Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292685145> ?p ?o ?g. }
- W4292685145 endingPage "113386" @default.
- W4292685145 startingPage "113386" @default.
- W4292685145 abstract "Ochratoxin A (OTA), a mycotoxin produced by Aspergillus and Penicillium fungi, widely contaminates feed, food and their raw materials. OTA has been proved to have hepatotoxicity and nephrotoxicity. Its reproductive toxicity needs to be further explored. We found that OTA inhibited the progression of meiosis, keeping more germ cells at leptotene and zygotene. Furthermore, OTA impaired primordial follicle formation, keeping more germ cells in cysts. Increased γH2AX suggested that DNA damage occurred both at the stages of meiosis and primordial follicle formation. The expression of RAD51 increased with the concentration of OTA at the stage of meiosis, while decreased later, suggesting the activated DNA repair induced by DNA damage then inhibited by persistent and excessive stress of DNA damage, which further induced apoptosis. DEGs caused by OTA were also mainly enriched in DNA damage and repair through RNA-seq analysis. Higher level of reactive oxygen species (ROS) and increased degree of oxidative damage marker 8-OHdG were both found in the ovaries exposed to OTA. We concluded that maternal OTA exposure affected meiosis progression and primordial follicle formation via oxidative damage and DNA repair. Clarification of the mechanism of OTA will contribute to the development of more effective detoxification strategies." @default.
- W4292685145 created "2022-08-23" @default.
- W4292685145 creator A5002866463 @default.
- W4292685145 creator A5033083323 @default.
- W4292685145 creator A5034182089 @default.
- W4292685145 creator A5042848426 @default.
- W4292685145 creator A5065806417 @default.
- W4292685145 creator A5070600807 @default.
- W4292685145 creator A5076730307 @default.
- W4292685145 creator A5077092076 @default.
- W4292685145 date "2022-10-01" @default.
- W4292685145 modified "2023-10-17" @default.
- W4292685145 title "Maternal ochratoxin A exposure impairs meiosis progression and primordial follicle formation of F1 offspring" @default.
- W4292685145 cites W1639816383 @default.
- W4292685145 cites W1756131747 @default.
- W4292685145 cites W1780348968 @default.
- W4292685145 cites W1901966598 @default.
- W4292685145 cites W1995487652 @default.
- W4292685145 cites W2007018695 @default.
- W4292685145 cites W2027397981 @default.
- W4292685145 cites W2029943784 @default.
- W4292685145 cites W2039230747 @default.
- W4292685145 cites W2039867173 @default.
- W4292685145 cites W2046195303 @default.
- W4292685145 cites W2067338267 @default.
- W4292685145 cites W2068364416 @default.
- W4292685145 cites W2107516157 @default.
- W4292685145 cites W2111366014 @default.
- W4292685145 cites W2116581941 @default.
- W4292685145 cites W2122494067 @default.
- W4292685145 cites W2132407383 @default.
- W4292685145 cites W2134710117 @default.
- W4292685145 cites W2140159026 @default.
- W4292685145 cites W2145200068 @default.
- W4292685145 cites W2272916692 @default.
- W4292685145 cites W2588557803 @default.
- W4292685145 cites W2612428976 @default.
- W4292685145 cites W2612621945 @default.
- W4292685145 cites W2742640224 @default.
- W4292685145 cites W2781513035 @default.
- W4292685145 cites W2809370611 @default.
- W4292685145 cites W2809877110 @default.
- W4292685145 cites W2911110467 @default.
- W4292685145 cites W2972225545 @default.
- W4292685145 cites W2973011115 @default.
- W4292685145 cites W2980934775 @default.
- W4292685145 cites W2989367454 @default.
- W4292685145 cites W3003933314 @default.
- W4292685145 cites W3007447010 @default.
- W4292685145 cites W3011321628 @default.
- W4292685145 cites W3011819147 @default.
- W4292685145 cites W3011950827 @default.
- W4292685145 cites W3021021855 @default.
- W4292685145 cites W3027160328 @default.
- W4292685145 cites W3027605339 @default.
- W4292685145 cites W3049103159 @default.
- W4292685145 cites W3112750986 @default.
- W4292685145 cites W3118104863 @default.
- W4292685145 cites W3159150864 @default.
- W4292685145 cites W3207097826 @default.
- W4292685145 cites W3213398501 @default.
- W4292685145 cites W3214091155 @default.
- W4292685145 doi "https://doi.org/10.1016/j.fct.2022.113386" @default.
- W4292685145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36007852" @default.
- W4292685145 hasPublicationYear "2022" @default.
- W4292685145 type Work @default.
- W4292685145 citedByCount "0" @default.
- W4292685145 crossrefType "journal-article" @default.
- W4292685145 hasAuthorship W4292685145A5002866463 @default.
- W4292685145 hasAuthorship W4292685145A5033083323 @default.
- W4292685145 hasAuthorship W4292685145A5034182089 @default.
- W4292685145 hasAuthorship W4292685145A5042848426 @default.
- W4292685145 hasAuthorship W4292685145A5065806417 @default.
- W4292685145 hasAuthorship W4292685145A5070600807 @default.
- W4292685145 hasAuthorship W4292685145A5076730307 @default.
- W4292685145 hasAuthorship W4292685145A5077092076 @default.
- W4292685145 hasConcept C102570824 @default.
- W4292685145 hasConcept C104317684 @default.
- W4292685145 hasConcept C134018914 @default.
- W4292685145 hasConcept C134935766 @default.
- W4292685145 hasConcept C143425029 @default.
- W4292685145 hasConcept C148196450 @default.
- W4292685145 hasConcept C16685009 @default.
- W4292685145 hasConcept C196843134 @default.
- W4292685145 hasConcept C2776008721 @default.
- W4292685145 hasConcept C2776151105 @default.
- W4292685145 hasConcept C2778324911 @default.
- W4292685145 hasConcept C2779012473 @default.
- W4292685145 hasConcept C2780536345 @default.
- W4292685145 hasConcept C39297687 @default.
- W4292685145 hasConcept C48349386 @default.
- W4292685145 hasConcept C54355233 @default.
- W4292685145 hasConcept C5512455 @default.
- W4292685145 hasConcept C552990157 @default.
- W4292685145 hasConcept C59822182 @default.
- W4292685145 hasConcept C71924100 @default.
- W4292685145 hasConcept C84699730 @default.
- W4292685145 hasConcept C86803240 @default.