcept C71924100 @default.
• W4292681852 hasConcept C90924648 @default.
• W4292681852 hasConceptScore W4292681852C126322002 @default.
• W4292681852 hasConceptScore W4292681852C141071460 @default.
• W4292681852 hasConceptScore W4292681852C2776825266 @default.
• W4292681852 hasConceptScore W4292681852C2777214474 @default.
• W4292681852 hasConceptScore W4292681852C2777595160 @default.
• W4292681852 hasConceptScore W4292681852C2778012290 @default.
• W4292681852 hasConceptScore W4292681852C2778808290 @default.

• next