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- W4292685583 endingPage "146832" @default.
- W4292685583 startingPage "146832" @default.
- W4292685583 abstract "Polycomb and Trithorax group proteins (PcG, TrxG) epigenetically regulate developmental genes. These proteins bind with specific DNA elements, the Polycomb Response Element (PRE). Apart from mutations in polycomb/ trithorax proteins, altered cis-elements like PRE underlie the modified function and thus disease etiology. PREs are well studied in Drosophila, while only a few human PREs have been reported. We have identified a polycomb responsive DNA element, hPRE-HoxA3, in the intron of the HoxA3 gene. The hPRE-HoxA3 represses luciferase reporter activity in a PcG-dependent manner. The endogenous hPRE-HoxA3 element recruits PcG proteins and is enriched with repressive H3K27me3 marks, demonstrating that hPRE-HoxA3 is a part of the PcG-dependent gene regulatory network. Furthermore, it interacts with D11-12, the well-known PRE in the human Hox cluster. hPRE-Hox3 is a part of the 3-dimensional chromosomal domain organization as it is involved in the long-range interaction with other PcG enriched regions of Hox A, B, C, and D clusters." @default.
- W4292685583 created "2022-08-23" @default.
- W4292685583 creator A5007761510 @default.
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- W4292685583 date "2022-12-01" @default.
- W4292685583 modified "2023-10-16" @default.
- W4292685583 title "Identification of a polycomb responsive region in human HoxA cluster and its long-range interaction with polycomb enriched genomic regions" @default.
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- W4292685583 doi "https://doi.org/10.1016/j.gene.2022.146832" @default.
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