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• W4292693526 abstract "Abstract Background Canine heartworm is a widespread and potentially fatal mosquito-borne disease caused by infections with the parasitic nematode, Dirofilaria immitis . We have previously shown that systemic activation of the Toll immune pathway via silencing of the negative regulator Cactus in Aedes aegypti blocks parasite development in the Malpighian tubules, the mosquito renal organ. However, it was not established whether the Malpighian tubules were directly responding to Toll activation or were alternatively responding to upregulated proteins or other changes to the hemolymph driven by other tissues. Distinguishing these possibilities is crucial for developing more precise strategies to block D. immitis while potentially avoiding the fitness cost to the mosquito associated with Cactus silencing. Methods This study defines the transcriptional response Malpighian tubules and changes to the hemolymph proteome of Ae. aegypti after systemic Toll activation via intra-thoracic injection of ds Cactus . Results We found Malpighian tubules significantly increase expression of Toll pathway target genes that significantly overlapped expression changes occurring in whole mosquitoes. Additionally, we identified a significant overlap between the transcriptional response of the Malpighian tubules and proteins upregulated in the hemolymph. Conclusions Our data show that Malpighian tubules are capable of RNAi-mediated gene silencing and directly respond to ds Cactus treatment by upregulating canonical Toll pathway targets. Though not definitive, the strong correspondence between the Malpighian tubule transcriptional and the hemolymph proteomic responses provides evidence that the tubules may contribute to mosquito humoral immunity." @default.
• W4292693526 created "2022-08-23" @default.
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• W4292693526 date "2022-08-22" @default.
• W4292693526 modified "2023-09-28" @default.
• W4292693526 title "<i>Aedes aegypti</i> Malpighian tubules are immunologically activated following systemic Toll activation" @default.
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• W4292693526 doi "https://doi.org/10.1101/2022.08.21.504691" @default.
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